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1.
Viruses ; 14(7)2022 07 05.
Artigo em Inglês | MEDLINE | ID: mdl-35891460

RESUMO

Our effort in SARS-CoV-2 genomic surveillance in Brazil has detected the Alpha Variant of Concern with a predominance higher than 75% in the population of Ilhabela island (São Paulo State) at a time when the Gamma VOC was already predominating the mainland raised concerns for closer surveillance on this island. Therefore, we intensified the surveillance for 24 weeks by generating data from 34% of local positive cases. Our data show that the patterns of VOC predominance dynamics and infection rates were in general distinct from the mainland. We report here the first known case of Alpha predominance in a Brazilian population, a delay greater than 3 months for the Gamma to dominate the previous variants compared to the mainland, and a faster dispersion rate of Gamma and Delta VOCs compared to the mainland. Phylogenetic analysis revealed the SARS-CoV-2 transmission dynamics in Ilhabela were characterized by multiple independent introduction events of Gamma and Delta, with a few events of Alpha introduction, two of them followed by community transmission. This study evidenced the peculiar behavior of SARS-CoV-2 variants in an isolated population and brought to light the importance of specific programs for SARS-CoV-2 genomic surveillance in isolated populations.


Assuntos
COVID-19 , SARS-CoV-2 , Brasil/epidemiologia , COVID-19/epidemiologia , Humanos , Filogenia , SARS-CoV-2/genética
2.
Meat Sci ; 145: 209-219, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-29982075

RESUMO

The purpose of this research was to investigate the causes and consequences of pHu variations in beef cattle. A group of 176 Nellore beef cattle was evaluated and classified into two different pHu groups: High (≥6.0, N = 17) and Normal (<5.8, N = 159). Plasma concentrations of cortisol and adrenocorticotropic hormone, lactate and glycogen muscular content, meat color, shear force and Longissimus thoracis muscle proteomic profile were evaluated and compared between pHu groups. Muscle glycogen content, meat color and shear force statistically differed between pHu groups. Label-free quantitative proteomic analysis revealed ten differentially abundant proteins between pHu groups, involved in metabolic processes and muscle contraction, which also were significantly correlated with pHu. Thirty-six and 31 proteins were exclusively present in Normal and High pHu group, respectively, which were related to TCA cycle, cortisol production, calcium regulation, and antioxidant function. The MYH7, UGP2, H2AFJ and VDAC3 were identified as potential indicators of pHu variations. CALM and NNT appeared to be interesting proteins to understand the metabolic pathways behind pHu. Data are available via ProteomeXchange with identifier PXD009320.


Assuntos
Matadouros , Glicogênio/metabolismo , Hidrocortisona/sangue , Contração Muscular , Proteínas Musculares/metabolismo , Músculo Esquelético/fisiologia , Carne Vermelha/análise , Hormônio Adrenocorticotrópico/sangue , Animais , Antioxidantes/metabolismo , Cálcio/metabolismo , Bovinos , Ciclo do Ácido Cítrico , Cor , Humanos , Concentração de Íons de Hidrogênio , Ácido Láctico/sangue , Redes e Vias Metabólicas , Músculo Esquelético/metabolismo , Proteômica , Especificidade da Espécie , Estresse Mecânico , Estresse Psicológico/metabolismo
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