Real-world outcomes of two different sensor-augmented insulin pumps with predictive low glucose suspend function in type 1 diabetes patients.

AIM: To analyse the real-life outcomes of two sensor-augmented pumps (SAP) with predictive low glucose suspend (PLGS) function, Medtronic Minimed 640G™ with SmartGuard (MM640G) and Tandem T Slim X2™ with Basal-IQ™ (TTSX2), in Type 1 Diabetes Mellitus (T1DM) patients. METHODS: Observational cross-sectional study using data obtained from computerized clinical records. All T1DM patients on TTSX2 therapy were compared (1:1) with MM640G treated patients selected through stratified sampling. Primary efficacy outcome was to describe time in rage (TIR, 70-180 mg/dL, 3.9-10 mmol/L) interstitial glucose differences according to a non-inferiority hypothesis with TTSX2 compared to MM640G. RESULTS: Forty-four patients were analyzed (female 66%). Mean age was 38.9 yrs. (range 23-59 yrs.) and mean diabetes duration was 23.4 ± 9.2 yrs. Patients treated with TTSX2 showed a numerically slightly lower, but non-statistically significantly different, TIR from the MM640G pump group (64.9 ± 16.4% vs. 72.4 ± 17.0%, P = 0.108). Similarly, we did no find differences in HbA1c between T1D patients treated with TTSX2 and MM640G (6.8 ± 1.0% vs. 7.0 ± 0.9%, 51 ± 11 mmol/mol vs. 53 ± 10 mmol/mol, P = 0.312). Moreover, rest of evaluated glycemic outcomes were similar between both treatment groups. CONCLUSIONS: Patients using two different SAP with PLGS automatic function showed similar glycaemic control in a real-world scenario. NCT04741685.

[Comparative clinical study of 2 surgical techniques for trapeziometacarpal osteoarthritis]. / Estudio clínico comparativo de 2 técnicas quirúrgicas de rizartrosis del pulgar.

OBJECTIVE: In trapeziometacarpal osteoarthritis (or rhizarthrosis), there is great controversy over the surgical technique to choose: simple trapeziectomy, resection-interposition arthroplasty, interposition arthroplasty suspension-or arthroplasty with implant or prosthesis. These latter 2 are the most used without consensus in the literature on the technique to choose and without sufficient comparative studies. The objective is to compare the 2 techniques most used today: suspension-interposition arthroplasty and arthroplasty with prosthesis. MATERIAL AND METHOD: A prospective study was conducted on 15 patients diagnosed with grade 2-3 rhizarthrosis treated with interposition arthroplasty-suspension (group 1) and 15 with prosthesis (group 2) showing clinical outcomes, advantages and disadvantages of each. The study variables were the visual analogue scale (VAS), the DASH questionnaire, the grip strength, the strength of end to end and end-lateral clamp, the joint balance adduction-abduction and preemption-retropositioning, and the opposition. The 2 groups are from 2 different hospitals operated on by a hand surgeon from the Hand Unit. The follow-up time for all patients included in the study was 12 months. RESULTS: The VAS, DASH and grip strength at 12 months did not show significant differences. As regards the strength of end to end and end-lateral clamp, group 2 showed the highest values in all follow-up periods with statistically significant differences. CONCLUSIONS: Patient selection and surgical experience is essential, given the satisfactory results of both techniques. Arthroplasty prosthesis is reserved for grades 2 and 3, middle-aged patients, good trapezium architecture, and experienced surgeons.

Tratamiento de la sinostosis radiocubital proximal mediante la interposición de colgajo interóseo posterior de flujo anterógrado / Treatment of proximal radioulnar synostosis using a posterior interosseous antegrade flow pedicled flap

Nuestro objetivo es estudiar las diferentes opciones terapéuticas descritas para el tratamiento de la sinostosis radiocubital y, aportar nuestra experiencia con las modificaciones técnicas introducidas con posterioridad. Hemos revisado 2 pacientes con más de un año de evolución, que fueron operados con el colgajo reseñado; describimos las novedades técnicas, el resultado final y las complicaciones. En los 2 casos descritos existe ausencia de recidiva de sinostosis, complicación más frecuente descrita en esta enfermedad, con ausencia de complicaciones postoperatorias. En la literatura se han empleado numerosos materiales interpuestos en el espacio radiocubital tras la exéresis de la sinostosis, desde artificiales hasta biológicos libres o vascularizados; siendo la técnica de interposición de colgajos musculares o adipofascial vascularizados, la que ofrece los mejores resultados. El colgajo interóseo posterior pediculado de flujo anterógrado es una alternativa fiable, de poca morbilidad y, efectiva para el tratamiento de la sinostosis radiocubital proximal (AU)

The aim of this study is to determine the different therapeutic options described for the treatment of radioulnar synostosis, and report our experience with posterior interosseous antegrade flow pedicled flap with technical amendments. Two patients, who were treated with the designed flap, and with more than one year of follow-up, were reviewed. The technical innovations, end result and complications are described. In the two cases described, there was no recurrence of synostosis, which is the most frequent complication described in this condition, and no postoperative complications were observed. In the literature, many filler materials, from artificial to biological, free or vascularized, have been used the radioulnar space after excision of synostosis. The technique that provides the best results is the interposition of muscle or vascularized adipofascial flaps. The interosseous posterior antegrade flow pedicled flap is reliable, with a low morbidity, and is an effective alternative for the treatment of proximal radioulnar synostosis (AU)

[Treatment of proximal radioulnar synostosis using a posterior interosseous antegrade flow pedicled flap]. / Tratamiento de la sinostosis radiocubital proximal mediante la interposición de colgajo interóseo posterior de flujo anterógrado.

The aim of this study is to determine the different therapeutic options described for the treatment of radioulnar synostosis, and report our experience with posterior interosseous antegrade flow pedicled flap with technical amendments. Two patients, who were treated with the designed flap, and with more than one year of follow-up, were reviewed. The technical innovations, end result and complications are described. In the two cases described, there was no recurrence of synostosis, which is the most frequent complication described in this condition, and no postoperative complications were observed. In the literature, many filler materials, from artificial to biological free or vascularized, have been used the radioulnar space after excision of synostosis. The technique that provides the best results is the interposition of muscle or vascularized adipofascial flaps. The Interosseous posterior antegrade flow pedicled flap is reliable, with a low morbidity, and is an effective alternative for the treatment of proximal radioulnar synostosis.

La carpeta de aprendizaje: una innovación docente en la asignatura de Radiología y Medicina Física Especial / The portfolio: an innovate educational project on the subject of Radiology and Special Physical Medicine

Objetivo. Presentar una innovación docente desarrollada en la asignatura de Radiología y Medicina Física Especial durante el curso académico 2006-2007. Sujetos y métodos. Los alumnos realizaron una rotación durante dos semanas en los servicios de Radiodiagnóstico y Medicina Nuclear, en grupos pequeños. La metodología docente utilizada fue la carpeta de aprendizaje o portafolio. Se describen los aspectos fundamentales para la elaboración de la carpeta y de los casos clínicos, así como del sistema de evaluación. Dentro del ciclo de mejora continuada se llevó a cabo una encuesta de satisfacción. Resultados. Los resultados académicos obtenidos fueron excelentes. La mayoría de los alumnos consideraron que la asignatura fue interesante. También señalaron una valoración positiva de la rotación, de los seminarios y del sistema de evaluación. Asimismo, la opinión de los alumnos acerca de la experiencia docente realizada fue muy favorable. Conclusión. La satisfacción global de los alumnos ha sido muy alta con la metodología docente implantada en la asignatura (AU)

Aim. To introduce a learning innovation on the subject of Radiology and Special Physical Medicine along the academic year 2006/2007. Subjects and methods. Working in small groups, students carried out a two-week rotation in the departments of Radiology and Nuclear Medicine. The portfolio was the educational methodology used. The main aspects to elaborate the portfolio, the case reports, aswell as the evaluation system are described. A satisfaction survey within the continuous improvement course was performed. Results. The academic results achieved were excellent. The subject was considered interesting by most of the students. A positive evaluation about the rotation made by the students, the seminaries and the evaluation system was made. Students’ opinion about the educational experience performed was also, very favourable. Conclusion. The educational methodology introduced in the subject has produced a high level of satisfaction among the students (AU)

Pancreatitis por hiperparatiroidismo primario durante el embarazo / Pancreatitis and primary hyperparathyroidism during pregnancy

El hiperparatiroidismo primario (HPP) durante el embarazo puede llevar a graves complicaciones fetales y maternas, como la pancreatitis agua. Por ello, el tratamiento médico sólo se considera en gestantes asintomáticas con calcemias moderadas, y en el resto se opta por el abordaje quirúrgico. Presentamos a una gestante de 9 semanas con hiperemesis gravídica y pancreatitis aguda por hipercalcemia secundaria a un adenoma paratiroideo. La falta de respuesta al tratamiento médico conservador llevó a la intervención en el segundo trimestre de embarazo. La cirugía resultó exitosa, y la gestación, el parto y el recién nacido no presentaron más incidencias. Concluimos que la cirugía en el segundo trimestre de embarazo es una alternativa eficaz en el tratamiento del HPP cuando fracasa el abordaje conservador

Primary hyperparathyroidism (PHP) during pregnancy could conduce to seriously fetal and maternal complications as acute pancreatitis. Because of that, medical treatment can be consider only in asymptomatic pregnants with moderate calcium levels, in the rest of cases is prefer to use surgical management. We present a 9th week pregnant with hyperemesis gravidarum and acute pancreatitis due to hypercalcemia secondary to a parathyroid adenoma. The absence of response to medical treatment conduced to surgical intervention during second trimester of pregnancy. Surgery was successful, and not any incidence was detected in the rest of gestation, delivery and newborn. We conclude that surgery during second trimester is an efficacy alternative in HPP treatment when conserver management failed