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Andrologia ; 41(3): 176-83, 2009 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-19400852

RESUMO

This work aimed to assess the efficacy of haeme oxygenase-1 (HO-1) cDNA-liposome complex transfer as a mediator of erectile signalling in aged rats. One hundred and fifty aged white albino rats were equally divided into five groups: controls, rats receiving lipofectamine, rats receiving intracorporeal HO-1 cDNA-lipsome complex, rats receiving HO-1 cDNA-liposome complex plus nitric oxide synthase (NOS) inhibitor, and rats receiving HO-1 cDNA-liposome complex plus HO inhibitor. Six rats were killed from each group after 12, 24 and 48 h, and after1 and 2 weeks. In dissected cavernous tissues, the following were assessed: HO-1 gene expression, Western blot for HO-1, HO enzyme activity, cGMP and histopathology. The results showed that HO-1 cDNA-liposome complex transfer led to a significant increase in cavernous tissue HO-1 protein, HO-1 gene expression, HO enzyme activity and cGMP up to 1 week. NOS inhibition exhibited no effect on HO-1 gene enhancement of cavernous tissue HO enzyme activity or cGMP, whereas inhibition of HO significantly decreased these parameters. Histopathology of cavernous tissue demonstrated a significant dilatation of helicine arteries in HO-1 cDNA-liposome complex treated group after 48 h compared with the controls. It is concluded that HO-1 cDNA-liposome complex transfer augments cavernous tissue cGMP with subsequent sinusoidal relaxation.


Assuntos
Disfunção Erétil/terapia , Heme Oxigenase-1/uso terapêutico , Lipossomos/uso terapêutico , Ereção Peniana/fisiologia , Envelhecimento , Animais , Monóxido de Carbono/farmacologia , DNA Complementar/uso terapêutico , Ativação Enzimática/efeitos dos fármacos , Expressão Gênica , Técnicas de Transferência de Genes , Guanilato Ciclase/metabolismo , Heme Oxigenase-1/biossíntese , Masculino , NG-Nitroarginina Metil Éster/uso terapêutico , Ereção Peniana/genética , Ratos , Receptores Citoplasmáticos e Nucleares/metabolismo , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Guanilil Ciclase Solúvel
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