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2.
J Nat Prod ; 72(7): 1355-6, 2009 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-19469512

RESUMO

Pronuciferine N-oxide (1), a proaporphine N-methyl-N-oxide alkaloid, along with the parent alkaloid pronuciferine (2) were isolated from Berberis coletioides. The structure of the new compound was determined by spectroscopic evidence. Compound 1 is the first naturally occurring proaporphinoid alkaloid with an N-oxide functionality.


Assuntos
Berberis/química , Compostos de Espiro/isolamento & purificação , Alcaloides/química , Chile , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Compostos de Espiro/química
3.
Phytochemistry ; 69(16): 2815-9, 2008 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-18851862

RESUMO

A bio-guided screening against influenza A virus (FLUAV) was carried out with seven Euphorbiaceae species. The results showed that chromatographic fractions from Phyllantus niruri, Euphorbia pulcherrima and Codiaeum variegatum had relevant anti-FLUAV activity, although only chromatographical subfractions from C. variegatum kept the activity. From this plant, the active compound against FLUAV was isolated. Its structure was assigned as 2-(3,4,5)-trihydroxy-6-hydroxymethyltetrahydropyran-2-yloxymethyl)acrylonitrile (1) on the basis of NMR, mass spectrometry and X-ray diffraction analysis. The compound displayed virucidal activity without impairment of haemagglutination properties of the used virus strain. This is the first report indicating antiviral activity of a cyanoglucoside.


Assuntos
Acrilonitrila/análogos & derivados , Antivirais/farmacologia , Euphorbiaceae/química , Glucosídeos/farmacologia , Hexoses/farmacologia , Vírus da Influenza A/efeitos dos fármacos , Acrilonitrila/química , Acrilonitrila/isolamento & purificação , Acrilonitrila/farmacologia , Animais , Antivirais/química , Antivirais/isolamento & purificação , Linhagem Celular , Cães , Glucosídeos/química , Glucosídeos/isolamento & purificação , Hexoses/química , Hexoses/isolamento & purificação , Testes de Sensibilidade Microbiana , Ressonância Magnética Nuclear Biomolecular , Difração de Raios X
4.
J Nat Prod ; 70(7): 1173-9, 2007 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-17616227

RESUMO

The aerial parts of Mikania campanulata Gardner afforded the nine new eudesmanolides (1S,4S,5S,6S,7S,10R)-1-hydroxy-15-acetoxyeudesm-11(13)-en-6,12-olide (1), (1S,4S,5S,6S,7S,10R)-1,4-dihydroxy-15-acetoxyeudesm-11(13)-en-6,12-olide (2), (1R,4S,5S,6S,7S,10R)-1,4-dihydroxy-15-acetoxyeudesm-11(13)-en-6,12-olide (3), (1R,4S,5S,6S,7S,10R)-1-hydroxy-4,15-diacetoxyeudesm-11(13)-en-6,12-olide (4), (1S,4R,5S,6S,7S,10R)-1,15-diacetoxy-4-hydroxyeudesm-11(13)-en-6,12-olide (5), (1S,5S,6S,7S,10R)-1-hydroxy-15-acetoxyeudesma-4(15),11(13)-dien-6,12-olide (6), (1S,5S,6S,7S,10R)-1,15-dihydroxyeudesma-3,11(13)-dien-6,12-olide (7a), (1S,2R,5S,6S,7S,10R)-1,2,15-trihydroxyeudesma-3,11(13)-dien-6,12-olide (8a), and (1R,6S,7S,10R)-1,15-dihydroxyeudesma-4,11(13)-dien-6,12-olide (9a), among which the last three were characterized as their corresponding peracetates (7b-9b). The structures of 1-6 and 7b-9b were elucidated using 1D and 2D NMR measurements, while that of major constituent 1 was confirmed by single-crystal X-ray diffraction analysis, and its absolute configuration evidenced from vibrational circular dichroism measurements, which were compared to results obtained from density functional theory calculations. The chemistry of the large genus Mikania is briefly analyzed.


Assuntos
Mikania/química , Plantas Medicinais/química , Sesquiterpenos/química , Sesquiterpenos/isolamento & purificação , Argentina , Dicroísmo Circular , Cristalografia por Raios X , Conformação Molecular , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Estereoisomerismo
5.
Magn Reson Chem ; 43(3): 256-60, 2005 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-15625718

RESUMO

Phenazopyridine hydrochloride (1), a drug in clinical use for many decades, and some derivatives were studied by one- and two-dimensional (1)H, (13)C and (15)N NMR methodology. The assignments, combined with DFT calculations, reveal that the preferred protonation site of the drug is the pyridine ring nitrogen atom. The chemoselective acetylation of phenazopyridine (2) and its influence on the polarization of the azo nitrogen atoms were evidenced by the (15)N NMR spectra. Molecular calculations of the phenazopyridines 2-4 show that the pyridine and phenyl groups are oriented in an antiperiplanar conformation with intramolecular hydrogen bonding between the N-b atom and the C-2 amino group preserving the E-azo stereochemistry.


Assuntos
Isótopos de Carbono , Espectroscopia de Ressonância Magnética/métodos , Fenazopiridina/análise , Fenazopiridina/química , Prótons , Espectroscopia de Ressonância Magnética/normas , Conformação Molecular , Isótopos de Nitrogênio , Fenazopiridina/normas , Valores de Referência
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