A computational account of the development and evolution of psychotic symptoms.

The mechanisms of psychotic symptoms like hallucinations and delusions are often investigated in fully-formed illness, well after symptoms emerge. These investigations have yielded key insights, but are not well-positioned to reveal the dynamic forces underlying symptom formation itself. Understanding symptom development over time would allow us to identify steps in the pathophysiological process leading to psychosis, shifting the focus of psychiatric intervention from symptom alleviation to prevention. We propose a model for understanding the emergence of psychotic symptoms within the context of an adaptive, developing neural system. We will make the case for a pathophysiological process that begins with cortical hyperexcitability and bottom-up noise transmission, which engenders inappropriate belief formation via aberrant prediction error signaling. We will argue that this bottom-up noise drives learning about the (im)precision of new incoming sensory information because of diminished signal-to-noise ratio, causing an adaptive relative over-reliance on prior beliefs. This over-reliance on priors predisposes to hallucinations and covaries with hallucination severity. An over-reliance on priors may also lead to increased conviction in the beliefs generated by bottom-up noise and drive movement toward conversion to psychosis. We will identify predictions of our model at each stage, examine evidence to support or refute those predictions, and propose experiments that could falsify or help select between alternative elements of the overall model. Nesting computational abnormalities within longitudinal development allows us to account for hidden dynamics among the mechanisms driving symptom formation and to view established symptomatology as a point of equilibrium among competing biological forces.

Evidence for Reduced Sensory Precision and Increased Reliance on Priors in Hallucination-Prone Individuals in a General Population Sample.

BACKGROUND: There is increasing evidence that people with hallucinations overweight perceptual beliefs relative to incoming sensory evidence. Past work demonstrating prior overweighting has used simple, nonlinguistic stimuli. However, auditory hallucinations in psychosis are often complex and linguistic. There may be an interaction between the type of auditory information being processed and its perceived quality in engendering hallucinations. STUDY DESIGN: We administered a linguistic version of the conditioned hallucinations (CH) task to an online sample of 88 general population participants. Metrics related to hallucination-proneness, hallucination severity, stimulus thresholds, and stimulus detection rates were collected. Data were used to fit parameters of a Hierarchical Gaussian Filter (HGF) model of perceptual inference to determine how latent perceptual states influenced task behavior. STUDY RESULTS: Replicating past results, higher CH rates were observed both in those with recent hallucinatory experiences as well as participants with high hallucination-proneness; CH rates were positively correlated with increased prior weighting; and increased prior weighting was related to hallucination severity. Unlike past results, participants with recent hallucinatory experiences as well as those with higher hallucination-proneness had higher stimulus thresholds, lower sensitivity to stimuli presented at the highest threshold, and had lower response confidence, consistent with lower precision of sensory evidence. CONCLUSIONS: We replicate the finding that increased CH rates and recent hallucinations correlate with increased prior weighting using a linguistic version of the CH task. Results support a role for reduced sensory precision in the interplay between prior weighting and hallucination-proneness.

Barriers and solutions to the adoption of translational tools for computational psychiatry.

Computational psychiatry is a field aimed at developing formal models of information processing in the human brain, and how alterations in this processing can lead to clinical phenomena. There has been significant progress in the development of tasks and how to model them, presenting an opportunity to incorporate computational psychiatry methodologies into large- scale research projects or into clinical practice. In this viewpoint, we explore some of the barriers to incorporation of computational psychiatry tasks and models into wider mainstream research directions. These barriers include the time required for participants to complete tasks, test-retest reliability, limited ecological validity, as well as practical concerns, such as lack of computational expertise and the expense and large sample sizes traditionally required to validate tasks and models. We then discuss solutions, such as the redesigning of tasks with a view toward feasibility, and the integration of tasks into more ecologically valid and standardized game platforms that can be more easily disseminated. Finally, we provide an example of how one task, the conditioned hallucinations task, might be translated into such a game. It is our hope that interest in the creation of more accessible and feasible computational tasks will help computational methods make more positive impacts on research as well as, eventually, clinical practice.

Conditioned Hallucinations and Prior Overweighting Are State-Sensitive Markers of Hallucination Susceptibility.

BACKGROUND: Recent advances in computational psychiatry have identified latent cognitive and perceptual states that predispose to psychotic symptoms. Behavioral data fit to Bayesian models have demonstrated an overreliance on priors (i.e., prior overweighting) during perception in select samples of individuals with hallucinations, corresponding to increased precision of prior expectations over incoming sensory evidence. However, the clinical utility of this observation depends on the extent to which it reflects static symptom risk or current symptom state. METHODS: To determine whether task performance and estimated prior weighting relate to specific elements of symptom expression, a large, heterogeneous, and deeply phenotyped sample of hallucinators (n = 249) and nonhallucinators (n = 209) performed the conditioned hallucination (CH) task. RESULTS: We found that CH rates predicted stable measures of hallucination status (i.e., peak frequency). However, CH rates were more sensitive to hallucination state (i.e., recent frequency), significantly correlating with recent hallucination severity and driven by heightened reliance on past experiences (priors). To further test the sensitivity of CH rate and prior weighting to symptom severity, a subset of participants with hallucinations (n = 40) performed a repeated-measures version of the CH task. Changes in both CH frequency and prior weighting varied with changes in auditory hallucination frequency on follow-up. CONCLUSIONS: These results indicate that CH rate and prior overweighting are state markers of hallucination status, potentially useful in tracking disease development and treatment response.

Measuring Voluntary Control Over Hallucinations: The Yale Control Over Perceptual Experiences (COPE) Scales.

Auditory verbal hallucinations (AVH) frequently cause significant distress and dysfunction, and may be unresponsive to conventional treatments. Some voice-hearers report an ability to fully control the onset and offset of their AVH, making them significantly less disruptive. Measuring and understanding these abilities may lead to novel interventions to enhance control over AVH. Fifty-two voice-hearers participated in the pilot study. 318 participants with frequent AVH participated in the validation study. A pool of 59 items was developed by a diverse team including voice-hearers and clinicians. After the pilot study, 35 items were retained. Factorial structure was assessed with exploratory (EFA, n = 148) and confirmatory (CFA, n = 170) factor analyses. Reliability and convergent validity were assessed using a comprehensive battery of validated phenomenological and clinical scales. CFA on the final 18 items supported two factors for a Methods of Control Scale (5 items each, average ω = .87), and one factor for a Degree of Control Scale (8 items, average ω = .95). Correlation with clinical measures supported convergent validity. Degree of control was associated with positive clinical outcomes in voice-hearers both with and without a psychosis-spectrum diagnosis. Degree of control also varied with quality of life independently of symptom severity and AVH content. The Yale control over perceptual experiences (COPE) Scales robustly measure voice-hearers' control over AVH and exhibit sound psychometric properties. Results demonstrate that the capacity to voluntarily control AVH is independently associated with positive clinical outcomes. Reliable measurement of control over AVH will enable future development of interventions meant to bolster that control.

Development of Voluntary Control Over Voice-Hearing Experiences: Evidence From Treatment-Seeking and Non-Treatment-Seeking Voice-Hearers.

Voluntary control over voice-hearing experiences is one of the most consistent predictors of functioning among voice-hearers. However, control over voice-hearing experiences is likely to be more nuanced and variable than may be appreciated through coarse clinician-rated measures, which provide little information about how control is conceptualized and developed. We aimed to identify key factors in the evolution of control over voice-hearing experiences in treatment-seeking (N = 7) and non-treatment-seeking (N = 8) voice-hearers. Treatment-seeking voice-hearers were drawn from local chapters of the Connecticut Hearing Voices Network, and non-treatment-seeking voice-hearers were recruited from local spiritually oriented organizations. Both groups participated in a clinical assessment, and a semi-structured interview meant to explore the types of control exhibited and how it is fostered. Using Grounded Theory, we identified that participants from both groups exerted direct and indirect control over their voice-hearing experiences. Participants that developed a spiritual explanatory framework were more likely to exert direct control over the voice-hearing experiences than those that developed a pathologizing framework. Importantly, despite clear differences in explanatory framework and distress because of their experiences, both groups underwent similar trajectories to develop control and acceptance over their voice-hearing experiences. Understanding these factors will be critical in transforming control over voice-hearing experiences from a phenomenological observation to an actionable route for clinical intervention.

Family Communication in Long-Term Care During a Pandemic: Lessons for Enhancing Emotional Experiences.

OBJECTIVE: Family visits with residents at long-term care (LTC) facilities have been restricted during the COVID-19 pandemic. The objective was to examine what communication methods, other than in-person visits, during the pandemic were associated with greater positive and lower negative emotional experiences for LTC residents and their family members and friends. DESIGN: Cross-sectional. SETTING: Nationally targeted online survey. PARTICIPANTS: One hundred sixty-one community-dwelling adults who had a family member or friend in a LTC facility. MEASUREMENTS: The Positive and Negative Affect Scale was used to assess participant's own emotions and perceived resident emotions during the pandemic. Questions were asked about nine communication methods other than physical visits (e.g., phone, video-conference, e-mail, and letters) in terms of frequency of use during the pandemic. Sociodemographics, resident health, and facility factors were assessed and used as covariates where indicated. RESULTS: During the pandemic, greater phone frequency was associated with less participant negative emotions (ß = -0.17). Greater e-mail frequency was associated with more perceived resident positive emotions (ß = 0.28). Greater frequency of letters delivered by staff was associated with more participant negative emotions (ß = 0.23). Greater frequency of letters delivered by staff and the postal service were associated with more perceived resident negative emotions (ß = 0.28; ß = 0.34, respectively). CONCLUSION: These findings highlight the importance of synchronous, familiar methods of communication like the phone and email between families and LTC residents to maintain their emotional well-being when in-person visits are restricted.

Orthographic processing is a key predictor of reading fluency in good and poor readers in a transparent orthography.

We used structural equation modeling to investigate sources of individual differences in oral reading fluency in a transparent orthography, Russian. Phonological processing, orthographic processing, and rapid automatized naming were used as independent variables, each derived from a combination of two scores: phonological awareness and pseudoword repetition, spelling and orthographic choice, and rapid serial naming of letters and digits, respectively. The contribution of these to oral text-reading fluency was evaluated as a direct relationship and via two mediators, decoding accuracy and unitized reading, measured with a single-word oral reading test. The participants were "good" and "poor" readers, i.e., those with reading skills above the 90th and below the 10th percentiles (n = 1,344, grades 2-6, St. Petersburg, Russia). In both groups, orthographic processing skills significantly contributed to fluency and unitized reading, but not to decoding accuracy. Phonological processing skills did not contribute directly to reading fluency in either group, while contributing to decoding accuracy and, to a lesser extent, to unitized reading. With respect to the roles of decoding accuracy and unitized reading, the results for good and poor readers diverged: in good readers, unitized reading, but not decoding accuracy, was significantly related to reading fluency. For poor readers, decoding accuracy (measured as pseudoword decoding) was related to reading fluency, but unitized reading was not. These results underscore the importance of orthographic skills for reading fluency even in an orthography with consistent phonology-to-orthography correspondences. They also point to a qualitative difference in the reading strategies of good and poor readers.

Paired Associate Learning Tasks and their Contribution to Reading Skills.

Associative learning has been identified as one of several non-linguistic processes involved in reading acquisition. However, it has not been established whether it is an independent process that contributes to reading performance on its own or whether it is a process that is embedded in other linguistic skills (e.g., phonological awareness or phonological memory) and, therefore, contributing to reading performance indirectly. Research has shown that performance on tasks assessing associative learning, e.g., paired-associate learning (PAL) tasks, is lower in children with specific reading difficulties compared to typical readers. We explored the differential associations of two distinct verbal-visual PAL tasks (the Bala Bbala Graphogame, BBG, and a Foreign Language Learning Task, FLLT) with reading skills (word reading and pseudo-word decoding), controlling for phonological awareness, rapid naming, and letter and digit span in children at risk for reading disabilities and their typically developing peers. Our study sample consisted of 110 children living in rural Zambia, ranging in age from 7 to 18 years old (48.1% female). Multivariate analyses of covariance were used to explore the group differences in reading performance. Repeated-measures ANCOVA was used to examine children's learning across the PAL tasks. The differential relationships between both PAL tasks and reading performance were explored via structural equation modeling. The main result was that the children at risk for reading difficulties had lower performance on both PAL tasks. The BBG was a significant predictor for both word reading and pseudo-word decoding, whereas the FLLT-only for word reading. Performance on the FLLT partially mediated the association between phonological awareness and word reading. These results illustrate the partial independence of associative learning from other reading-related skills; the specifics of this relationship vary based on the type of PAL task administered.

Reading skills, creativity, and insight: exploring the connections

Studies of the relationship between creativity and specific reading disabilities have produced inconclusive results. We explored their relationship in a sample of 259 college students (age range: 17 to 38 years-old) from three Chilean universities. The students were tested on their verbal ability, creativity, and insight. A simple linear regression was performed on the complete sample, and on high- and low-achievement groups that were formed based on reading test scores. We observed a significant correlation in the total sample between outcomes on the verbal ability tasks, and on the creativity and insight tasks (range r =. 152 to r =. 356, ps <.001). Scores on the reading comprehension and phonological awareness tasks were the best predictors of performance on creativity and insight tasks (range β = .315 to β = .155, ps <.05). A comparison of the low- and high-scoring groups on verbal ability tasks yielded results to the same effect. These findings do not support the hypothesis that specific reading disability is associated with better performance on creative tasks. Instead, higher verbal ability was found to be associated with higher creativity and insight (AU)

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Reading skills, creativity, and insight: exploring the connections.

Studies of the relationship between creativity and specific reading disabilities have produced inconclusive results. We explored their relationship in a sample of 259 college students (age range: 17 to 38 years-old) from three Chilean universities. The students were tested on their verbal ability, creativity, and insight. A simple linear regression was performed on the complete sample, and on high- and low-achievement groups that were formed based on reading test scores. We observed a significant correlation in the total sample between outcomes on the verbal ability tasks, and on the creativity and insight tasks (range r =. 152 to r =. 356, ps <.001). Scores on the reading comprehension and phonological awareness tasks were the best predictors of performance on creativity and insight tasks (range ß = .315 to ß = .155, ps <.05). A comparison of the low- and high-scoring groups on verbal ability tasks yielded results to the same effect. These findings do not support the hypothesis that specific reading disability is associated with better performance on creative tasks. Instead, higher verbal ability was found to be associated with higher creativity and insight.

Assessment of the behavioral inhibition system and the behavioral approach system: adaptation and validation of the Sensitivity to Punishment and Sensitivity to Reward Questionnaire (SPSRQ) in a Chilean sample.

The goal of the present study is to estimate the psychometric properties of the Sensitivity to Punishment and Sensitivity to Reward Questionnaire (SPSRQ; Torrubia, Avila, Moltó, & Caseras, 2001) in a sample of Chilean college students. The main hypothesis is that the instrument would show appropriate levels of reliability and validity, in light of previous validation studies. A pilot study was conducted in order to generate the adapted version of the questionnaire, which was then applied to a student sample from different undergraduate careers (n = 434). The results show the expected levels of reliability (test-retest and internal consistency). The factorial validity does not comply with the expected model, suggesting a further consideration of the structure of the questionnaire. External validity is appropriate, as the questionnaire shows the expected correlations with other personality measures. It is concluded that the SPSRQ is adequate for the context of validation, and this study contributes to the generalization of the questionnaire, since the results are consistent with the expected psychometric properties that have been reported in the literature.

Assessment of the behavioral inhibition system and the behavioral approach system: adaptation and validation of the sensitivity to punishment and sensitivity to reward questionnaire (SPSRQ) in a chilean sample

The goal of the present study is to estimate the psychometric properties of the Sensitivity to Punishment and Sensitivity to Reward Questionnaire (SPSRQ; Torrubia, Ávila, Moltó, & Caseras, 2001) in a sample of Chilean college students. The main hypothesis is that the instrument would show appropriate levels of reliability and validity, in light of previous validation studies. A pilot study was conducted in order to generate the adapted version of the questionnaire, which was then applied to a student sample from different undergraduate careers (n = 434). The results show the expected levels of reliability (test-retest and internal consistency). The factorial validity does not comply with the expected model, suggesting a further consideration of the structure of the questionnaire. External validity is appropriate, as the questionnaire shows the expected correlations with other personality measures. It is concluded that the SPSRQ is adequate for the context of validation, and this study contributes to the generalization of the questionnaire, since the results are consistent with the expected psychometric properties that have been reported in the literature (AU)

El presente estudio tiene como propósito estimar las propiedades psicométricas del Cuestionario de Sensibilidad al Castigo y Sensibilidad a la Recompensa (SCSR; Torrubia, Ávila, Moltó, y Caseras, 2001) en una muestra de estudiantes chilenos, bajo la hipótesis general de que el instrumento presenta niveles apropiados de fiabilidad y validez, acorde a los estudios previos de validación. Para ello, se condujo inicialmente un estudio piloto que permitió generar la versión adaptada del cuestionario, el cual fue posteriormente aplicado a una muestra definitiva de estudiantes pertenecientes a diferentes carreras universitarias (n = 434). Los resultados muestran los niveles esperados de fiabilidad test-retest y consistencia interna. La validez factorial muestra problemas de ajuste de las escalas según el modelo teórico, sugiriendo una revisión de la estructura del cuestionario. La validez externa, sin embargo, es adecuada y el cuestionario muestra las correlaciones esperadas con otras medidas de personalidad. Se concluye la adecuación del cuestionario SCSR en el contexto de validación y la contribución de este estudio a la generabilidad del instrumento, en tanto los resultados son coherentes con la literatura previa en torno a sus propiedades psicométricas (AU)

ADHD children outperform normal children in an artificial grammar Implicit learning task: ERP and RT evidence.

This study focuses on Implicit learning (IL) in children. One of the main debates in this field concerns the occurrence of IL indicators in experimental settings and its manifestation in different populations. In this research, we are looking for evidence of the occurrence of IL in normal children and in children with Attention Deficit Hyperactive Disorder (ADHD), based on the relationship between accuracy, reaction time and event-related potentials (ERPs). Our results show differences between the analyzed groups with respect to markers for electrophysiological activity and reaction time, but not for accuracy. In consequence, we suggest that research in IL should explore different indicators and their relationship with the cognitive processing levels involved. In addition, IL might involve different forms of information processing in normal children and children with ADHD. We discuss the possible impact of these findings for future research.

Expresión y reconocimiento de emociones: un punto de encuentro entre evolución, psicofisiología y neurociencias / Expression and recognition of emotions: a meeting point for evolution, psychophysiology and neurosciences

El presente artículo presenta una revisión general en relación a la expresión y el reconocimiento de las emociones desde el evolucionismo, la psicofisiología y la neurociencia. Se distingue la función de la expresión y reconocimiento de emociones en un nivel filogenético y la universalidad de dicho fenómeno. Asimismo, se sintetizan los avances más representativos en la caracterización de las emociones desde la tradición psicofisiológica, en particular la actividad del sistema nervioso autónomo y la perspectiva de la autorregulación. Finalmente, se revisan los desarrollos de la neurociencia, que permiten comprender las estructuras involucradas en el reconocimiento y expresión emocional. La discusión se centra en los aportes de cada disciplina y la necesidad de generar una perspectiva que las integre, en vistas a resolver los problemas relacionados con la validez experimental y metodológica del estudio de las emociones.

The current article presents a general revision of research in the expression and recognition of emotions from an evolutionary, psychophysiological, and neuroscientific perspectives. The function of emotional expression and recognition are distinguished according to the phylogeny and universality of this phenomenon. Likewise, the most important approaches characterizing emotions from psychophysiology are synthesized, particularly the autonomous nervous system activity and self-regulation perspectives. Finally, the developments from neuroscience that allow for distinguishing the structures involved in the expression and recognition of emotions are reviewed. The discussion emphasizes the contributions from each discipline, indicating the need for an integrative perspective in order to solve experimental validity issues and methodological challenges in the study of emotions.