RESUMO
This study evaluates a correlation between family history, micronutrients intake, and alternative therapies with genetic instability, before and during breast cancer treatment. For this study, a total of 150 women were selected. Among those, 50 women were breast cancer patients on chemotherapy, while 50 breast cancer patients were on radiotherapy, and 50 were healthy females. All the participants signed the informed consent form and answered the public health questionnaire. Samples of buccal epithelial and peripheral blood cells were collected and analyzed through micronucleus and comet assays. The cells were evaluated for apoptosis and DNA damage. Results showed the association of patients' family history with an increase in toxicogenetic damage before and during cancer therapy. On the other hand, patients with late-onset cancer also presented genetic instability before and during therapy, along with those who did not take sufficient vegetables and alternative therapies. A positive correlation was observed between the genetic instability and alternative therapies, while inverse correlation was recorded with the vegetable consumption. Results clearly explain that the nutritional aspects and alternative therapies influence the genetic instability before and during cancer therapies especially in radiotherapy treated patients. Our data could be used for the monitoring therapies and management of breast cancer patients.
Assuntos
Neoplasias da Mama/genética , Neoplasias da Mama/fisiopatologia , Terapias Complementares , Dieta , Instabilidade Genômica , Anamnese , Estudos de Casos e Controles , Ensaio Cometa , Feminino , Frutas , Predisposição Genética para Doença , Humanos , Pessoa de Meia-Idade , VerdurasRESUMO
ETHNOPHARMACOLOGICAL RELEVANCE: Aloe vera is a widely used medicinal plant for its various biological activities. This study evaluate possible mutagenic and healing effects of the aqueous extract of A. vera (AEAV) in mice and its oxidant/antioxidant potential in different proficient and deficient Saccharomyces cerevisiae strains. MATERIAL AND METHODS: The AEAV was topically treated on the wounded skin surface of male albino mice at doses of 10 and 50â¯mg/kg for seven successive days. The control group was similarly treated with 0.9% NaCl solution. For oxidative/anti-oxidative evaluation, both proficient and deficient strains of S. cerevisiae [cytoplasmic and mitochondrial superoxide dismutase mutant (SOD: Sod1Δ and Sod2Δ), cytoplasmic catalase mutant (CAT: Cat1Δ)], two double defective mutants of Sod1 and Sod2 and Sod1 and Cat1 genes along with a wild-type strains were used. RESULTS: The healing property of AEAV was observed at the dose of 50â¯mg/kg but at the same dose it showed mutagenic and cytotoxic effects in peripheral blood. AEAV did not produce the oxidizing effect, except in the mutated CAT strain at highest concentration (50â¯mg/kg). CONCLUSION: The high concentration of AEAV showed mutagenicity and cytotoxicity. Beside, the healing capacity is believed to be due to its anti-oxidative defense mechanism.
Assuntos
Aloe , Antioxidantes/farmacologia , Mutagênicos/farmacologia , Extratos Vegetais/farmacologia , Cicatrização/efeitos dos fármacos , Animais , Células da Medula Óssea/efeitos dos fármacos , Proliferação de Células/efeitos dos fármacos , Masculino , Camundongos , Testes para Micronúcleos , Estresse Oxidativo/efeitos dos fármacos , Saccharomyces cerevisiae/efeitos dos fármacos , Pele/lesões , Pele/patologiaRESUMO
Os paragangliomas do corpo carotídeo são lesões raras originadas em estruturas microscópicas associadas ao sistema nervoso autônomo, nas regiões para-axiais do tronco, vizinhança dos arcos branquioméricos e periferia do SNA, os paragânglios. A presença de lesão bilateral é rara. Os autores relatam dois casos de paraganglioma bilateral, onde se avaliam suas características clínico-epidemiológicas e o tratamento cirúrgico.
The carotid paragangliomas body injuries are rare and originated from microscopic structures associated with the autonomic nervous system in the torso paraaxial regions, neighbourhood of the branchiomeric arches and the periphery of the ANS, the paraganglia. The presence of bilateral injury is rare. The authors report two cases of bilateral paraganglioma, evaluating the clinical and epidemiological characteristics and surgical treatment.
RESUMO
Aneurisma extracraniano de artéria carótida interna é um evento incomum, podendo produzir complicações neurológicas graves. Relata-se um caso de um paciente do gênero feminino com 51 anos de idade que apresentou massa pulsátil e semifixa em região cervical esquerda nível II, que revelou ser um aneurisma extracraniano de carótida interna, sendo submetida ao tratamento cirúrgico.
Extracranial aneurysm of the internal carotid artery is an unusual event that can produce neurological complications. We report a case of a 51-year-old female patient who presented a pulsate and partially fixed mass in left cervical region level II, that unveil to be an aneurysm extracranial of internal carotid artery; undergoing the surgery treatment.
RESUMO
Implantes osteointegrados foram inseridos no rebordo orbitário superior de um paciente que perdera o globo ocular em decorrência de um carcinoma epidermóide na pálpebra esquerda. A retenção da prótese através de munhões bola facilita o seu uso e aumenta a confiança do paciente para suas atividades habituais, diminuindo o risco de queda ou deslocamento da mesma. Este caso faz parte de um programa desenvolvido no Hospital São Marcos em Terezina para reabilitação de deformidades faciais em pacientes vítimas de neoplasias. É desenvolvido por uma equipe multiplidisciplinar, incluindo cirurgiões-dentistas de várias especialidades e médicos
