A conjugated polymer-peptide hybrid system for prostate-specific antigen (PSA) detection.

We developed fast and readily applicable microarray chips to detect PSA by designing a novel conjugated polymer (energy donor) and combining it with on-chip peptide synthesis. The selective cleavage of a probing peptide labelled with a dye or a quencher (energy acceptor) produced a fluorescence sensory signal via fluorescent energy resonance transfer (FRET).