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Curr Top Med Chem ; 2(3): 229-46, 2002 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-11944818

RESUMO

Increasing insight into the genetics and molecular biology of cancer has resulted in the identification of an increasing number of potential molecular targets for anti-cancer drug discovery and development. These targets can be approached through exploitation of emerging structural biology, "rational" drug design, screening of chemical libraries, or a combination of these methods. In this article we discuss the application of high-throughput screening to anti-cancer drug discovery, with special reference to approaches used at the U.S. National Cancer Institute.


Assuntos
Antineoplásicos/farmacologia , Ensaios de Seleção de Medicamentos Antitumorais/métodos , Algoritmos , Animais , Técnicas de Química Combinatória/métodos , Desenho de Fármacos , Humanos
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