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Org Lett
; 25(23): 4308-4312, 2023 06 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37278485
RESUMO
Erdafitinib, an anticancer drug, was synthesized in a three-step two-pot sequence involving ppm levels of Pd catalyst run under aqueous micellar conditions enabled by a biodegradable surfactant. This process features both pot- and time-economies and eliminates egregious organic solvents and toxic reagents associated with existing routes.