[Experimental study of the action of Bunium persicum oil on the functional state of the liver and pancreas]. / Eksperimental'noe izuchenie deistviia masla Bunium persicum na funktsional'noe sostoianie pecheni i podzheludochnoi zhelezy.

The effect of Bunium Persicum oil on the indices of lipid-lipoid and protein-nitrogen metabolism and of the enzymes (histidase, arginase, transamidinase, trypsin and trypsin inhibitor) reflecting the function of the liver and pancreas was studied in experiments on white rats. There was an improvement of the indices of protein nitrogen metabolism in administration of the oil alone and combined with ethanol and CCl4. At the same time the content of total lipids and cholesterol in the blood serum and in the liver increased. The activity of the enzymes of the blood serum, liver homogenates and the pancreas reflected organ specificity and changed simultaneously with alterations in the general trend of the metabolism.

[Oleum hippophaë, a stabilizer of biological membranes]. / Oblepikhovoe maslo--stabilizator biologicheskikh membran.

Toxic lesion of the liver was reproduced in albino rats by way of a separate and combined intragastric administration of a 20 per cent ethanol (in doses of 0.65 ml/100 g of mass) and of a 20 per cent CCl4 oil solution (in amounts of 0.3 ml/100 g of mass), thrice in a week for 3 months. Subject to investigation were the intensity of the lipids peroxidation with reference to the diene conjugates level in the liver tissue and peroxide resistance of the peripheral blood erythrocytes, P-450 cytochromes in the supernatant fluid after precipitation of the nuclei and mitochondria, total liver protein and subcellular structures, water-soluble liver protein. The activity of the P-450 cytochrome and the content of the total and water-soluble liver protein were found to change antibathmically to the lipids oxidation intensity, especially in animals receiving both poisons. Oleum hippopheae causes a well-marked anabolic effect which manifests itself in an increased proportion of tissular and serumal proteins. It lowers the free radical oxidation of the lipids, protects the cytochromes P-450 against damage. The mechanisms of the results, obtained are discussed.