[The chemotherapeutic efficacy of ciprofloxacin and lomefloxacin in the inhalation method of infecting white mice with tularemia]. / Khimioterapevticheskaia éffektivnost' tsiprofloksatsina i lomefloksatsina pri ingaliatsionnom sposobe zarazheniia tuliaremiei belykh myshei.

Peculiarities of the protective effect of ciprofloxacin and lomefloxacin were studied and the optimal regimens of their use were determined in multifactor experiments on albino mice infected with finally dispersed aerosol of the virulent strain of the European subspecies of Francisella tularensis. As for protective effect, the fluoroquinolones provided high percentage of the animal survival. The optimal course of the treatment was at least 7 days. The interval of 0 to 48 hours between the infection and the start of the treatment had no statistically significant effect on chemotherapeutic efficacy of fluoroquinolones.

[Protective properties of doxycycline, rifampicin and sisomycin in experimental pulmonary tularemia of albino mice]. / Zashchitnye svoistva doksitsiklina, rifampitsina i sizomitsina pri éksperimental'noi legochnoi tuliaremii belykh myshei.

The protective effects of doxycycline, rifampicin and sisomicin were compared in a multifactor experiment with animal infection induced by finally dispersed aerosol of a virulent strain of the European variant of the tularemia causative agent and the optimal regimens for the antibiotic use were determined. By the values of the protective effect rifampicin and sisomicin were shown to provide a high percentage of the animal survival: more than 80 and up to 50-70 per cent of the animals survived when the aerosol infective doses were 100 and 10,000 LD50, respectively. A characteristic feature of doxycycline was its activity only in the infection induced by low doses of the biological agent. The optimal course of the antibiotic therapy in inhalation tularemia was 6 to 8 days. The interval of 1 to 3 days between the infection and the therapy start had no significant effect on the protective efficacies of the antibiotics.

[The evaluation of the efficacy of immunization against plague by the modulation in the index of the macrophagal transformation of of the peripheral blood monocytes]. / Otsenka éffektivnosti immunizatsii protiv chumy po moduliatsii pokazatelia makrofagal'noi transformatsii monotsitov perifericheskoi krovi.

The subcutaneous and aerogenous immunization of experimental animals with live dried antiplague vaccine has been shown to modulate the macrophagal transformation index of peripheral blood monocytes (PBM) which correlates with the resistance of the animals to the causative agent of plague. This finding allows to recommend the use of PBM for the evaluation of the effectiveness of immunization with antiplague vaccine.

[An analysis of methods for controlling and regulating the concentration of vaccinal preparations during aerosol immunization]. / Analiz metodov kontrolia i regulirovaniia kontsentratsii vaktsinnykh preparatov pri aérozol'noi immunizatsii.

In this work the methods for the passive control and automatic regulation of the concentration of vaccinal aerosols in static chambers are analyzed. For such analysis, a method for the calculation of the parameters of vaccinal aerosols, taking account of the law of the distribution of particles by their sizes and of the processes of sedimentation and inactivation of microbial aerosols, has been developed. To make empirically established coefficients more precise, the necessary experimental studies have been carried out. High effectiveness of the method providing for the regulation of aerosol mass concentration has been demonstrated, and conditions necessary for effective aerosol immunization have been established.

[Analysis of errors in determining the aspiration dosage in aerosol immunization and in the experimental study of aerogenic infections]. / Analiz pogreshnostei opredeleniia aspiratsionnoi dozy pri aspiratsionnoi dozy pri aérozol'noi immunizatsii i éksperimental'nom izuchenii aérogennykh infektsii.

The present work deals with the factors affecting the accuracy of the dosage of vaccinal preparations in the aerosol immunization of animals in a dynamic chamber. The method for analysis of errors in the determination of the aspiration dose is proposed. The method is based on mathematical models describing the main parameters of aerosols and the respiratory factors of the animals, the errors of the techniques and equipment used for immunization. The errors in the determination of the dose have been shown to decrease the reliability of results obtained in the evaluation of respiratory ED50 of vaccinal preparations and to impose limits on the required number of experimental animals.