1.
Am J Trop Med Hyg
; 24(2): 179-82, 1975 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-1091166
RESUMO
An in vivo screening system is described in which drugs administered to rats or mice and challenged with sporozoites are evaluated for their antimalarial properties (causal prophylaxis, suppression, therapy) by the presence or absence of exoerythrocytic forms and parasitemia. The system is composed of A/J mice, Sprague-Dawley rats, Plasmodium berghei, and Anopheles stephensi. Good correlation has been found between test results and practical application.