Radiologic adjacent segment degeneration 2 years after lumbar fusion for degenerative spondylolisthesis.

INTRODUCTION: Lumbar fusion is now a currently accepted treatment for degenerative lumbar spondylolisthesis (DLSP), but may induce adjacent segment degeneration (ASD). The present study hypothesis was that there are radiological parameters associated with ASD. The study objective was to determine predictive factors of ASD. MATERIAL AND METHODS: A single-center retrospective study included patients operated on between 2006 and 2013 for DLSP. Radiological parameters were analyzed on preoperative, immediate postoperative and final follow-up lateral X-ray. ASD was defined by the following adjacent segment criteria:>3mm anteroposterior translation,>10° segmental kyphosis, or>50% loss of disc height. RESULTS: One hundred and seven patients were included: 79% female; mean age, 67±10.2 years. Fusion involved 1 level in 67% of cases and 2 or more in 33%, with transforaminal lumbar interbody fusion (TLIF) in 27% of cases. There was overall significant gain in lumbar lordosis (mean, 3.1°; P=0.04). At a mean 27.8 months' follow-up, 29% of cases showed ASD and 10% required surgical reintervention. Preoperative anterior imbalance and long fusion (>2 levels) were significantly associated with ASD (OR=2.81, 95% CI [1.17-6.74] versus OR=2.76, 95% CI [1.15-6.63]). There were no significant differences according to postoperative radiological parameters, or to TLIF (OR=1.8, 95% CI [0.7-4.4]). CONCLUSION: Twenty-nine percent of patients developed ASD, with a surgical revision rate of 10%. ASD risk factors comprised high number of instrumented levels and preoperative sagittal imbalance. LEVEL OF EVIDENCE: IV, retrospective cohort.

Particularities of anterior fusion in L4-L5 isthmic spondylolisthesis.

PURPOSE: L4-L5 isthmic spondylolisthesis may be associated with lumbosacral transitional vertebrae (LSTV) and altered venous vascular anatomy. The objectives of this study were to describe the anatomical characteristics of L4-L5 ISPL and the intraoperative difficulties encountered during the approach for anterior lumbar interbody fusion (ALIF). METHODS: This is a retrospective review of 20 ALIFs for L4-L5 ISPL. The anatomy of the common iliac veins confluence and the position of L4-L5 with respect to the projection of the iliac crest were analysed on CT-scan. Intraoperative difficulties were noted. RESULTS: A LSTV was present in 60% of cases, associated with abnormally distal positioning of L4-L5 below the projection of the iliac crest. The common iliac veins confluence was abnormally proximal compared to L4-L5. No complication was noted, even if the approach was unusually difficult in 11 cases. DISCUSSION: Anterior lumbotomies are difficult because the left common iliac vein courses transversely across the left anterolateral aspect of the L4-L5 disc and L5 vertebral body, increasing the risk of vascular injury. Those difficulties have led us to abandon lumbotomies to treat L4-L5 ISPL to favour a pure anterior approach (midline) or an exclusive posterior approach. LEVEL OF EVIDENCE: IV (retrospective study).

Initial disc structural preservation in type A1 and A3 thoracolumbar fractures.

PURPOSE: Despite a sizable amount of literature, the optimal management of thoracolumbar fractures remains controversial and many authors assume the existence of disc lesions in Magerl type A fractures. The purpose of the study was to assess the intervertebral discs in these fractures at the time of trauma. The hypothesis was that there was no change in shape and signal intensity of the discs initially. METHODS: Fifty-one patients diagnosed with 87 types A1 and A3 thoracolumbar fractures were enrolled in a prospective study. MRI analysis involved evaluation of disc signal, height and morphological modifications according to Oner's classification. RESULTS: No signal intensity modification was identified on MRI. Disc morphology was either normal or altered with creeping of discal tissue in the vertebral endplate depression. Overall, 98% of the discs were either type 1 or type 3. Mean disc height on MRI was 1.03 ± 0.36 initially. CONCLUSIONS: In this study, MRI showed that no loss of height occurred in discs adjacent to fractured vertebra and that there was no major alteration of the disc in terms of signal intensity and morphology. Therefore, the intervertebral disc should not be removed in Magerl type A fractures. LEVEL OF EVIDENCE: Level IV, therapeutic case series.

Bartonella henselae osteoarthritis of the upper cervical spine in a 14-year-old boy.

We report a case of Bartonella henselae, an agent of cat scratch disease, C1-C2 osteoarthritis with osteolysis of the lateral mass of C2 in a 14-year-old boy. Oral antibiotics did not successfully treat the infection and surgery was necessary to treat the septic arthritis. The case opens discussion about bacterial osteoarthritis of the cervical spine and bone involvement in disseminated bartonellosis.

Laparoscopic treatment of incisional hernia. State of the art in 2012.

OBJECTIVE: The objective of this review is to evaluate the results of laparoscopic treatment of ventral hernias using intra-peritoneal prosthetic mesh through a review of published surgical series. METHODS: All large series of patients treated for an incisional hernia by laparoscopy and published between 2002 and 2011 were identified. The results of controlled randomized series comparing this technique with open surgical repair were analyzed. RESULTS: Twenty-two series with a total of 7057 patients were analyzed (range 51-1242); the mean Body Mass Index (BMI) was 32 (range: 28.5-46), and the mean size of the hernia defect was 10.6 cm (range: 6-14.9 cm). The mean rate of conversion to open surgical repair was 2.7%. Mean operative duration was 90 ± 33 minutes. Mortality was 0.8%, usually due to an unrecognized intestinal injury (1.6%), which occurred more frequently with second or iterative hernia repairs. Hospital stay averaged 2.5 days. The infection rate was 0.3% and the rate of hernia recurrence was 4.6% (with a mean follow-up of 36 months). No statistically significant differences were found in terms of post-operative complications or hernia recurrence in the randomized studies comparing laparoscopic to open anterior abdominal surgical repair. However, duration of hospital stay was shorter after laparoscopy in some studies. CONCLUSION: Laparoscopic repair of ventral incisional hernia is technically feasible and reliable for large hernia defects, even in obese patients. This approach should be reserved for patients with no history of previous hernia repair in order to avoid the risk of intestinal injury. It appears to allow for a shortened duration of hospitalization.

Traumatic atlantoaxial dislocation with odontoid fracture: A case report.

We are reporting the one-year follow-up for a case of traumatic atlantoaxial dislocation associated with an odontoid fracture. This injury combination is rare and serious because of its resulting instability. After an unsuccessful attempt at closed reduction with traction, an open reduction with occipitocervical fixation was performed using a posterior approach. Based on our experience and a review of the published literature, the method for managing such an injury is discussed. If closed reduction with traction is successful, subsequent treatment is based on the algorithms for isolated odontoid fractures. If the closed reduction fails, surgical treatment consists of an open reduction using a posterior or lateral retropharyngeal approach, and then fixation of C1-C2, which is the key procedure.

Computed tomographic study of the posterior condylar angle in arthritic knees: its use in the rotational positioning of the femoral implant of total knee prostheses.

The epicondylar axis is a reliable reference to check the rotation of the femoral implant in total knee prostheses (TKPs). However, during the operation it seems easier to use the posterior condylar axis as a landmark. The angle between these two axes is called the posterior condylar angle (PCA). The aim of this study was to measure the PCA in arthritic knees to assess the reliability of the posterior condylar axis as a reference for the control of the rotation of the femoral implant and to look for correlation with other radiological measurements. This prospective study consisted of 103 arthritic knees (81 varus, 22 valgus) before a TKP had been done in 103 patients (75 women, 28 men). The assessment of the PCA was made by computed tomographic scanning (CT). The HKA, HKS and HKT angles were measured on the pangonogram. The posterior condylar axis was internally rotated with respect to the epicondylar axis. The average value for all the patients was 2.65 degrees degrees with a range from 0 degrees to 7 degrees. The PCA was significantly increased in the valgus knees. There was no correlation between the angles on the pangonogram and the posterior condylar axis. While the preoperative assessment of the PCA by CT scanning is reliable, the results obtained indicate the marked variability in its value. If one wishes to use the posterior condylar axis as a guide for rotation, it is therefore necessary to assess the PCA for each patient using adjustable jigs according to the value obtained. No measurement on standard radiographs allowed an extrapolation of the value of the PCA, and CT scanning seems to be the preferable radiological examination.

Recurrent hemarthrosis following total knee arthroplasty. Report of a case treated with arterial embolization.

Recurrent spontaneous hemarthrosis of the knee is common and often related to a detectable cause. In contrast, hemarthrosis after knee arthroplasty is rare and frequently unexplained. We report a case of recurrent hemarthrosis 6 years after total knee arthroplasty. The cause was hypervascularization about the joint, and embolization therapy was effective.

[Bone reconstruction, leg length discrepancy, and dislocation rate in 52 Wagner revision total hip arthroplasties at 44-month follow-up]. / Reconstruction osseuse, inégalité de longueur des membres, taux de luxation de 52 prothèses de Wagner, en révision d'arthroplasties totales de hanche au recul moyen de 44 mois.

PURPOSE OF THE STUDY: The primary and secondary stability of a revision implant is highly compromised in cases with important loss of bone stock from the proximal femoral after severe femoral loosening. Several methods using implants with or without cement have been proposed for reconstruction after femoral bone loss. The purpose of this study was to analyze mid-term clinical and radiological outcome with the Wagner prosthesis for revision surgery. MATERIAL AND METHODS: Fifty-two cases of aseptic femoral loosening were treated with this method in 36 women and 14 men, mean age 70 years (range 32-92 years). None of the patients was lost to follow-up; five who died after 18 months were retained for analysis. Mean follow-up was 44 months (range 18-88 months). The mean preoperative Postel Merle d'Aubigné (PMA) score was 10.5 +/- 0.4. These patients had major bone loss (5 grade II, 24 grade III, 23 grade IV in the SOFCOT classification). The transfemoral access was used in 17 cases and bone grafts in 32. Clinical outcome was assessed with the PMA score and leg length discrepancy was measured. Radiographically, stability was assessed by measuring stem impaction and progression of radiolucent lines. RESULTS: The overall functional score was significantly improved from 10.5 +/- 0.4 preoperatively to 14.6 +/- 0.5 (p<0.001). All items on the score improved but pain relief was the most notable. Improvement in the gait score was limited due to persistent limping in 39 patients. Leg length discrepancies were found in 8 patients with 6 shortenings and 2 lengthenings. The clinical situation remained stable after one year. The implant remained stable in 48 patients (92 p. 100) and stem impaction was observed in 4 before 12 months. Two of these cases required a second revision. Metaphyseal reconstruction was observed in 42 patients (81 p. 100), including 24 (46 p. 100) who exhibited homogeneous reconstruction with trabeculation. The reconstruction did not progress further after 18 months postoperatively. Complications included four dislocations and five revision procedures (three for cup loosening, two for femoral pivot instability). DISCUSSION: The functional outcome was similar to results reported in the literature, including the high frequency of limping that was caused by various factors (valgus prosthesis neck, leg length discrepancy, muscle deficits). Leg length discrepancies resulted from defective positioning or impaction at loading. Standard radiographic series allowed an assessment of stem impaction. Our low rate could be due to delayed weight bearing. La reconstruction of bone loss did not progress after 18 months and was independent of bone grafting, route of access, and the initial degree of loosening. The high frequency of dislocations with this type of implant can be prevented by horizontalization of the acetabulum and use of anti-dislocation inserts at the first intention revision. CONCLUSION: Our results with the Wagner prosthesis are satisfactory both clinically and radiographically. The two drawbacks of this implant (limping and dislocation), partly due to the design of the femoral stem, have led us to study a new implant that preserves good distal anchoring and optimizes the proximal biomechanics of the hip joint.

Transformation of rat embryo fibroblasts by cloned polyoma virus DNA fragments containing only part of the early region.

Recombinant plasmids containing either the entire polyoma viral genome or one or the other of the two HindIII fragments of polyoma virus DNA were constructed and cloned in Escherichia coli X1776, and their DNAs were individually tested for the capacity to transform an established line of rat cells. The recombinant plasmids containing the entire polyoma genome and those containing the HindIII-1 fragment of polyoma DNA (45-1.4 map units) efficiently transform rat cells, whereas the plasmids containing the HindIII-2 fragment (1.4-45.0 map units) do not. The properties of many independent transformed cell lines established by infection with the cloned HindIII-1 fragment were determined. In contrast to the parent cell line, rat cells transformed with the cloned HindIII-1 fragment grow to high saturation densities, form colonies with high efficiency in dilute agar suspension, produce high levels of plasminogen activator, and display a disorganized arrangement of actin cables. By all criteria examined, these cells transformed by fragments are indistinguishable from cells transformed by whole polyoma viral DNA. Cellular DNA prepared from many HindIII-1 fragment-transformed cell lines was analyzed for the presence and arrangement of polyoma viral sequences by Southern blot-hybridization. In all cases examined, only those viral sequences contained within the HindIII-1 fragment of polyoma DNA were detected. These data establish a strong correlation between polyoma DNA sequences mapping within a restricted portion of the early region and the induction and maintenance of the transformed phenotype.