RESUMO
Insulinomas are extremely rare pancreatic endocrine tumors. The tumor is characterized by endogenous hypersecretion of insulin and ensuing development of symptoms of neuroglycopenia and the catecholaminergic response. Symptoms may not always be present, particularly in patients compensating appropriately with increased appetites and caloric intake due to low glucose levels. Early localization of the disease is essential to prevent lethal hypoglycemia and timely treatment. This case report and literature review depict the case of a pancreatic insulinoma in an 86-year-old female, an exceptionally rare presentation based on age and absence of clinical symptoms for one or more years prior to hospitalization. Despite its rarity, similar presentations have been reported in the literature and are further outlined with characteristics and treatment plans. This case highlights a unique presentation of insulinoma and suggests the need for clinical vigilance and further study. It also discusses diagnosis, localization, and management of this uncommon disease in patients above the age of seventy-five.
RESUMO
Blastomycosis is a well known infection caused by Blastomyces dermatitidis. It appears usually as a mild and self-limited disease, but disseminated cases are seen, especially in immunocompromised patients. In organ transplant recipients, fungal infections play an important role and in some cases can be fatal, but blastomycosis is a rare and uncommon condition in this setting and specifically in renal transplant patients. Its occurrence is probably due to previous exposure, but sometimes there is no clear history that indicates such exposure. We describe a patient who underwent a renal transplant and developed pulmonary blastomycosis.
