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1.
Complement Ther Med ; 23(5): 652-7, 2015 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-26365444

RESUMO

BACKGROUND: The effect of nutrition and dietary supplements as environmental factors has been suggested as possible factors affecting both disease risk and progression in on the course of multiple sclerosis with complex genetic-risk profiles. This study was aimed to assess regulation of surface-membrane enzymes such as Delta-6-desaturase (FADS2), secretory Phospholipase A2(sPLA2) by hemp seed and evening primrose oils as well as Hot-natured dietary intervention in relapsing remitting multiple sclerosis (RRMS) patients. METHODS AND MATERIALS: In this double blind, randomized trial, 100 RRMS patients with Extended disability status score (EDSS)<6 were allocated into 3 groups: "Group A" who received co-supplemented hemp seed and evening primrose oils along with advised Hot nature diet; "Group B", who received olive oil; "Group C", who received the co-supplemented oils. Clinically EDSS and functional score as well as biochemical parameters [blood cells polyunsaturated fatty acid (PUFA), FADS2, sPLA2] were assessed at baseline and after 6 months. RESULTS: Mean follow-up was 180±2.9SD days (N=65, 23 M and 42 F aged 34.25±8.07 years with disease duration 6.80±4.33 years). There was no significant difference in studies parameters at baseline. After 6 months, significant improvements in EDSS and functional score were found in the groups A and C while EDSS and pyramidal score showed significant increase in group B. Alteration of biochemical parameters showed improvement in groups A and C whereas there was worsening condition for group B after the intervention. CONCLUSION: The co-supplemented hemp seed and evening primrose oils with Hot nature diet can have beneficial effects in improving clinical symptoms and signs in RRMS patients which were confirmed by regulation of surface-membrane enzymes.


Assuntos
Cannabis , Ácidos Graxos Dessaturases/sangue , Ácidos Linoleicos/uso terapêutico , Esclerose Múltipla/dietoterapia , Fosfolipases A2 Secretórias/sangue , Óleos de Plantas/uso terapêutico , Sementes , Ácido gama-Linolênico/uso terapêutico , Adulto , Método Duplo-Cego , Feminino , Humanos , Ácidos Linoleicos/administração & dosagem , Masculino , Oenothera biennis , Óleos de Plantas/administração & dosagem , Ácido gama-Linolênico/administração & dosagem
2.
Complement Ther Med ; 22(6): 986-93, 2014 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-25453518

RESUMO

BACKGROUND: It is unknown whether diets with a high dietary total antioxidant capacity (TAC) can modify oxidative stress, low-grade inflammation, or liver dysfunction, all of which are risk factors for multiple sclerosis disease. This study assesses alanine amino-transferase (ALT), aspartate-aminotransferase (AST) and gamma-glutamyl transferase (GGT) activities in MS patients treated with co-supplemented hemp seed and evening primrose oils as well as Hot-nature diet and the therapeutic potential this intervention. METHODS AND MATERIALS: In this double blind, randomized trial, 100 MS patients with EDSS<6 were allocated into 3 groups: "group A", who received co-supplemented hemp seed and evening primrose oils with advised Hot-nature diet; "group B",who received olive oil; and "group C", who received the co-supplemented oils. Clinically, EDSS as well as serum level of liver enzymes (GGT, AST, and ALT) were assessed at baseline and after 6 months. RESULTS: Mean follow-up was 180±2.9 SD days (N=65, 23 M and 42 F aged 34.25±8.07 years with disease duration of 6.80±4.33 years). There was no significant difference in the study parameters at baseline. Serum levels of liver enzymes (GGT, AST, and ALT) were serially monitored. Intervention was associated with liver function alteration in three groups. Significance decreased in EDSS score and the levels of liver enzymes were found in groups A and C, whereas elevated serum liver enzymes and EDSS score were observed in group B after the intervention. CONCLUSION: Selecting foods according to their Total antioxidant capacity such as co-supplemented hemp seed and evening primrose oils with Hot-nature diet affects antioxidant intake and can have beneficial effects on improving EDSS score and activity of liver enzymes in RRMS patients.


Assuntos
Cannabis , Ácidos Linoleicos/administração & dosagem , Fígado/enzimologia , Esclerose Múltipla/dietoterapia , Esclerose Múltipla/enzimologia , Óleos de Plantas/administração & dosagem , Ácido gama-Linolênico/administração & dosagem , Adolescente , Adulto , Método Duplo-Cego , Feminino , Humanos , Fígado/efeitos dos fármacos , Masculino , Pessoa de Meia-Idade , Oenothera biennis , Sementes , Adulto Jovem
3.
Iran J Neurol ; 12(2): 51-5, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-24250902

RESUMO

BACKGROUND: Headache is one of the most disturbing symptoms with common neurological signs. Variations in optic nerve perfusion quality or retinal microcirculation may end up in ganglion cell damage in patients with migraine. METHODS: Sixty patients diagnosed with migraine and thirty normal individuals were evaluated in groups including migraine with aura, migraine without aura and controls. Retinal nerve fiber layer (RNFL) thickness was measured using stratus optical coherence tomography (OCT™) and then was compared in case and control groups. RESULTS: RNFL thickness was only significantly thinner in nasal quadrant in migraineurs compared to the control group. Other parameters showed no difference between the two groups and besides there was no statistically difference between the two migraine subgroups. CONCLUSION: Given the significant difference in nasal quadrant RNFL thickness between the migraineurs and normal individuals, we might be able to defend the retinal blood flow decrease theory in migraine; however, multicentre studies with larger samples seem mandatory.

4.
Complement Ther Med ; 21(5): 473-80, 2013 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-24050582

RESUMO

BACKGROUND: Multiple sclerosis (MS) is the most chronic and inflammatory disorder. Because of limited efficacy and adverse side effects, identifying novel therapeutic and protective agents is important. This study was aimed to assess the potential therapeutic effects of hemp seed and evening primrose oils as well as Hot-nature dietary intervention on RRMS patients. METHODS AND MATERIALS: In this double blind, randomized trial, 100 MS patients with EDSS<6 were allocated into 3 groups: "Group A" who received co-supplemented hemp seed and evening primrose oils with advised Hot-nature diet, "Group B" who received olive oil, "Group C" who received the co-supplemented oils. Mizadj, clinically EDSS and relapse rate as well as immunological factors (IL-4, IFN-γ and IL-17) were assessed at baseline and after 6 months. RESULTS: Mean follow-up was 180±2.9 SD days (N=65, 23 M and 42 F aged 34.25±8.07 years with disease duration 6.80±4.33 years). There was no significant difference in studies parameters at baseline. After 6 months, significant improvements in Mizadj, EDSS and relapse rate were found in the groups A and C, while the group B showed a border significant decrease in relapse rate. Immunological parameters showed improvement in groups A and C, whereas there was worsening condition for group B after the intervention. CONCLUSION: The co-supplemented hemp seed and evening primrose oils with Hot-nature diet have beneficial effects in improving of clinical score in RRMS patients which were confirmed by immunological findings.


Assuntos
Cannabis , Dieta , Esclerose Múltipla/tratamento farmacológico , Oenothera biennis , Fitoterapia/métodos , Extratos Vegetais/administração & dosagem , Óleos de Plantas/administração & dosagem , Adulto , Citocinas/sangue , Método Duplo-Cego , Ácidos Graxos Insaturados/metabolismo , Feminino , Humanos , Inflamação , Irã (Geográfico) , Masculino , Medicina Tradicional , Redes e Vias Metabólicas , Esclerose Múltipla/sangue , Esclerose Múltipla/dietoterapia , Esclerose Múltipla/imunologia , Sementes
5.
Immunol Invest ; 42(8): 737-48, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23876169

RESUMO

CXCL8 and its receptors (CXCR1 and CXCR2) play important roles in CNS development, neuronal survival, modulation of excitability, and neuroimmune response. The aim of this study is to evaluate gene expression of CXCL8 and CXCR1/CXCR2 in peripheral blood cells (PBCs) of Iranian patients with relapsing remitting (RR) form of Multiple sclerosis (MS). We explored the mRNA expression of CXCL8 and its receptors in PBCs of 49 RR-MS patients in remitting status and 60 healthy controls by quantitative Real-Time PCR. Median expression of CXCL8 mRNA in peripheral blood of MS patients decreased more than 3-fold compared to control group (p < 0.001), while there were not significant differences in CXCR1 and CXCR2 gene expression between MS patients and healthy subjects (p = 0.159 and p = 0.248, respectively). There was a significant negative correlation of CXCR2 expression with EDSS (rs = -0.432, p = 0.004). It appears that decreased expression of CXCL8 may lead to a raised risk of MS.


Assuntos
Interleucina-8/metabolismo , Esclerose Múltipla/imunologia , Receptores de Interleucina-8A/metabolismo , Receptores de Interleucina-8B/metabolismo , Adulto , Feminino , Regulação da Expressão Gênica , Humanos , Interleucina-8/genética , Irã (Geográfico) , Masculino , Pessoa de Meia-Idade , RNA Mensageiro/análise , Receptores de Interleucina-8A/genética , Receptores de Interleucina-8B/genética , Risco , Adulto Jovem
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