Twelve-month follow-up of family communication and psychopathology in children and adolescents with a first psychotic episode (CAFEPS study).

We analyzed the potential influence of family relationships and history of psychiatric disorders on the presentation and course of early psychotic disorders. We recruited 110 subjects aged 9-17 years with a first psychotic episode and 98 matched healthy controls, and followed them for 1 year. Data were collected through clinical interviews and the Parent-Adolescent Communication Inventory. A family history of psychosis-related disorders was more common in patients' families, with a five-fold higher risk for psychoses related disorders than families of healthy controls. If we consider psychoses related disorder in first-degree relatives, the risk is even higher, rising to 15-fold. The families of patients with a first psychotic episode score themselves worse in communication than the families of healthy controls. More problems in communication at baseline correlated with a higher degree of psychopathology and a lower clinical improvement after 12 months of follow-up.

Obstetric complications as a risk factor for first psychotic episodes in childhood and adolescence.

There are reports of significant association between obstetric complications (OC) and childhood psychosis. Authors conducted a case-control study of 102 children and adolescents with a first episode psychosis (FEP) and 94 healthy controls (HC), using the obstetric complications scale (OCS) and their medical records, to examine the risk of FPE. Patients were recruited from child and adolescent psychiatry units at six university hospitals and controls from publicly-funded schools of similar characteristics and from the same geographic areas. A logistic regression was performed to quantify the risk of psychosis in childhood and adolescence, based on OC, adjusting for potential confounding factors like socio economic status (SES) and family psychiatric history (FPH). OC appeared more frequently in the records of patients. Significant differences between patients and controls were found in Prenatal OC (15.7% vs. 5.3%, P < 0.05) and among them, bleeding in pregnancy showed the greatest difference between groups (12.7% vs. 2.1%, P < 0.01). In the logistic regression, bleeding in pregnancy showed a crude odds ratio (OR) of 6.7 (95%CI = 1.4-30.6) and 5.1 (CI 95% = 1.0-24.9) adjusted for SES and FPH. Therefore, bleeding in pregnancy is a likely risk factor for early-onset psychosis.

Suggestion overrides the Stroop effect in highly hypnotizable individuals.

Cognitive scientists distinguish between automatic and controlled mental processes. Automatic processes are either innately involuntary or become automatized through extensive practice. For example, reading words is a purportedly automatic process for proficient readers and the Stroop effect is consequently considered the "gold standard" of automated performance. Although the question of whether it is possible to regain control over an automatic process is mostly unasked, we provide compelling data showing that posthypnotic suggestion reduced and even removed Stroop interference in highly hypnotizable individuals. Drawing on a large sample of highly hypnotizable participants, we examined the effects of suggestion on Stroop performance both with and without a posthypnotic suggestion to perceive the input stream as meaningless symbols. We show that suggestion administered to highly hypnotizable persons significantly reduced Stroop interference and derailed a seemingly automatic process.

Cortical blood flow during rest and Wisconsin Card Sorting Test performance in schizophrenia.

BACKGROUND: The aim of this study is to examine if patients with schizophrenia differ in prefrontal, orbitofrontal, temporal, parietal and occipital blood flow from healthy controls during performance of the Wisconsin Card Sorting Test (WCST). METHODS: We conducted a 99mTc-hexamethylpropylene amine oxime-SPECT study in patients with schizophrenia (n = 21) and in healthy controls (n = 18). The assessment of relative regional cerebral blood flow (relCBF) was achieved by comparing blood flow of well-defined cortical regions to whole brain blood flow. relCBF at rest and during WCST was compared between the groups and in the groups. RESULTS: Significant bilateral prefrontal and right-sided parietal increases of relCBF were found in patients (p < 0.05) during resting conditions, while prefrontal and parietal interhemispheric asymetry were higher in patients (p < 0.005). However, patients failed to increase right prefrontal and frontobasal relCBF as well as orbitofrontal interhemispheric asymetry during WCST performance in contrast to the control group (p < 0.05). The right occipital relCBF increased significantly in patients only (p < 0.05). CONCLUSIONS: In our study we could confirm the common hypothesis of schizophrenic hypofrontality at rest and during WCST performance. Moreover, due to our method, we identified significant frontal and parietal interhemispheric asymmetries in schizophrenia at rest as well as right occipital hyperperfusion during WCST.