The "resin-capture-release" hybrid technique: a merger between solid- and solution-phase synthesis.

A polymer-assisted organic synthesis that combines the concept of solid-phase synthesis with the idea of polymer-supported scavenging reagents has recently appeared on the chemistry scene. This technique has frequently been termed the "resin-capture-release" methodology and is initiated by the immobilization of a small molecule on a polymeric support. This intermediate is subjected to a second transformation by adding a new reaction partner in solution. This reactant plays two roles: a) the chemical alteration of the polymer-bound intermediate and b) the simultaneous release of this reaction product from the resin back into solution. This new concept is presented and future prospects are discussed.

Stable Polymer-Bound Iodine Azide.

1,2-Azido-iodination of a wide range of alkenes under very mild conditions can be achieved by using a novel iodate(I) reagent, a stable and storable polymer-bound iodine azide, which is available in two steps (see scheme). Simple work-up and convenient use in automated parallel synthesis are important features of this polymer-bound reagent.