1.
Bioorg Med Chem
; 23(11): 2695-8, 2015 Jun 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25684425
RESUMO
A three component one-pot cascade reaction was developed for the synthesis of 1,4,5-trisubstituted γ-lactams. The resulting scaffold can be modified independently at three positions, two of which are conveniently accessed by changing the components of the one-pot reaction. The phases of building block generation, scaffold synthesis and subsequent appendage modification were adapted to library production, which resulted in a screening library of 500 compounds.