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1.
Neurotoxicology ; 34: 33-41, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-23110976

RESUMO

A range of studies has been conducted on the detrimental effects of lead in mining and smelting communities. The neurocognitive and behavioural health effects of lead on children are well known. This research characterized the conjoint influence of lead exposure and home enriched environment on neurocognitive function and behaviour for first-grade children living in a Mexican lead smelter community. Structural equation models were used for this analysis with latent outcome variables, Cognition and Behaviour, constructed based on a battery of assessments administered to the first-grade children, their parents, and teachers. Structural equation modelling was used to describe complex relationships of exposure and health outcomes in a manner that permitted partition of both direct and indirect effects of the factors being measured. Home Environment (a latent variable constructed from information on mother's education and support of school work and extracurricular activities), and child blood lead concentration each had a main significant effect on cognition and behaviour. However, there were no statistically significant moderation relationships between lead and Home Environment on these latent outcomes. Home Environment had a significant indirect mediation effect between lead and both Cognition and Behaviour (p-value<0.001). The mediation model had a good fit with Root Mean Square Error of Approximation <0.0001 and a Weighted Root Mean Square Residual of 0.895. These results were highly significant and suggest that Home Environment has a moderate mediation effect with respect to lead effects on Behaviour (ß=0.305) and a lower mediation effect on Cognition (ß=0.184). The extent of home enrichment in this study was most highly related to the mother's support of schoolwork and slightly less by the mother's support of extracurricular activities or mother's education. Further research may be able to develop approaches to support families to make changes within their home and child rearing practices, or advocate for different approaches to support their child's behaviour to reduce the impact of lead exposure on children's cognitive and behavioural outcomes.


Assuntos
Comportamento Infantil/efeitos dos fármacos , Cognição/efeitos dos fármacos , Exposição Ambiental/efeitos adversos , Poluentes Ambientais/efeitos adversos , Intoxicação do Sistema Nervoso por Chumbo na Infância/etiologia , Chumbo/efeitos adversos , Metalurgia , Mineração , Características de Residência , Carga Corporal (Radioterapia) , Distribuição de Qui-Quadrado , Criança , Desenvolvimento Infantil/efeitos dos fármacos , Educação Infantil , Pré-Escolar , Estudos Transversais , Escolaridade , Poluentes Ambientais/sangue , Humanos , Chumbo/sangue , Intoxicação do Sistema Nervoso por Chumbo na Infância/sangue , Intoxicação do Sistema Nervoso por Chumbo na Infância/psicologia , Modelos Logísticos , México , Relações Mãe-Filho , Análise Multivariada , Testes Neuropsicológicos , Apoio Social
2.
Environ Res ; 2011 Nov 14.
Artigo em Inglês | MEDLINE | ID: mdl-22088604

RESUMO

This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.

3.
Am J Public Health ; 101 Suppl 1: S156-60, 2011 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-21836120

RESUMO

The Environmental Protection Agency measures the success or failure of Superfund site remediation efforts against remedial action objectives (RAOs). RAOs are frequently based on environmental contaminant concentrations, but with lead exposure, blood lead levels from the population at risk are often used. Although childhood lead screening is an important public health tool, an RAO based on child blood lead levels raises ethical concerns: public health efforts that are more reactive than preventive, a blood lead standard (10 µg/dL) that may not be fully protective, the use of a measure whose validity and reliability may be easily compromised, and exacerbation of environmental injustice and systematic disadvantages. The example of Bunker Hill mine, Kellogg, Idaho, allowed an examination of these ethical concerns.


Assuntos
Recuperação e Remediação Ambiental/ética , Intoxicação por Chumbo/sangue , Chumbo/sangue , Mineração , United States Environmental Protection Agency , Criança , Pré-Escolar , Monitoramento Ambiental/ética , Disparidades nos Níveis de Saúde , Humanos , Idaho , Lactente , Chumbo/toxicidade , Concentração Máxima Permitida , Justiça Social , Estados Unidos
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