[The characteristics of patients hospitalized in a general therapy department in connection with emergency pulmonary states]. / Kharakterystyka khvorykh, hospitalizovanykh v zahal'noterapevtychne viddilennia u zv'iazku z nevidkladnymy pul'monolohichnymi stanamy.

An analysis was done of urgent pulmonologic states, because of which states those hospitalized had been sent to a general therapy department. Over the year, 237 persons had been admitted into hospital through emergency first aid service, with urgent pulmonologic states making up 51.5% (n = 122) of the total, bronchial asthma (BA) and acute lung inflammation (ALI) predominating (55 and 55 subjects respectively). BA patients were found to be unable to recognize the worsening of their state in good time, they fail to keep in touch with pulmonologists and district hospitals. The main reason why ALI patients had been admitted into hospital on an urgent basis was intoxication syndrome and broncho-obstructive syndrome. In 20% of ALI hospitalizations, there was divergence in diagnoses (referral versus clinical ones).

[The results of bronchoscopy in patients of different ages with chronic bronchitis]. / Rezul'taty bronkhoskopii u bol'nykh khronicheskim bronkhitom razlichnogo vozrasta.

Bronchological examination of 1769 patients with chronic bronchitis (CHB) of different age groups revealed that the development of that or another form of endobronchitis (catarrhal, purulent, atrophic) did not depend on the age, duration of disease and other causes. It may be suggested that the genetic predisposition to development of definite forms of endobronchitis. Apparently, most rigidly determined is the development of the atrophic form of endobronchitis as its frequency was similar in all groups, in different forms of CHB.

[Clinico-genetic research in chronic bronchitis]. / Kliniko-geneticheskie issledovaniia pri khronicheskom bronkhite.

Clinico-genetic analysis was performed in 530 patients with chronic bronchitis (CB) and in 760 healthy persons. The frequency of aggravated heredity in the patients' parents was significantly higher than that in the healthy persons' parents (21.3 +/- 1.8 and 12.1 +/- 1.2%, respectively, P less than 0.05), this predominance being associated with such diseases as chronic bronchitis and bronchial asthma. A study of a type of familial aggravation has shown that the probability of CB development in descendants increases substantially if mother suffers from CB, CB morbidity among girls being significantly higher than that among boys. The results of a sib analysis also confirm an important role of the genetic mechanisms in CB development. Investigations using a twin method (14 pairs of monozygotic and 39 pairs of dizygotic twins) have demonstrated that genetic factors account for 41% in the formation of the leading CB symptoms while exogenous factors account for 59%. A study of the blood antigens ABO, Rh, MN, P, Hp has revealed different sensitivity of persons with different genetic blood markers to CB. Differences in the frequency of antigen combinations were also revealed in the patients and in the healthy persons. The results obtained indicate the appropriateness of further development of genetic investigations in pulmonology.