RESUMO
This study analyzes modern views on the history, variants, age at diagnosis of trilateral retinoblastoma, median time from retinoblastoma to trilateral retinoblastoma, the largest size and percentage of trilateral retinoblastoma among retinoblastoma cases, functions of pineal gland, genetics, ocular and intracranial histology, diagnosis, treatment, therapy results, survival rates and frequency of screening of trilateral retinoblastoma.
Assuntos
Neoplasias da Retina/diagnóstico , Neoplasias da Retina/epidemiologia , Retinoblastoma/diagnóstico , Retinoblastoma/epidemiologia , Distribuição por Idade , Idade de Início , Animais , Criança , Pré-Escolar , Progressão da Doença , Feminino , Humanos , Incidência , Lactente , Masculino , Programas de Rastreamento/métodos , Glândula Pineal/fisiopatologia , Neoplasias da Retina/fisiopatologia , Neoplasias da Retina/terapia , Retinoblastoma/fisiopatologia , Retinoblastoma/terapia , Distribuição por Sexo , Taxa de SobrevidaRESUMO
Incidence rate, age-adjusted and standardized incidence and mortality of malignant eye tumours (METs) in Uzbekistan in 1978-1998 and professional, ethnic, environmental, and geographical factors which could influence it are analyzed. Before 1978, there was no information about patients with METs in Uzbekistan. We gathered 4872 primary new cases, of whom 79.7% (3882 patients) were treated in our department. All samples were statistically tested. Age-adjusted MET incidence has a peak in the 60-69 age subgroup. The highest incidence was in "non-local" ethnic group. Eyelid tumours occurred most frequently, followed by conjunctival, intraocular and orbital tumours. Urban and rural females had higher incidence than urban and rural males. For 10 years, standardized incidence has increased 2.3 and mortality 6.0 times. The highest incidence and mortality were in Karakalpakstan and Khorezm Wiloyat.
Assuntos
Neoplasias Oculares/epidemiologia , Adolescente , Adulto , Distribuição por Idade , Idoso , Idoso de 80 Anos ou mais , Etnicidade/estatística & dados numéricos , Neoplasias Oculares/classificação , Neoplasias Oculares/mortalidade , Neoplasias Oculares/prevenção & controle , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Ocupações/estatística & dados numéricos , Fatores de Risco , Distribuição por Sexo , Taxa de Sobrevida , Uzbequistão/epidemiologiaRESUMO
Retinoblastoma incidence and mortality rates associated with age, sex, and ethnic background between 1978 and 1999 have been studied. Statistical analysis of normal and standardised incidence rates was performed on 972 patients. For 21 years, annual retinoblastoma incidence for both sexes has increased. There was no difference in cumulative retinoblastoma incidence between males and females. Among all ethnic groups living in Uzbekistan, the highest retinoblastoma incidence occurred among Tartars and Uzbeks who frequently marry their family members. There was no difference in mortality of males and females. Over a 5-year period from the moment of diagnosis, almost every third child with retinoblastoma died of metastases. Most of retinoblastoma cases were represented by patients with late diagnosis. Before 1978, there was no information in Uzbekistan about the number of patients with malignant eye tumours, including retinoblastoma.