CGS 10746B, a novel dopamine release inhibitor, blocks the establishment of cocaine and MDMA conditioned place preferences.

Cocaine and methylenedioxymethamphetamine (MDMA), two drugs self-administered by humans and laboratory animals, have previously been shown to produce conditioned place preferences (CPPs) among rats, an index of drug-reward relevant events. Both of these agents increase functional levels of dopamine that may be critical to their rewarding properties. Here, the effects of doses of CGS 10746B, an agent reported to attenuate the release of dopamine without occupying dopamine receptors, are assessed on cocaine and MDMA's ability to produce a CPP. CGS 10746B dose dependently blocked the establishment of a MDMA CPP. A 30 mg/kg dose of CGS 10746B, which completely blocked the MDMA CPP, also blocked the establishment of a cocaine CPP. Release of dopamine appears critical to the ability of these agents to establish a CPP.

Of red planets and indigo computers: Mars database visualization as an example of platform downsizing.

The last decade has witnessed tremendous advancements in the computer hardware and software used to perform scientific visualization. In this paper, we consider how the visualization of a particular data set, the digital terrain model derived from the Viking orbiter imagery, has been realized in four distinct projects over this period. These examples serve to demonstrate how the vast improvements in computational performance both decrease the cost of such visualization efforts and permit an increasing level of interactivity. We then consider how even today's graphical systems require the visualization designer to make intelligent choices and tradeoffs in database rendering. Finally, we discuss how insights gleaned from an understanding of human visual perception can guide these design decisions, and suggest new options for visualization hardware and software.

High refresh rate and oculomotor adaptation facilitate reading from video displays.

Reading from a video display terminal (VDT) was tested at screen refresh rates of 500 Hz and 60 Hz. Reading was initially 8 words/min (3.05%) faster at 500 Hz. A hypothesis that reading rate on VDTs is limited by stimulus availability accounts for the difference. When the eye reaches a new fixation position, it 'parks' until a sample of text appears at the fovea. Then processing resumes in the normal way. This idea, combined with the 500-Hz reading data, can predict reading rate at any refresh rate, and is quantitatively confirmed by the reading rate at 60 Hz. The difference in reading rates disappeared for the second half of the text, as a result of differences between frequencies of eye movements in the two refresh conditions. From the first half to the second, subjects at 60 Hz made more large forward saccades and fewer small reverse saccades. Both changes make sampling of the text more sparse, compensating for the dead time between samples. Subjects were unaware of refresh conditions, differences in their reading rates, and types of eye movements they generated. Reading from a continuously illuminated active-matrix display is slightly faster than from a comparable VDT.

Rotational and translational components of motion parallax: observers' sensitivity and implications for three-dimensional computer graphics.

The motion of objects during motion parallax can be decomposed into 2 observer-relative components: translation and rotation. The depth ratio of objects in the visual field is specified by the inverse ratio of their angular displacement (from translation) or equivalently by the inverse ratio of their rotations. Despite the equal mathematical status of these 2 information sources, it was predicted that observers would be far more sensitive to the translational than rotational component. Such a differential sensitivity is implicitly assumed by the computer graphics technique billboarding, in which 3-dimensional (3-D) objects are drawn as planar forms (i.e., billboards) maintained normal to the line of sight. In 3 experiments, observers were found to be consistently less sensitive to rotational anomalies. The implications of these findings for kinetic depth effect displays and billboarding techniques are discussed.

Opioidergic modulation of cocaine conditioned place preferences.

Recent studies have begun to assess the utility of opioid agonists and antagonists for the treatment of cocaine addiction. The present studies assess the effects of naltrexone or methadone on cocaine's reinforcing properties using the conditioned place preference (CPP) test. The results indicate that a 56 mg/kg dose of naltrexone, given 4 hr prior to conditioning, attenuates cocaine's CPP. In contrast, methadone (8 mg/kg), given 1 hr prior to conditioning, enhanced cocaine's reinforcing properties. These results support the suggestion that opioid antagonists may have clinical utility in treating cocaine addiction. The results with methadone lead to a possible explanation for the higher rates of cocaine use in methadone-treated heroin addicts.