[Pharmaceutical importance of Allium sativum L. 3. Antibacterial effects on Helicobacter pylori]. / Farmaceutický význam Allium sativum L. 3. Antibakteriální úcinek proti Helicobacter pylori.

The paper points out the risk factors which render possible the outbreak of infections due to the bacterium Helicobacter pylori manifesting itself as chronic gastritis. In a great extent it results in peptic and duodenal ulcers and can even lead to the development of adenocarcinoma and lymphoma of the stomach. The paper mentions the efficacy of previous and contemporary therapy. Possible use of garlic in the treatment of these infections is intensively investigated. At present mainly in vitro experiments showing promising results are performed. A minimum of experiments carried out with out-patients produced negative results. As they do not fulfill the parameters of clinical experiments, this question still remains open.

[Atypical mercury poisoning]. / Atypická intoxikácia kovovou ortutou.

A case report documenting rare intravenous intoxication with metal mercury. Because of early diagnosis and treatment only minimal clinical symptoms were detected in the patient.

[Conservative surgical treatment of kidney tumors: indications, techniques, results]. / Konzervativní chirurgická lécba nádoru ledviny: indikace, technika, výsledky.

At the Urological Department in Hradec Králové the authors operated in 1989-1993 287 patients with renal tumours, in 45 of them a conservative procedure was used (15.6%). The group comprises 29 men and 16 women, mean age 56.5 years. The contralateral kidney was normal in 29 patients (64%), in 5 patients nephrectomy was performed on account of carcinoma and in 9 patients (20%) the second kidney was hypofunctional (hydronephrosis, cysts). In two patients a conservative procedure was used on account of malignity of the blood. In 33 patients the tumour was enucleated (73.3%), in 12 the upper or lower pole of the kidney was resected. In 6 patients the tumour was in the first clinical stage, but in four already in T 3a (imperative indication). Twenty-seven tumours were evaluated by the histologist as medium differentiated, 2 of 35 as poorly differentiated. Thirty-five tumours were carcinomas (77.7%), 8 were adenomas, one was angiomyolipoma and in one instance the scar after PEC was removed which was not reliably diagnosed before surgery. The preoperative examination comprised also immunological examination which, however, was not made in two patients. The immunologist evaluated the criteria as favourable in 21 patients (60%), as risky in 12, incl. 6 were immunotherapy was administered. One patient developed a urinous fistula which healed on a stent. During the investigation period no local relapse was observed.

Conservative surgery for renal cell carcinoma--indications, technique and results.

At the Department of urology in Hradec Králové between 1989-1993 287 patients with a tumor of the kidney were operated on, in 45 of them (15.6%) conservatively. In this set there are 29 men and 16 women with the mean age 56.5 years. In 29 patients the contralateral kidney was normal (64%), 5 patients underwent nephrectomy for renal cell carcinoma, in 9 patients the opposite kidney was hypofunctionalised (hydronephrosis, cysts). In two patients the conservative approach was used for reasons of another type of malignancy (haematological). In 33 (73.3%) patients enucleation, in 12 patients resection of the lower or upper pole were done. The tumor was classified as T 1 stage in 6 patients, but in 4 patients already as T 3a (in patients with imperative indication). In 35 patients the tumor was moderately differentiated, in two ones with histologically confirmed renal cell carcinomas the tumors were poorly differentiated, in 8 patients there were histologically adenomas, in one angiomyolipoma and in another case scar after PCN (percutaneous nephrolithotomy). Preoperative examination included immunological examination, this was not done in two patients. Good results were obtained in 21 patients (60%), 12 patients were in high risk and 6 of them received immunotherapy. As an early complication one patient had urinary fistula, which resolved after introduction of stent. Relapse of malignancy in the screening period was not noticed.

Transfer factor and its signification for practice.

In the study literary data are given together with our own experience with the immunomodulation effects of Transfer Factor (TF) Sevac. The application of 3-5 ampulles of TF leads not only to E rosettes but even to a separate subpopulations of T lymphocytes increase. The results obtained in 51 patients with GIT and renal cells carcinoma were statistically evaluated. About 80% of the patients experienced an improvement of subjective conditions during the treatment. Objectively supported adjustment of laboratory indices was found in 83-88% of the parameters evaluated. Also the absolute numbers of CD4+ cells in 10(9)/1 increased (at p < 0.001) together with CD3+ and CD8+ (p < 0.01). A significant correlation between separate subpopulations of T lymphocytes and B lymphocytes was proved in the original mode. From our results it is obvious that the TF Sevac application and further observing of its immunomodulation effect will be the object of interest of the immunologists of general practice and clinical research even in spite of some lacks in its characteristics.

Comparison of direct and indirect migration inhibition tests and skin hypersensitivity to tuberculin (PPD).

The direct macrophage and indirect leukocyte migration inhibition tests were used for the examination of patients with pulmonary tuberculosis and of their contacts. In the direct test at a concentration of 10 microgram PPD/ml medium, a statistically significant difference [p less than or equal to 0.001] was found between the mean values of MI [migration indices] in PPD-negative [MI = 0.98 +/- 0.10] and MI of PPD-positive to patients [MI = 0.60 +/- 0.10]. [PPD-negative = showing no reaction to ID administration of tuberculin, PPD-positive = showing a positive reaction to ID administration of tuberculin]. A statistically significant difference [p less than or equal to 0.05] was also found between the mean values of MI in tuberculin-positive to patients and healthy contacts [MI = 0.80 +/- 0.14]. By means of the indirect test we demonstrated a statistically significant inhibition of migration [p less than or equal to 0.001] in PPD highly positive contacts [MI = 0.76 +/- 0.10]. The results of the direct and indirect migration inhibition tests were found to agree in 66.6%.