Atovaquone as long-term suppressive therapy for toxoplasmic encephalitis in patients with AIDS and multiple drug intolerance. Atovaquone Expanded Access Group.

OBJECTIVE: To evaluate the efficacy and tolerance of atovaquone used as long-term maintenance therapy in patients with toxoplasmic encephalitis and intolerant of conventional anti-Toxoplasma therapies. DESIGN: Uncontrolled open-label study of atovaquone given through an expanded access programme; statistical analysis was performed on an intent-to-treat basis. PATIENTS: Sixty-five patients intolerant of conventional toxoplasmic encephalitis therapies-pyrimethamine, sulphadiazine or clindamycin-received atovaquone as maintenance therapy after resolution of an acute episode of toxoplasmic encephalitis. Patients were clinically and neurologically evaluated monthly. Toxoplasmic encephalitis relapse was defined as the occurrence of neurological abnormalities, except in the case of a proven alternative diagnosis. RESULTS: Sixty-five patients were treated with atovaquone 750 mg four times daily and followed up for a mean period of 1 year. Mean CD4 lymphocytes count was 29 x 10(6)/l. Prior to starting atovaquone, patients had experienced a total of 129 episodes of intolerance to conventional anti-Toxoplasma drugs. Atovaquone was used as a single anti-toxoplasmic agent in 75% of the cases. Seventeen patients (26%) experienced a toxoplasmic encephalitis relapse. Sixty-three patients (97%) were able to tolerate and continued taking atovaquone. Two patients had to discontinue therapy because of side-effects. In a multivariate analysis, only the duration of pyrimethamine-sulphadiazine therapy during the acute therapy phase of toxoplasmic encephalitis was significantly associated with a decreased risk of toxoplasmic encephalitis relapse during maintenance therapy [relative risk, 0.64 for each week of pyrimethamine-sulphadiazine; 95% confidence interval (CI), 0.42-0.96; P = 0.03]. The survival probability was 70% at 1 year after the episode of toxoplasmic encephalitis (95% CI, 57-83). CONCLUSION: These results suggest that atovaquone is a well-tolerated alternative anti-Toxoplasma treatment for maintenance therapy in patients who are intolerant to conventional anti-Toxoplasma drugs.

El efecto del peróxido de carbamida en gel sobre la capa superficial de una resina compuesta híbrida (Z100-3M) / The effect of carbamide peroxide gel on the surface layer of a hybrid composite resin (Z100-3M)

Esta investigación buscó determinar los efectos sobre la superficie de las resinas compuestas híbridas, colocadas "in vitro", sobre 40 diente naturales, al aplicarles peróxido de carbamina en gel al 10 por ciento y utilizando la técnica de blanqueamiento convencional. Se encontró que la capa superficial de las resinas, tanto del grupo con tratamiento de blanquemiento como el grupo control, observadas bajo microscopio petrográfico, no sufrieron alteraciones en su integridad marginal, ni desintegración. Clínicamente no se observó ningún cambio en el color de la resina misma, teniendo como base la guía de colores de las resinas aplicadas. Se observó bajo el microscopio de luz la existencia de microfiltración marginal en los dientes control y con tratamiento, lo cual puede atribuirse a defectos en la técnica operadora al ser aplicadas las resinas compuestas. Se observó una línea blanca superficial en todas las superficies de los dientes tratados con blanqueamiento