Assuntos
Carcinoma in Situ , Infecções por Papillomavirus , Lesões Intraepiteliais Escamosas , Neoplasias Vulvares , Acetamidas , Carcinoma in Situ/patologia , Feminino , Papillomavirus Humano 16 , Humanos , Morfolinas , Pomadas , Papillomaviridae , Infecções por Papillomavirus/complicações , Infecções por Papillomavirus/tratamento farmacológico , Infecções por Papillomavirus/patologia , Piridinas , Neoplasias Vulvares/patologiaRESUMO
BACKGROUND: The effect of smoking on human papillomavirus (HPV) activity and subsequent dysplasia and neoplasia remains controversial. OBJECTIVE: To determine any reported effects of smoking on either HPV activity or HPV-related dysplasia/cancer using retrospective analysis of the literature from 1966 through 1998 via Toxline and PubMed to search for "smoking," "papillomavirus," and "cancer." CONCLUSION: Several recent large studies demonstrated that smoking was associated with a greater incidence of cervical, vulvar, penile, anal, oral, and head and neck cancer in a dose-dependent fashion, while other studies did not show any correlation between smoking and cervical dysplasia after multivariate adjustment. Recent studies have also indicated that smoking may be more closely related to high-grade lesions of the cervix and vulva. These data provide evidence of an association between HPV, smoking, and cancer. Progression of dysplasia likewise seems to be associated with smoking. Several groups have attempted to discern whether the connection between smoking and cervical cancer is from local immunosuppression and/or from direct carcinogenic effects.
Assuntos
Neoplasias/etiologia , Papillomaviridae , Infecções por Papillomavirus/complicações , Fumar/efeitos adversos , Infecções Tumorais por Vírus/complicações , Neoplasias do Ânus/etiologia , Carcinoma in Situ/etiologia , Condiloma Acuminado/etiologia , Feminino , Neoplasias de Cabeça e Pescoço/etiologia , Humanos , Neoplasias Pulmonares/etiologia , Masculino , Neoplasias Bucais/etiologia , Análise Multivariada , Razão de Chances , Neoplasias Penianas/etiologia , Prognóstico , Estudos Retrospectivos , Fatores de Risco , Displasia do Colo do Útero/etiologia , Neoplasias do Colo do Útero/etiologia , Neoplasias Vulvares/etiologiaAssuntos
Produtos do Gene tat/genética , Genes Virais/genética , HIV-1/genética , Herpesvirus Humano 8/genética , Sarcoma de Kaposi/genética , Transcrição Gênica , Regulação Neoplásica da Expressão Gênica/genética , Regulação Viral da Expressão Gênica/genética , Humanos , Linfoma , Reação em Cadeia da Polimerase , Células Tumorais Cultivadas , Produtos do Gene tat do Vírus da Imunodeficiência HumanaRESUMO
Mycobacterium kansasii infections of the skin have been described in 31 previously published cases. The median age of these patients is 43 years, and male patients are more frequently affected than female patients. Most patients (72%) with this infection have some alteration of their immune status, but disseminated infection is relatively uncommon (22%). We present the first reported case of cutaneous M. kansasii infection in a patient with previously diagnosed systemic lupus erythematosus. The clinical presentation is similar to that expected in lupus profundus. While the duration of treatment is long (18 months), this case demonstrates that rifampin combined with at least 2 other antibiotics can provide excellent results. Clarithromycin has demonstrated encouraging in vitro results against M. kansasii but has not yet been reported for treatment of cutaneous infections.
Assuntos
Lúpus Eritematoso Sistêmico/diagnóstico , Infecções por Mycobacterium não Tuberculosas/diagnóstico , Mycobacterium kansasii , Infecções Oportunistas/diagnóstico , Adulto , Diagnóstico Diferencial , Feminino , Humanos , Lúpus Eritematoso Sistêmico/patologia , Masculino , Pessoa de Meia-Idade , Infecções por Mycobacterium não Tuberculosas/patologia , Infecções Oportunistas/patologia , Pele/patologiaRESUMO
BACKGROUND: The histopathologic effects of curative doses of radiation therapy on cutaneous squamous cell carcinoma (SCC) have not been well described in the dermatologic literature. OBJECTIVE: To understand the histopathologic process of cutaneous SCC involution following radiation treatment. METHODS: Hematoxylin-eosin stain and immunoperoxidase stains for keratin were performed on tissue from the site of a primary cutaneous SCC 2 months after completion of fractionated radiation therapy (7000 cGy total) but prior to clinical involution. RESULTS: Histopathological examination of the irradiated SCC revealed dermal keratin pearls and keratinocytic necrosis resembling apoptosis as well as inflammation and foreign body giant cell reaction. Immunoperoxidase staining for keratin revealed cellular remnants of cutaneous SCC without intact keratinocytic nuclei within giant cells. CONCLUSION: Complete clinical resolution of the SCC over the next several weeks without recurrence after 15 months confirmed the histopathologic findings of tumor destruction by primary radiation therapy.