RESUMO
Mucormycosis is a rare opportunistic fungal infection caused by saprophytic zygomycetes. These fungal infections are caused by members of the mucorales. The clinical importance of zygomycosis, an emerging and frequently fatal mycotic disease, has increased during recent years, due to several risk factors such as (a) the use of broad-spectrum antibiotic, (b) use of empirical antifungal treatment (mainly triazoles), and (c) aggressive chemotherapy and sustained leucopenia (i.e., peripheral stem cell transplantation). An almost fulminant pneumonia caused by Syncephalastrum racemosum in an immunocompromised patient with an aggressive non-Hodgkin lymphoma (NHL) is described. Despite treatment with amphotericin B, deoxycholate, caspofungin, and surgical resection of fungal bodies from both lungs, and survival of 10 months without relapsing from fungal infection, the patient died due to hematological complications from an unresponsive disease. Herein is the description of the first case of pulmonary infection caused by Syncephalastrum racemosum.
Assuntos
Pneumopatias Fúngicas/diagnóstico , Pneumopatias Fúngicas/patologia , Linfoma não Hodgkin/complicações , Mucorales/isolamento & purificação , Mucormicose/diagnóstico , Mucormicose/patologia , Adulto , Antifúngicos/uso terapêutico , Desbridamento , Feminino , Histocitoquímica , Humanos , Hospedeiro Imunocomprometido , Pneumopatias Fúngicas/microbiologia , Pneumopatias Fúngicas/terapia , Microscopia , Mucormicose/microbiologia , Mucormicose/terapiaRESUMO
Screening of a marine natural products library afforded three new analogues of the tetronic acid containing polyketide abyssomicin family and identified abyssomicin 2 as a selective reactivator of latent HIV virus. Examination of the mode of action of this new latent HIV reactivating agent demonstrated that it functions via a distinct mechanism compared to that of existing reactivating agents and is effective at reactivating latent virus in a subset of primary patient cell lines.
