Hyperglycemia in extremely low birth weight infants in a predominantly Hispanic population and related morbidities.

OBJECTIVE: This study describes the incidence, correlates and subsequent morbidities of hyperglycemia, a highly prevalent condition in extremely low birth weight (ELBW) infants. STUDY DESIGN: A retrospective chart review of 169 infants with birth weight (BW)<1000 g was conducted. Hyperglycemia was defined as plasma glucose level > or =150 mg/dl during the first 2 weeks of life. Data were analyzed by logistic regression, multivariate analysis and Fisher exact test. RESULTS: Overall, 88% of the study sample developed hyperglycemia in the first 2 weeks of life. Both gestational age (GA) (odds ratio (OR) 0.11, 95% confidence interval (CI)=0.01-0.89) and chorioamnionitis (OR 0.10, 95% CI=0.01-0.64) were inversely associated with hyperglycemia, whereas BW, sepsis and postnatal steroid exposure were not. After adjusting for GA, BW and postnatal steroids, hyperglycemia was associated with a statistically significant increase in retinopathy of prematurity (ROP) (OR 4.6, 95% CI 1.12-18.9). No association was found with bronchopulmonary dysplasia, intraventricular hemorrhage, death or prolonged hospital stay. CONCLUSION: Lower GA was identified as the main factor associated with hyperglycemia in ELBW infants during the first 2 weeks of life. Hyperglycemia was associated with an increased incidence of ROP; further studies need to determine if this association is causal.

Effect of chlortetracycline in a trace mineral salt mix on fertility traits in beef cattle females in Florida.

The study objective was to determine the effect of chlortetracycline in an ad libitum trace-mineralized salt mix given to heifers before and(or) during bull exposure on the proportion pregnant and the time to conception in a fixed breeding period. Heifers (n = 768), 13 to 15 mo of age, were individually identified, immunized (Leptospira, Campylobacter fetus), examined (body condition score, vaginal lesion score, BW), and randomly allocated within 2 x 2 factorial blocks of treatments where trace mineral salt with and without chlortetracycline medication was provided in similar but nonadjacent pastures either before and(or) during bull exposure. The chlortetracycline feeding period was about 30 d for each. In the 2 d immediately before bull exposure, heifers were examined (body condition score, vaginal lesion score, reproductive tract evaluation) and reallocated to treatment pastures. Pregnancy was determined by per rectal palpation at 45 d following bull removal. Mineral intake was below that expected for heifer groups and, as a result, chlortetracycline intake was estimated at less than one-third of that targeted. Many heifers were not cycling reproductively at the onset of bull exposure (n = 456, 60.3%, based on a reproductive tract score < 3). Despite these limitations, heifers receiving chlortetracycline treatment before breeding had a pregnancy percentage of 65% (chlortetracycline before and during breeding 67% and chlortetracycline before breeding 61.8%) compared to those receiving no treatment before breeding (53%, P < 0.03; no chlortetracycline before or during breeding 60.4% and chlortetracycline during breeding 47.4%). Heifers receiving chlortetracycline treatment before breeding were 57% more likely to become pregnant than those not treated before breeding. Change in vaginal lesion score was associated with the proportion pregnant, but neither body condition score nor average daily gain were.

State-level treatment outcome studies using administrative databases.

State substance dependence administrative databases contain both administrative and clinical information on large numbers of patients collected over extended time periods. Access to other state databases--employment, criminal behavior, and Medicaid--has also been achieved in some instances. Such data could prove an important source for the evaluation of long-term treatment outcomes and their determinants. This selected review describes and evaluates the treatment outcome and cost-related findings of the most advanced studies using these databases. A number of these studies have shown that completion of substance dependence treatment is associated with reduced societal costs. Some of these studies have focused on significant subpopulations of patients, including pregnant women and adolescents. A shortcoming of the findings of most of these studies concerns their use of noncompleter or non-randomly collected comparison groups. The utility of these databases can be enhanced by coupling them with clinical research treatment outcome evaluation approaches.

School expulsion as a process and an event: before and after effects on children at risk for school discipline.

A better understanding of expulsion as an act, a process, and an educational intervention leads to an entirely different understanding of student behavior and disciplinary consequences.

Extensible, Low-Chromatic-Sensitivity, All-diffractive-Optics Relay for Interconnecting Optoelectronic Device Arrays.

For free-space optical interconnections between optoelectronic chips to reach commercial realization, the technology must provide high-density optical channels in a simple, inexpensive, and easily aligned package. Although point-to-point connections with microlens pairs can provide densities of several thousand channels per square centimeter, the Gaussian nature of the beams limits the connection range to a few millimeters. We propose an arrangement of microlens pairs with an intermediate relay lens that significantly increases the connection distance. This basic setup can be tiled laterally across large chips to form extensible arrays. The optical design is constructed entirely with diffractive elements because of the low chromatic sensitivity over a range of approximately ?10% around the design wavelength. We derive the lateral positioning error at the image by using a simple ray trace, and we show the effect of Gaussian beams. We experimentally demonstrate the low chromatic sensitivity for a system with an interconnection distance of 64 mm. Finally, we demonstrate the interconnection of two linear arrays of multimode fibers with two adjacent channels operating at data rates of hundreds of megabits per second.

Asynchronous transfer mode distribution network by use of an optoelectronic VLSI switching chip.

We describe a new optoelectronic switching system demonstration that implements part of the distribution fabric for a large asynchronous transfer mode (ATM) switch. The system uses a single optoelectronic VLSI modulator-based switching chip with more than 4000 optical input-outputs. The optical system images the input fibers from a two-dimensional fiber bundle onto this chip. A new optomechanical design allows the system to be mounted in a standard electronic equipment frame. A large section of the switch was operated as a 208-Mbits/s time-multiplexed space switch, which can serve as part of an ATM switch by use of an appropriate out-of-band controller. A larger section with 896 input light beams and 256 output beams was operated at 160 Mbits/s as a slowly reconfigurable space switch.

Design and demonstration of a high-speed, multichannel, optical-sampling oscilloscope.

Free-space digital optical systems have demonstrated the capability to provide thousands of optical connections between optoelectronic chips. This dense concentration of channels creates substantial challenges in monitoring individual connections for diagnostic purposes without compromising performance. Prom the concept of stroboscopic techniques, we have designed and constructed a multichannel optical diagnostic tool that operates analogously to an electronic-sampling oscilloscope. The tool is economically constructed by the use of commercially available video cameras and video-enhanced personal computers. An integrated software application operates the tool and displays multiple-channel waveforms. We demonstrate the oscilloscope-sampling optical waveforms of a two-dimensional optoelectronic modulator array operating at data rates from 0.5 to 4 Gbits/s.

Family interactions of schizophrenic and schizoaffective patients: determinants of relatives' negativity.

Videotaped family problem-solving interactions of 57 schizophrenic or schizoaffective patients and their relatives were examined for predictors of negativity of their communication behavior. Ratings of patients' behaviors and independent assessments of patients' symptomatology were used to predict the negativity of relatives in the videotaped interaction. The results indicated that severity of symptomatology was not related to relatives' negativity. Patients' social skill, as independently assessed by a role-play test, also was not associated with relatives' negativity. The regression results suggest that with both members of a patient-relative dyad, the quality of communication in a discussion is related to the other participant's level of negativity.

A transmission electron microscopic (TEM) method for determining structural colors reflected by lizard iridophores.

Iridescent tissue colors are thought to be produced by iridophores through the optical phenomenon of thin-layer interference. Land and others have shown that structural features, predominantly reflecting platelet width and the cytoplasmic spacing between layers of platelets, determine the wavelength of light maximally reflected by this mechanism in iridophores. Some researchers have used interference microscopy to estimate these structural parameters, but the most direct measurement technique should be transmission electron microscopy (TEM). Transmission electron microscopy (TEM) has associated processing artifacts (particularly cytoplasmic shrinkage) that preclude direct measurement of ultrastructure, but if a number of assumptions are made, reflected wavelengths can be predicted. A thin-layer interference model and its associated assumptions were tested using TEM measurements of iridophores from several brightly colored tissues of each of three lizards (Sceloporus jarrovi, S. undulatus erythrocheilus, and S. magister). In all the instances examined when the contribution of the pigments present were accounted for, tissue color corresponded with predicted iridophore reflectances from the model. Finally, if the model and its assumptions are assumed to be correct, the amount of iridophore cytoplasmic shrinkage as a result of TEM processing can be calculated.

Time-domain images.

We demonstrate that, using a hologram, we can convert a spatial x-y image into an x-t image, where one spatial dimension is now transformed into the time domain. In particular, we generate the temporal equivalent of our corporate logo, where every pixel of the image is now represented by a short optical pulse.

Shuffle-equivalent interconnection topologies based on computer-generated binary-phase gratings.

Several different shuffle-equivalent interconnection topologies that can be used within the optical link stages of photonic-switching networks are studied. These schemes include the two shuffle, the two banyan, and the segmented two shuffle, which can be used to interconnect two-input, two-output switching nodes. The schemes also include the four shuffle and the four banyan, which can be used to interconnect four-input, four-output switching nodes. (Note: The segmented two shuffle and the four banyan are novel interconnection topologies that were developed to satisfy some of the constraints of free-space digital optics). It is shown that each of these interconnection topologies can be implemented by the use of relatively simple imaging optics that contain space-invariant computer-generated binaryphase gratings. The effects of node type and interconnection topology on the laser power requirements and the optical component complexity within the resulting systems are also studied. The general class of networks nown as extended generalized shuffle networks is used as a baseline for the analysis. It is shown that (2, 1, 1) nodes and (2, 2, 2) nodes connected by two-banyan interconnections can produce power-efficient and cost-effective systems. The results should help identify the architectural trade-offs that exist when a node type and an interconnection topology are selected for implementation within a switching system based on free-space digital optics.

Five-stage free-space optical switching network with field-effect transistor self-electro-optic-effect-device smart-pixel arrays.

The design, construction, and operational testing of a five-stage, fully interconnected 32 × 16 switching fabric by the use of smart-pixel (2, 1, 1) switching nodes are described. The arrays of switching nodes use monolithically integrated GaAs field-effect transistors, multiple-quantum-well p-i-n detectors, and self-electro-optic-device modulators. Each switching node incorporates 25 field-effect transistors and 17 p-i-n diodes to realize two differential optical receivers, the 2 × 1 node switching logic, a single-bit node control memory, and one differential optical transmitter. The five stages of node arrays are interconnected to form a two-dimensional banyan network by the use of Fourier-plane computer-generated holograms. System input and output are made by two-dimensional fiber-bundle matrices, and the system optical hardware design incorporates frequency-stabilized lasers, pupil-division beam combination, and a hybrid micro-macro lens for fiber-bundle imaging. Optomechanical packaging of the system ut lizes modular kinematic component positioning and active thermal control to enable simple rapid assembly. Two preliminary operational experiments are completed. In the first experiment, five stages are operated at 50 Mbits/s with 15 active inputs and outputs. The second experiment attempts to operate two stages of second-generation node arrays at 155 Mbits/s, with eight of the 15 active nodes functioning correctly along the straight switch-routing paths.

Beam array generation and holographic interconnections in a free-space optical switching network.

Free-space photonic switching systems that optically interconnect large arrays of simple processing elements have already been demonstrated [IEEE Photon. Technol. Lett. 2, 438,600 (1990); Appl. Opt. 31, 5431 (1992); Electron. Lett. 27, 1869 (1991)]. In these system experiments, diffractive optical elements served as critical components that provided functionality not easily assumed by conventional optics. In the latest optical switching network, binary phase gratings were used to generate arrays of uniformintensity beams to illuminate modulators in the processor array. In addition, space-invariant binary phase grating designs were integral in forming the Banyan interconnection network used to link arrays in the system. Here we discuss the function, design, and performance of these diffractive elements.

Six-stage digital free-space optical switching network using symmetric self-electro-optic-effect devices.

We describe the design and demonstration of an extended generalized shuffle interconnection network, centrally controlled by a personal computer. A banyan interconnection pattern is implemented by use of computer-generated Fourier holograms and custom metallization at each 32 × 32 switching node array. Each array of electrically controlled tristate symmetric self-electro-optic-effect devices has 10,240 optical pinouts and 32 electrical pinouts, and the six-stage system occupies a 9 in. × 12.5 in. (22.9 cm × 31.7 cm) area. Details of the architecture, optical and mechanical design, and system alignment and tolerancing are presented.

The ability of schizophrenics to perceive and cope with negative affect.

Thirty-four schizophrenic patients in an acute in-patient hospital were compared with 24 in-patients with major affective disorder and 19 non-patient controls on a role-play test of social skills and a test of affect perception. The role-play test consisted of 12 simulated conversations in which the subject was confronted by parents and friends expressing high-EE criticism or non-critical dissatisfaction. Schizophrenic patients lacked assertiveness and social skills in all conditions, but they did not show any differential impairment when presented with high EE. They consistently lied and denied errors rather than responding assertively or apologizing, whether confronted with high-EE or benign criticisms. On the affect perception test, schizophrenic patients consistently underestimated the intensity or negativeness of negative emotions, but they were not deficient in perception of positive emotional displays. The data do not support the hypothesis that schizophrenic patients are poor at dealing with high-EE behaviours, but do indicate that their ability to cope with even mild negative affect is impaired. Possible explanations for this impairment include limited attentional capacity, a neurologically based perceptual deficit, and a self-protective mechanism to reduce or avoid stress.

Experimental investigation of a free-space optical switching network by using symmetric self-electro-optic-effect devices.

A prototype digital free-space photonic switching fabric is demonstrated. It consists of three cascaded 16 x 8 arrays of symmetric self-electro-optic-effect devices that are used as logic gates that implement part of a multistage interconnection network. We discuss architecture, device tolerancing, optical system design, and optomechanical design. This optical circuit is successfully configured as a fully operational array of 32 independent 2 x 2 nodes and operates at 100 kHz.

Pigments and ultrastructures of pigment cells in xanthic sailfin mollies (Poecilia latipinna).

Electron micrographs of skin from xanthic (gold) sailfin mollies revealed numerous xanthophores, as well as scattered melanophores. The melanophores were seen to contain premelanosomes in various stages of development. This is consistent with the fact that xanthic mollies have been shown to be tyrosinase positive. Melanosomes in xanthic mollies appear to develop by one of two pathways: 1) from an endoplasmic reticulum-derived vesicle which develops an internal lamellar framework, and 2) by fusion of multiple Golgi-derived vesicles which lack an internal lamellar framework. Analysis of the pigments in the skin of the xanthic mollies identified four colorless pteridine pigments (xanthopterin, isoxanthopterin, neopterin, and pterin) and a carotenoid with an absorbance spectrum similar to beta-carotene. It appears that, unlike some other poeciliid fishes, sailfin mollies do not use pteridine pigments for orange coloration. Rather, they appear to rely primarily on carotenoids.

Prevalence and stability of social skill deficits in schizophrenia.

The prevalence of social skill deficits in schizophrenia was examined by comparing patients assessed over a 1 year period with a group of non-patient controls recruited from the community. Social skills were assessed using a role play test and were considered deficient when they were below the range of the control sample. Approximately 50% of the patients were consistently unskilled over the one year, whereas 11% were consistently skilled. Deficits in specific social skills were relative rare. Consistent deficits were present for only one of six specific skills: 14% of the patients were consistently less appropriate in their conversational turn-taking (Meshing) than the controls. Patients' social skills were relatively stable over time. The implications of these results for the assessment and remediation of social skill impairments in schizophrenia are discussed.

Ultrastructural analysis of iridophore organellogenesis in a lizard, Sceloporus graciosus (Reptilia: Phrynosomatidae).

Transmission electron microscopy (TEM) data from the ultrastructure of lizard skin iridophores (reflective dermal chromatophores) are used to illustrate the organellogenesis of small rectangular reflecting platelets, which are the color-generating components of these cells. During the development of reflecting platelets, crystals are deposited within double-membraned vesicles from electron-dense material located within the vesicles. The crystals are initially small but expanded lengthwise eventually to fill the vesicle that contains them. The inner membrane then tightly surrounds the crystal whereas the outer membrane is much more loosely associated with the inner-membrane-bound crystal. These observations allow discussion of the possible origin of the precursor double-membraned vesicles from endoplasmic reticulum (ER) and Golgi-derived vesicles. A model is proposed that incorporates our findings and other published reports to explain the origin of the precursor double-membraned vesicles via three alternative pathways.