RESUMO
There are several studies suggesting the paradoxical simultaneous presence of hypertensive lower oesophageal sphincter and gastroesophageal reflux disease. We present a case of a 22-year-old male patient who was examined in our outpatient clinic with oesophageal food bolus impaction during a meal, severe chest pain and drooling. Manometry revealed a hypertensive lower esophageal sphincter pressure (resting pressure 35 mmHg) and pHmetry revealed a DeMeester score > 14.72 (43.27). Six months after therapy with lansoprazole, manometry revealed a normal lower oesophageal sphincter (resting pressure 14 mmHg) and the DeMeester score was < 14.72 (5.89). The patient is now asymptomatic. This report is the only published case which exhibits the normalization of lower oesophageal pressure 6 months after gastroesophageal reflux disease management with lansoprazole, thus proving and establishing the above ''paradox''.
Assuntos
Esfíncter Esofágico Inferior/fisiopatologia , Refluxo Gastroesofágico/complicações , Refluxo Gastroesofágico/fisiopatologia , 2-Piridinilmetilsulfinilbenzimidazóis/uso terapêutico , Adulto , Angina Pectoris/etiologia , Transtornos de Deglutição/etiologia , Refluxo Gastroesofágico/tratamento farmacológico , Humanos , Lansoprazol , Masculino , Manometria , PressãoRESUMO
Gastrointestinal stromal tumors are currently the object of a great clinical and experimental interest. We are presenting the case of a 69-year-old patient, who was presented with lower gastrointestinal bleeding and dyspeptic symptoms over the last six months. The colonoscopy showed a large tumor of the sigmoid and the gastroscopy a large gastric tumor of the antrum, which were histologically diagnosed as colonic adenocarcinoma and gastric stromal tumor respectively. The patient underwent a sigmoidectomy and a partial gastrectomy. Six months after surgery were the clinical condition, abdominal CT, gastroscopy and colonoscopy without pathological findings. To our best knowledge, this is the second report of a synchronous gastric stromal tumor and a colonic adenocarcinoma in medical literature.
Assuntos
Adenocarcinoma/patologia , Neoplasias do Colo/patologia , Tumores do Estroma Gastrointestinal/patologia , Neoplasias Primárias Múltiplas/patologia , Neoplasias Gástricas/patologia , Idoso , Humanos , MasculinoAssuntos
Hepatopatias/complicações , Dermatopatias/etiologia , Hemocromatose/complicações , Hemocromatose/diagnóstico , Hepatite C/complicações , Hepatite C/diagnóstico , Humanos , Cirrose Hepática Biliar/complicações , Cirrose Hepática Biliar/diagnóstico , Hepatopatias/diagnóstico , Hepatopatias Alcoólicas/complicações , Hepatopatias Alcoólicas/diagnóstico , Dermatopatias/diagnóstico , Dermatopatias/patologiaRESUMO
Gastric adenocarcinoma is currently the 14th cause of death worldwide. Early gastric cancer, defined as cancer not penetrating deeper than the submucosa, is considered to carry an excellent prognosis with 5-year survival rates reaching more than 90%. Cases of bone metastases due to intramucosal gastric cancer are very rarely described. A case of a 70-year old male presenting with confirmed bone metastases 7 years after a curative resection for a mucosal gastric carcinoma is discussed. The patient was investigated with bone marrow biopsy and bone scan and showed no other signs of disease. The clinicopathologic features included poor differentiation, signet ring cells presence, no lymph node involvement and a negative second laparotomy two years after the initial surgery. Studies concerning the presence of residual disease in the form of bone marrow micrometastases are briefly reviewed emphasizing that intramucosal gastric cancer still carries the p sibility for metastasis, many years after a curative resection, mandating long term alertness from the attending physician.
Assuntos
Adenocarcinoma/secundário , Neoplasias Ósseas/secundário , Neoplasias Gástricas/patologia , Adenocarcinoma/diagnóstico , Idoso , Biópsia , Células da Medula Óssea/patologia , Neoplasias Ósseas/diagnóstico , Progressão da Doença , Evolução Fatal , Seguimentos , Humanos , Masculino , Tomografia Computadorizada por Raios XRESUMO
We report a case of a 65-year-old woman who presented with recurrent episodes of severe, postprandial abdominal pain followed by projectile vomiting. Gastroscopy revealed a large polyp in the prepyloric region. During peristalsis, the polyp was repeatedly 'passing' through the pylorus into the duodenal bulb, hence obstructing the lumen. The polyp was eventually removed in a piecemeal fashion. Histopathologic examination revealed an inflammatory fibroid polyp (known also as Vanek's tumour). A brief review on inflammatory fibroid polyps follows.
Assuntos
Dor Abdominal/etiologia , Obstrução da Saída Gástrica/diagnóstico , Pólipos Intestinais/diagnóstico , Neoplasias Gástricas/diagnóstico , Idoso , Duodeno , Feminino , Obstrução da Saída Gástrica/etiologia , Humanos , Pólipos Intestinais/cirurgia , Piloro , Neoplasias Gástricas/cirurgiaRESUMO
Trimethoprim-Sulfomethoxazole (TMP-SMX) related hepatotoxicity and associated severe systemic reaction are not frequent and documented only in case reports. We report a case of a 30-year-old man, who underwent a 15-day therapy with TMP-SMX for urinary tract infection and two weeks later developed acute cholestatic hepatitis, fever and a skin rash followed by severe systemic reaction. He was admitted in Intensive Care unit and with supportive therapy and prednisolone administration, he showed subsequent improvement over a period of few days. He had fully recovered months later. All tests for other causes of liver disease were negative and his liver biopsy showed evidence of drug-induced hepatic injury.
