[The effect of ethanol on the bile-secreting function of the liver in rats]. / Vliianie étanola na zhelcheotdelitel'nuiu funktsiiu pecheni u krys.

The effect of long-term application of ethanol on the biochemical composition of rat bile has been studied. These results have been compared with the changes of activity of hepatic microsomal enzymes and ultrastructure of hepatocytes. The changes of biliary lipid synthesis and secretion have been shown to reflect the change of microsomal metabolic functions and to be accompanied by liver destruction processes.

[Ultrastructural detection of cholesterol in the liver of rats with alcoholic intoxication]. / Ul'trastrukturnoe vyiavlenie kholesterina v pecheni pri alkogol'noi intoksikatsii u krys.

The deposits of cholesterol in hepatocytes in alcoholic rats were studied by means of cytochemical method. It was shown the localization of cholesterol in intracellular as well as extracellular compartment. In numerous hepatocytes there was observed a destruction of mitochondria, rough endoplasmic reticulum and plasma membranes. It was observed two structural forms of digitonin cholesterol complexes: structures like "crinkles" and small cylinders and multilamellar ones.

[Physiological functions of bile acids in the body]. / Fiziologicheskie funktsii zhelchnykh kislot v organizme.

A literary review and own data on the various physiological functions of bile acids in organism are given. The modern state of the problem on the bile salt role in lipid assimilation is reflected. The other functions of bile salts in the digestive tract are described. The regulating influence of bile acids on some metabolic processes in organism is shown. The alteration of membrane enzyme activity under the influence of bile acids possessing the detergent properties may play an important role in different pathological conditions. The significance of bile acid metabolism under physiological and pathological conditions is underlined.