RESUMO
The effect of incandescent light treatment on the density of 3H-imipramine binding sites (Bmax) was investigated in 17 patients with seasonal affective disorder, in eight patients with non-seasonal depression and in six healthy volunteers. A significant increase in mean Bmax value parallel to a marked improvement of the depressive symptoms was found only in patients with SAD. No effect was observed either on mean Bmax value or on clinical symptoms in patients with non-SAD and on mean Bmax value in healthy volunteers.
Assuntos
Proteínas de Transporte , Imipramina/farmacocinética , Fototerapia , Receptores de Droga , Receptores de Neurotransmissores/efeitos da radiação , Transtorno Afetivo Sazonal/terapia , Adulto , Idoso , Plaquetas/metabolismo , Plaquetas/efeitos da radiação , Transtorno Depressivo/sangue , Transtorno Depressivo/psicologia , Transtorno Depressivo/terapia , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Escalas de Graduação Psiquiátrica , Receptores de Neurotransmissores/fisiologia , Transtorno Afetivo Sazonal/sangue , Transtorno Afetivo Sazonal/psicologiaRESUMO
The density of platelet 3H-imipramine binding sites (Bmax) was investigated in seven inpatients with winter depression before and after incandescent light treatment and in seven healthy volunteers within a 7-day interval without light exposure. A significantly lower mean Bmax value was found in the depressed patients compared to the controls. After light treatment, parallel to a marked clinical improvement, Bmax increased in each patient and reached or even exceeded the mean values of the controls. These results indicate that in patients with winter depression the decreased Bmax value is state-dependent. The incandescent light treatment has beneficial effect in winter depressives and can influence Bmax values.
