Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Mais filtros










Intervalo de ano de publicação
1.
Acta Cir Bras ; 30(1): 34-45, 2015 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25627269

RESUMO

PURPOSE: To evaluate the protective effects of chilling the bile ducts with cold (5°C) 5% glucose solution (GS) during radiofrequency (RF) administration. METHODS: Twenty male pigs (3 mos. old; 25-30 kg) were subjected to RF delivery with chilling (experimental group, N=10) or without chilling (control group, N=10). Half of the animals in each group were euthanized immediately after the operation, and half were euthanized one week later. The following histological variables in relation to the bile ducts were evaluated by a pathologist (blind examiner): degenerative changes to the epithelium; epithelial necrosis; ulceration, regenerative changes of the epithelium; polymorphonuclear neutrophil infiltration; and thermal effects. RESULTS: The experimental group (88 bile ducts examined) showed reduced thermal damage relative to the control group (86 bile ducts examined) as demonstrated by significant differences in the following histopathological parameters: epithelial detachment of biliary epithelium (84.1% vs. 59.3%; p<0.006); elongation/palisade arrangement of nuclei (65.1% vs. 87.5%; p<0.001); pseudo-goblet cells (32.9% vs. 56.8%; p<0.001). CONCLUSION: Infusion of 5% glucose solution (5°C) has a protective effect on bile ducts subjected to heat (95-110°C, 12 min) from radiofrequency thermal ablation device.


Assuntos
Ductos Biliares/lesões , Queimaduras/prevenção & controle , Ablação por Cateter/efeitos adversos , Crioterapia/métodos , Glucose/farmacologia , Fígado/cirurgia , Animais , Doenças dos Ductos Biliares/prevenção & controle , Ductos Biliares/patologia , Queimaduras/etiologia , Ablação por Cateter/métodos , Temperatura Alta/efeitos adversos , Masculino , Perfusão , Substâncias Protetoras/farmacologia , Reprodutibilidade dos Testes , Suínos , Fatores de Tempo , Resultado do Tratamento
2.
Acta cir. bras ; 30(1): 34-45, 01/2015. tab, graf
Artigo em Inglês | LILACS | ID: lil-735704

RESUMO

PURPOSE: To evaluate the protective effects of chilling the bile ducts with cold (5°C) 5% glucose solution (GS) during radiofrequency (RF) administration. METHODS: Twenty male pigs (3 mos. old; 25-30 kg) were subjected to RF delivery with chilling (experimental group, N=10) or without chilling (control group, N=10). Half of the animals in each group were euthanized immediately after the operation, and half were euthanized one week later. The following histological variables in relation to the bile ducts were evaluated by a pathologist (blind examiner): degenerative changes to the epithelium; epithelial necrosis; ulceration, regenerative changes of the epithelium; polymorphonuclear neutrophil infiltration; and thermal effects. RESULTS: The experimental group (88 bile ducts examined) showed reduced thermal damage relative to the control group (86 bile ducts examined) as demonstrated by significant differences in the following histopathological parameters: epithelial detachment of biliary epithelium (84.1% vs. 59.3%; p<0.006); elongation/palisade arrangement of nuclei (65.1% vs. 87.5%; p<0.001); pseudo-goblet cells (32.9% vs. 56.8%; p<0.001). CONCLUSION: Infusion of 5% glucose solution (5°C) has a protective effect on bile ducts subjected to heat (95-110°C, 12 min) from radiofrequency thermal ablation device. .


Assuntos
Animais , Masculino , Ductos Biliares/lesões , Queimaduras/prevenção & controle , Ablação por Cateter/efeitos adversos , Crioterapia/métodos , Glucose/farmacologia , Fígado/cirurgia , Doenças dos Ductos Biliares/prevenção & controle , Ductos Biliares/patologia , Queimaduras/etiologia , Ablação por Cateter/métodos , Temperatura Alta/efeitos adversos , Perfusão , Substâncias Protetoras/farmacologia , Reprodutibilidade dos Testes , Suínos , Fatores de Tempo , Resultado do Tratamento
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...