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1.
Biosens Bioelectron ; 79: 9-14, 2016 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-26686917

RESUMO

Lower genital tract infections caused by both sexually and not-sexually transmitted pathogens in women are a key public health priority worldwide, especially in developing countries. Since standard analyses are time-consuming, appropriate therapeutic intervention is often neglected or delayed. Lab-on-chips and biosensors open new perspectives and offer innovative tools to simplify the diagnosis by medical staff, especially in countries with inadequate resources. Here we report a biosensing platform based on Electrochemical Impedance Spectroscopy (EIS) that allows multiplexed detection of Candida albicans, Streptococcus agalactiae and Chlamydia trachomatis with a single biochip, enabling a quick screening thanks to the presence of different immobilized antibodies, each specific for one of the different target pathogens.


Assuntos
Candida albicans/isolamento & purificação , Candidíase/diagnóstico , Infecções por Chlamydia/diagnóstico , Chlamydia trachomatis/isolamento & purificação , Dispositivos Lab-On-A-Chip , Infecções Estreptocócicas/diagnóstico , Streptococcus agalactiae/isolamento & purificação , Anticorpos Imobilizados/química , Técnicas Biossensoriais/instrumentação , Espectroscopia Dielétrica/instrumentação , Desenho de Equipamento , Feminino , Humanos , Imunoensaio/instrumentação , Vaginose Bacteriana/diagnóstico
2.
Analyst ; 138(18): 5404-10, 2013 Sep 21.
Artigo em Inglês | MEDLINE | ID: mdl-23884165

RESUMO

Prostate cancer affects a large part of the western male population. The need for an early and accurate detection is thus a great challenge in common clinical practice, but the lack of specificity of the serum marker PSA (Prostate Specific Antigen) is a serious problem since its increased concentration can be related to several abnormalities. PSA, however, is found in serum in both a free and a complexed form with other proteins and the percentage amount of unbound PSA (the free-to-total PSA ratio) can be employed to distinguish prostate cancer from benign prostatic conditions, and also to predict the future risk of prostate cancer. To improve the operating characteristics of current PSA tests and to provide a clinical tool able to run label-free and sensitive analysis, we thus developed a biosensing platform based on Electrochemical Impedance Spectroscopy (EIS), which allows the contemporary detection of free and total PSA on a single biochip, enabling a quick screening for the risk of prostate cancer thanks to the presence of two different immobilized antibodies specific for the different antigens researched.


Assuntos
Espectroscopia Dielétrica/instrumentação , Técnicas Analíticas Microfluídicas/instrumentação , Antígeno Prostático Específico/análise , Neoplasias da Próstata/diagnóstico , Humanos , Masculino
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