1.
Curr Top Med Chem
; 2(3): 229-46, 2002 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11944818
RESUMO
Increasing insight into the genetics and molecular biology of cancer has resulted in the identification of an increasing number of potential molecular targets for anti-cancer drug discovery and development. These targets can be approached through exploitation of emerging structural biology, "rational" drug design, screening of chemical libraries, or a combination of these methods. In this article we discuss the application of high-throughput screening to anti-cancer drug discovery, with special reference to approaches used at the U.S. National Cancer Institute.