RESUMO
Doppler test in temporal arthritis. Prescriptions and limits The paper describes the Authors' personal experience in using the Doppler test for the diagnosis of temporal arthritis in a small group of patients clinically suspected of the pathology. The method has proved useful in the diagnosis and follow-up of the disease, but the diagnosis is confirmed by a biopsy of the temporal artery which still plays an important role.
Assuntos
Arterite de Células Gigantes/diagnóstico por imagem , Idoso , Biópsia , Feminino , Seguimentos , Arterite de Células Gigantes/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Fluxo Sanguíneo Regional , UltrassonografiaAssuntos
Malária/diagnóstico , Idoso , Animais , Anopheles , Coma/etiologia , Feminino , Humanos , Insetos Vetores , Itália , Malária/complicações , Malária/transmissão , Plasmodium falciparum , SenegalRESUMO
Clonidine, an effective antihypertensive drug acting on central presynaptic alpha 2-adrenoreceptors, is commonly used in opiate withdrawal. There is recent evidence of advantages in using clonidine also in alcohol withdrawal. The results of a randomized study on 44 alcoholics, admitted without withdrawal symptoms, are shown. The alcohol withdrawal syndrome appeared in 50% of the patients in the placebo group and in 9% of the clonidine treated patients. Clonidine is an effective tool in the hospital preventive treatment of alcohol withdrawal.
Assuntos
Clonidina/uso terapêutico , Etanol/efeitos adversos , Síndrome de Abstinência a Substâncias/prevenção & controle , Adulto , Pressão Sanguínea/efeitos dos fármacos , Ensaios Clínicos como Assunto , Clonidina/administração & dosagem , Clonidina/farmacologia , Feminino , Frequência Cardíaca/efeitos dos fármacos , Humanos , Masculino , Pessoa de Meia-Idade , Distribuição AleatóriaRESUMO
Non-ketotic hyperosmolar diabetic coma is a complication of diabetes characterised by extreme dehydration, plasmatic hyperosmolarity and the absence of ketosis. The mortality rate is very high, especially in elderly subjects with type II diabetes. A personal series of 12 cases is reported with an assessment of general features, triggering factors, biochemical parameters at onset and treatment given. The data confirm reports in the literature and the results show the therapeutic superiority of continuous endovenous infusions of insulin at 3-10 mu/hour over other treatment protocols.
Assuntos
Coma Diabético/diagnóstico , Coma Diabético/terapia , Coma Hiperglicêmico Hiperosmolar não Cetótico/diagnóstico , Coma Hiperglicêmico Hiperosmolar não Cetótico/terapia , Idoso , Diabetes Mellitus Tipo 2/complicações , Diabetes Mellitus Tipo 2/mortalidade , Dieta para Diabéticos , Feminino , Humanos , Coma Hiperglicêmico Hiperosmolar não Cetótico/mortalidade , Infusões Parenterais , Injeções Intramusculares , Insulina/administração & dosagem , Masculino , Pessoa de Meia-Idade , Sulfonamidas/administração & dosagem , Fatores de TempoRESUMO
A case of pseudohypoparathyroidism of characteristic phenotype and metabolism is described. The condition was diagnosed at over 50 years of age following the appearance of hypocalcaemia and calcification of basal ganglia which responded quickly to treatment with vitamin D and orally administered calcium. This case gives the opportunity to describe a rare hereditary disease and discuss which mechanisms triggered off the symptomatology: mechanisms which involve PTH, the action of which is still not fully known.
Assuntos
Pseudo-Hipoparatireoidismo/genética , Calcinose/etiologia , Feminino , Deformidades Congênitas do Pé , Deformidades Congênitas da Mão , Articulação do Quadril , Humanos , Hidroxicolecalciferóis/uso terapêutico , Cariotipagem , Pessoa de Meia-Idade , Osteoartrite/complicações , Fenótipo , Pseudo-Hipoparatireoidismo/tratamento farmacológico , Osso TemporalRESUMO
A case of Still's disease is presented that demonstrates the uncertain prognosis and the duration of the treatment required to prevent recurrences. The importance of frequent check-ups is also emphasised.
Assuntos
Artrite Juvenil/genética , Corticosteroides/uso terapêutico , Adulto , Artrite Juvenil/tratamento farmacológico , Artrite Juvenil/fisiopatologia , Humanos , Cariotipagem , Masculino , RecidivaRESUMO
The aim of this work was the evaluation of the possible mutagenic effect of an antibiotic, the Cloxacillin. Therefore the authors have performed the analysis of the chromosomal alterations and the study of the SCE (Sister Chromatid Exchanges) induced with the exposition of cultures of lymphocytes to different concentrations of this drug. The work reveals that Cloxacillin induces chromosomal alterations at high concentrations, while at concentrations similar to its therapeutic levels the drug does not seem to interfere with human DNA.