Ethnobotanical, pharmacological, phytochemical, and clinical investigations on Moroccan medicinal plants traditionally used for the management of renal dysfunctions.

ETHNOPHARMACOLOGICAL RELEVANCE: Renal disease is a significant public health concern that affects people all over the world. The main limitations of conventional therapy are the adverse reaction on human health and the expensive cost of drugs. Indeed, it is necessary to develop new therapeutic strategies that are less expensive and have fewer side effects. As a consequence of their natural compounds, medicinal plants can be used as an alternative therapy to cure various ailments including kidney diseases. OBJECTIVE: of the study: This review paper has two principal goals: (1) to inventory and describe the plants and their ancestral use by Moroccan society to cure renal problems, (2) to link traditional use with scientific confirmations (preclinical and clinical). METHODS: To analyze pharmacological effects, phytochemical, and clinical trials of plants, selected for renal therapy, a bibliographical search was undertaken by examining ethnobotanical investigations conducted in Morocco between 1991 and 2019 and consulting peer-reviewed papers from all over the world. RESULTS: Approximately 290 plant species, spanning 81 families and 218 genera have been reported as being utilized by Moroccans to manage renal illness. The most frequently mentioned species in Morocco were Herniaria hirsuta subsp. cinerea (DC.), Petroselinum crispum (Mill.) Fuss and Rosmarinus officinalis L. The leaves were the most frequently used plant parts, followed by the whole plant. Decoction and infusion were the most popular methods of preparation. A record of 71 plant species was studied in vitro and/or in vivo for their therapeutic efficacy against kidney disorders, including 10 plants attempting to make it to the clinical stage. Twenty compounds obtained from 15 plants have been studied for the treatment of kidney diseases. CONCLUSION: Medicinal herbs could be a credible alternative therapy for renal illness. However, additional controlled trials are required to confirm their efficiency in patients with kidney failure. Overall, this work could be used as a database for future exploration.

Ethnobotanical survey of medicinal plants used by people in Oriental Morocco to manage various ailments.

ETHNOPHARMACOLOGICAL RELEVANCE: This document presents the uses of plants in traditional herbal medicines in Oriental Morocco. It also determines the homogeneity of informant knowledge in medicinal plants suitable for different ailment categories and the most preferred plant species used to treat each illness category in the study area. MATERIALS AND METHODS: The ethnobotanical information was obtained from 3151 inhabitants who were 20 years and older in five different areas of Oriental Morocco region. The data were analyzed through informant consensus factor (ICF) and frequency of uses (FC). RESULTS: The results indicated that 65.7% of the participants interviewed used medicinal plants to treat 23 ailments. The inventory of medicinal plants is summarized in a synoptic table, which contains the scientific and vernacular names of the plant, the part of the plant and the preparation used and the therapeutic indication. Extensive investigations have brought to light 148 medicinal plants belonging to 60 families; of these, 108 are used for the disorders of the digestive system, 74 for diabetes, 73 for dermatological problems, 66 for allergy, 66 for cardiovascular disorders and 63 for respiratory problems. In this region, the most frequently used plants including Origanum compactum Benth., Trigonella foenum graecum L., Lavandula dentata L., Mentha pulegium L., Nigella sativa L., Rosmarinus officinalis L., Lippia citriodora L., Tetraclinis articulata Benth., and Atemisia herba-alba Asso. Lamiaceae and Asteraceae are the dominant locally used families. Most medicines were prepared in the form of powder and used orally. Leaves were the most frequently used plant part. Gastro-intestinal ailments have high ICF (0.92) whereas pathologies of the circulatory and ophthalmological uses have low ICF (0.22 and 0.24, respectively). CONCLUSION: Oriental Morocco boasts an extensive phytotherapy knowledge base and ICF values indicated that there was high agreement in the use of plants in gastro-intestinal ailment category among the users. The frequency use value (FC) indicated that these plants are the most preferred species used in study areas. These preferred plant species could be prioritized for conservation and subjected to further studies related to chemical screening for their authenticity.