1.
Tetrahedron Lett
; 45(16): 3269-3272, 2010 May 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20376298
RESUMO
The fully substituted hydroisobenzofuran core of the massileunicellins containing 8 contiguous stereocenters was prepared in 12 steps from (S)-(+)-carvone. Noteworthy elements of the synthesis include a one-step oxidative rearrangement/epoxidation, a novel stereoselective directed reduction of a keto diol, and a directed hydrogenation of a congested tetrasubstituted alkene.