Investigation of synthesized ethyl-(2-(5-arylidine-2,4-dioxothiazolidin-3-yl) acetyl) butanoate as an effective corrosion inhibitor for mild steel in 1 M HCl: A gravimetric, electrochemical, and spectroscopic study.

The corrosion inhibition effects of five concentrations (5E-5 M to 9E-5 M) of ethyl-(2-(5-arylidine-2,4-dioxothiazolidin-3-yl) acetyl) butanoate, a novel thiazolidinedione derivative code named B1, were investigated on mild steel in 1 M HCl using gravimetric analysis, electrochemical analysis and Fourier transform infrared spectroscopy. After synthesis and purification, B1 was characterized using nuclear magnetic resonance spectroscopy. All gravimetric analysis experiments were carried out at four different temperatures: 303.15 K, 313.15 K, 323.15 K and 333.15 K, achieving a maximum percentage inhibition efficiency of 92% at 303.15 K. The maximum percentage inhibition efficiency obtained from electrochemical analysis, conducted at 303.15 K, was 83%. Thermodynamic parameters such as ΔG°ads showed that B1 adsorbs onto the MS surface via a mixed type of action at lower temperatures, transitioning to exclusively chemisorption at higher temperatures.

Exploration of synthesized quaternary ammonium ionic liquids as unharmful anti-corrosives for aluminium utilizing hydrochloric acid medium.

1-(benzyloxy)-1-oxopropan-2-aminium 4-methylbenzenesulfonate (BOPAMS) and 4-(benzyloxy)-4-oxobutan-1-aminium 4-methylbenzenesulfonate (BOBAMS) were prepared and confirmed through spectroscopic methods (FT-Infrared, Carbon 13-NMR and Proton-NMR). BOPAMS and BOBAMS were evaluated as unharmful inhibitors for aluminium corrosion. The anti-corrosive properties, inhibition mechanism, inhibitor-metal adsorption behaviour and corrosion inhibition efficiency were evaluated by employing approaches like gravimetric, potentiodynamic polarization (PDP) and electrochemical impedance spectroscopy (EIS). FT-IR demonstrated functional groups that are responsible for the binding of BOPAMS and BOBAMS with surfaces of aluminium. BOPAMS and BOBAMS resemble a semi-chemisorption/physisorption mechanism, obeying Langmuir binding model. The mechanism of binding adopted by BOPAMS and BOBAMS was proposed.

Imidazo[1,2-a]pyridin-3-amines as potential HIV-1 non-nucleoside reverse transcriptase inhibitors.

During random screening of a small in-house library of compounds, certain substituted imidazo[1,2-a]pyridines were found to be weak allosteric inhibitors of HIV-1 reverse transcriptase (RT). A library of these compounds was prepared using the Groebke reaction and a subset of compounds prepared from 2-chlorobenzaldehyde, cyclohexyl isocyanide and a 6-substituted 2-aminopyridine showed good inhibitory activity in enzymatic (RT) and HIV anti-infectivity MAGI whole cell assays. The compound showing the best anti-HIV-1 IIIB whole cell activity (MAGI IC(50)=0.18 µM, IC(90)=1.06 µM), along with a good selectivity index (>800), was 2-(2-chlorophenyl)-3-(cyclohexylamino)imidazo[1,2-a]pyridine-5-carbonitrile 38.

Expeditious synthesis and biological evaluation of novel 2,N6-disubstituted 1,2-dihydro-1,3,5-triazine-4,6-diamines as potential antimalarials.

A small set of novel 2,N6-disubstituted 1,2-dihydro-1,3,5-triazine-4,6-diamines was prepared possessing a flexible tether between the exocyclic nitrogen bonded to C-6 of the 1,2-dihydro-1,3,5-triazine-4,6-diamine heterocycle and the distal aryl ring. Three zones were varied in this series of compounds, namely the nature of the substituent(s) on C-2; the nature of the substituent(s) on the distal aryl ring; as well as the nature and length of the flexible tether between the rings. The compound showing the best antimalarial activity (cycloguanil-resistant FCR-3 Plasmodium falciparum IC50=0.99 µM) was N6-(3-(4-chlorophenoxy)propyl)-2-(furan-2-yl)-1,2-dihydro-1,3,5-triazine-4,6-diamine hydrochloride.