RESUMO
OBJECTIVES: To asses risk factors for a first thrombotic event in antiphospholipid antibody (aPL) positive carriers and evaluate the efficacy of prophylactic treatments. METHODS: Recruitment criteria were age 18-65 years, no history of thrombosis, positivity for lupus anticoagulant and/or IgG/IgM anticardiolipin antibody (aCL) on > or =2 occasions at least 6 weeks apart. Demographic, laboratory and clinical parameters were collected at enrolment and at the time of the thrombotic event. RESULTS: 370 patients/subjects (mean (SD) age 34 (9.9) years) were analysed retrospectively for a mean (SD) follow-up of 59.3 (45.5) months. Thirty patients (8.1%) developed a first thrombotic event during follow-up. Hypertension and medium/high levels of IgG aCL were identified by multivariate logistic regression analysis as independent risk factors for thrombosis. Thromboprophylaxis during high-risk and long-term periods was significantly protective. CONCLUSIONS: Hypertension or medium/high titres of IgG aCL are risk factors for a first thrombotic event in asymptomatic aPL carriers and primary prophylaxis is protective.
Assuntos
Anticorpos Antifosfolipídeos/sangue , Síndrome Antifosfolipídica/imunologia , Heterozigoto , Trombose/etiologia , Adolescente , Adulto , Idoso , Anticorpos Anticardiolipina/sangue , Síndrome Antifosfolipídica/genética , Métodos Epidemiológicos , Feminino , Humanos , Hipertensão/complicações , Imunoglobulina G/sangue , Masculino , Pessoa de Meia-Idade , Trombose/imunologia , Trombose/prevenção & controle , Adulto JovemRESUMO
The authors examined the microcirculatory system alterations which are present in case of arterial hypertension. These alterations consist of an increase in capillary peripheral resistances and in total blood viscosity, of a reduction in red cell deformability and of a vasomotion alteration. The authors evaluated the opportunities of a therapeutic intervention with hypotensive treatments also affecting the microcirculatory system in hypertensive patients with or without associated diabetes mellitus.
Assuntos
Viscosidade Sanguínea , Túnica Conjuntiva/irrigação sanguínea , Hipertensão/sangue , Diabetes Mellitus Tipo 2/sangue , Diabetes Mellitus Tipo 2/fisiopatologia , Hemodinâmica , Humanos , Hipertensão/fisiopatologia , Fluxometria por Laser-Doppler , Microcirculação/fisiopatologia , Resistência VascularRESUMO
An intraoral device has been experimented to stabilize oro-gastric or oro-jejunal feeding tubes in low birth weight newborns.
