The burden of physical inactivity for the public health care system in Brazil.

OBJECTIVE: To update the estimated cost of physical inactivity for the Brazilian Unified Health System (SUS). METHODS: The hospitalization costs were accessed via a database of the Ministry of Health - Informatics Department of the Brazilian SUS. Physical inactivity for the year 2017 was accessed via the Sistema de Vigilância de Fatores de Risco e Proteção para Doenças Crônicas por Inquérito Telefônico (Vigitel - Surveillance System for Risk and Protective Factors for Chronic Diseases by Telephone Survey). Seven chronic non-communicable diseases (NCD) were selected via the international classification of disease (ICD-10). The population fraction attributable to physical inactivity was calculated based on relative risk reported in previous studies and the prevalence of physical inactivity. RESULTS: In 2017, the seven NCD considered in the analysis were responsible for 154,017 hospital admissions in adults older than 40 years old, residing in the state capitals and the Federal District, which corresponded to 6.5% of hospitalizations and 10.6% of SUS costs at an estimated US$ 112,524,914.47. Considering the group of individuals with insufficient physical activity in their leisure time, the percentage cost attributed to physical inactivity reached 17.4% of the estimated costs with NCD. At a national level, NCD were responsible for approximately 740 thousand hospitalizations, costing US$ 482 million, from which 17.4%, US$ 83 million were attributed to physical inactivity. CONCLUSION: This study provides evidence to conclude that physical inactivity exerts an economic impact on the SUS due to NCD hospitalization. Physical inactivity is a modifiable lifestyle and compelling evidence, including that of this article, supports the promotion of a more active community as one of the major targets of public health care policies.

Gender inequalities in violence victimization and depression in Brazil: results from the 2019 national health survey.

BACKGROUND: Violence is a worldwide public health challenge and has been linked to depression in many settings. Depression is higher in women and differential exposure to violence is a potential risk factor - especially in countries with high-levels of violence. This paper provides a comprehensive characterization of the association between violence victimization and depression in Brazil, focusing on sex/gender inequalities. METHODS: We used data from the 2019 wave of the National Health Survey (PNS) in Brazil to assess whether respondents had depression (using PHQ-9) and if they were victims of violence, differentiating by the type of violence, the frequency of victimization, and the primary aggressor. We used logit models to assess the association between victimization and the likelihood of having depression. We predicted probabilities of being depressed, considering the interaction between violence victimization and sex/gender, to analyze the differences between men and women. RESULTS: Rates of violence victimization and depression were higher among women than among men. The odds of being depressed were 3.8 (95%CI: 3.5-4.2) times higher among victims of violence than among non-victims, and 2.3 (95%CI: 2.1-2.6) times higher among women than among men, adjusting for socioeconomic factors. For any given income level, racial/ethnic or age group, victims of violence who were women had the highest predicted probabilities of being depressed - e.g., 29.4% (95%CI: 26.1-32.8) for lower-income women, 28.9% (95%CI: 24.4-33.2) for black women, and 30.4% (95%CI: 25.4-35.4) for younger women that suffered violence. Over one in three women that suffered multiple types of violence, experienced violence more frequently, or where the aggressor was an intimate partner or another family member were predicted to have depression. CONCLUSIONS: Being a victim of violence was strongly associated with higher risk of depression in Brazil, with women more likely to be both victims of violence and develop depression. Frequent, sexual, physical or psychological violence, and intimate partners or family member perpetrators were major risk factors for depression and should be a public health priority.

[The Food and Nutrition Surveillance System (SISVAN) as a tool to monitor the nutritional status of children and adolescents in Brazil]. / O Sistema de Vigilância Alimentar e Nutricional (SISVAN) como ferramenta de monitoramento do estado nutricional de crianças e adolescentes no Brasil.

In Brazil, the Food and Nutrition Surveillance System (SISVAN) is the main tool in collecting and consolidating information on the nutritional status and the feeding habits of the population encompassed by primary health care services of the country. This study explores data from SISVAN to analyze the system's potential as a tool for monitoring the nutritional status of children and adolescents in the country. We seek to evaluate the evolution of the system's coverage rate in relation to the population regarding different age groups and geographic regions, how this coverage rate varies according to the characteristics of the Brazilian municipalities, and to what extent the results from SISVAN differ from representative sample surveys of the population. We present four main results. First, we documented that from 2008 to 2019, SISVAN significantly expanded its coverage; with a significant decrease, however, in 2020, reaching levels similar to those at the beginning of the series. Second, our results indicate that coverage is not homogeneous, being higher in the North and Northeast regions and among underage children. Third, there is a systematic association between the characteristics of the municipalities and the level of coverage of the system. Finally, SISVAN results differ from those presented by surveys representative of the general population. Jointly, the results of this study point to the need to refine the nutritional surveillance instruments on children and adolescents in Brazil.

No Brasil, o Sistema de Vigilância Alimentar e Nutricional (SISVAN) é a ferramenta central para coletar e consolidar informações sobre o estado nutricional e alimentação da população atendida pelos serviços de atenção básica no país. Este trabalho explora dados do SISVAN com o objetivo de analisar o potencial do sistema como ferramenta de monitoramento do estado nutricional de crianças e adolescentes no país. Procura-se avaliar a evolução da taxa de cobertura do sistema em relação à população para diferentes faixas etárias e regiões geográficas, como essa taxa de cobertura varia conforme as características dos municípios brasileiros e em que medida os resultados provenientes do SISVAN diferem de pesquisas amostrais representativas da população. Apresentamos quatro principais resultados. Primeiro, documentamos que, entre 2008 e 2019, o SISVAN expandiu significativamente a sua cobertura, mas houve uma queda expressiva em 2020 até níveis similares aos do início da série. Segundo, nossos resultados apontam que a cobertura não é homogênea, sendo maior nas regiões Norte e Nordeste e entre crianças de menor idade. Terceiro, existe uma associação sistemática entre características dos municípios e o nível de cobertura do sistema. Por último, os resultados do SISVAN divergem dos apresentados por pesquisas representativas da população geral. Em conjunto, os resultados deste estudo apontam para a necessidade de refinar os instrumentos de vigilância nutricional sobre crianças e adolescentes no Brasil.

En Brasil, el Sistema de Vigilancia Alimentaria y Nutricional (SISVAN) es una herramienta clave para recolectar y consolidar información sobre el estado nutricional y la dieta de la población atendida por los servicios de atención primaria en el país. Este trabajo analiza, a partir de los datos de SISVAN, el potencial del sistema como una herramienta de seguimiento del estado nutricional de niños y adolescentes del país. Se pretende evaluar la evolución de la tasa de cobertura del sistema con relación a la población según diferentes grupos de edad y regiones geográficas, cómo varía esta tasa de cobertura según las características de los municipios brasileños y en qué medida los resultados de SISVAN se diferencian de las encuestas por muestreo representativas de la población. Se presentan cuatro resultados principales. Primero, entre 2008 y 2019, SISVAN amplió significativamente su cobertura, pero en 2020 hubo un significativo descenso a niveles similares a los del inicio de la serie. Segundo, los resultados indican que la cobertura no es homogénea, y hay una mayor cobertura en las regiones Norte y Nordeste del país, entre los niños más pequeños. Tercero, existe una asociación sistemática entre las características de los municipios y el nivel de cobertura del sistema. Cuarto, los resultados de SISVAN se diferencian de los presentados en las encuestas representativas de la población general. Los resultados de este estudio apuntan que es necesario mejorar las herramientas de vigilancia nutricional de niños y adolescentes en Brasil.

Inequalities in unmet need for health care services and medications in Brazil: a decomposition analysis.

Background: Unmet need is a metric used to assess the performance of health care systems throughout the world. One of the primary objectives of the Brazilian health care system is to identify ways to improve the health outcomes of all citizens. To accomplish this challenging goal, the health care system in Brazil will need to identify and eliminate barriers and provide timely and adequate access to health care services to all. Methods: This study assessed the performance of the Brazilian health care system by focusing on the unmet need for health care services and medications. We evaluated the Brazilian National Health Survey data collected in 2013 and 2019 to determine the magnitude of socioeconomic-related inequalities associated with unmet health care needs. Primary contributing factors were identified via decomposition analysis of the calculated concentration indices (CInds). Findings: Despite the availability of universal health care, 3.8% and 7.5% of the population in Brazil reported unmet needs for health care services and medications, respectively in the 2019 survey. Although the overall unmet need for medications remained unchanged between 2013 and 2019, CInd analysis revealed significant pro-poor inequalities with respect to unmet needs for both health care services and medications. The overall magnitude of these inequalities was higher in the poorer regions of the country. The use of private health insurance as well as individual health and socioeconomic status contributed significantly to the inequalities associated with unmet needs for health care services and medication throughout Brazil. Interpretations: Policy interventions should focus on improving access to health care services, extending coverage to include pharmaceuticals, and targeting both financial and non-financial barriers to obtaining care, particularly those experienced by the poor and vulnerable populations in Brazil. Funding: None.

Persistent inequalities in health care services utilisation in Brazil (1998-2019).

BACKGROUND: One of the primary objectives of the Brazilian health care system is to improve the health and well-being of all citizens. Since the establishment of the Unified Health System/Sistema Único de Saúde (SUS) in 1988, Brazil has made strides towards reducing inequalities in health care services utilisation. However, there are currently no comprehensive and up-to-date studies focused on inequalities in both curative and preventive health care services utilisation. METHODS: We evaluated data from the National Household Sample Survey and the Brazilian National Health Survey, which are two nationally representative studies that include findings from 1998, 2003, and 2008 and 2013 and 2019, respectively. We calculated Erreygers-corrected Concentration Indices (CInds) to evaluate the magnitude of socioeconomic-related inequalities associated with five indicators of health care services utilisation, including physician visits, hospital admissions, surgical procedures, Pap smears, and mammograms. The main factors associated with these inequalities were identified via a decomposition analysis of the calculated CInds. RESULTS: While the results of our analysis revealed persistent inequalities in health care services utilisation that favour the wealthy, we found that the overall magnitude of these inequalities decreased over time. The largest inequalities were observed in the utilisation of preventive care services (Pap smears and mammograms) and services available in the poorest regions of the country. Except for admissions for labour and delivery, our findings revealed that wealthier individuals were more likely to utilise hospital services; this represents a change from findings reported in previous years. Private health insurance coverage and individual socioeconomic status are significantly associated with inequalities in health care services utilisation throughout Brazil. CONCLUSIONS: Collectively, our findings suggest that we must continue to monitor potential inequalities in health care service utilisation to determine whether Brazilian policy objectives focused on improved health outcomes for all will ultimately be achieved.

The burden of physical inactivity for the public health care system in Brazil

ABSTRACT OBJECTIVE To update the estimated cost of physical inactivity for the Brazilian Unified Health System (SUS). METHODS The hospitalization costs were accessed via a database of the Ministry of Health - Informatics Department of the Brazilian SUS. Physical inactivity for the year 2017 was accessed via the Sistema de Vigilância de Fatores de Risco e Proteção para Doenças Crônicas por Inquérito Telefônico (Vigitel - Surveillance System for Risk and Protective Factors for Chronic Diseases by Telephone Survey). Seven chronic non-communicable diseases (NCD) were selected via the international classification of disease (ICD-10). The population fraction attributable to physical inactivity was calculated based on relative risk reported in previous studies and the prevalence of physical inactivity. RESULTS In 2017, the seven NCD considered in the analysis were responsible for 154,017 hospital admissions in adults older than 40 years old, residing in the state capitals and the Federal District, which corresponded to 6.5% of hospitalizations and 10.6% of SUS costs at an estimated US$ 112,524,914.47. Considering the group of individuals with insufficient physical activity in their leisure time, the percentage cost attributed to physical inactivity reached 17.4% of the estimated costs with NCD. At a national level, NCD were responsible for approximately 740 thousand hospitalizations, costing US$ 482 million, from which 17.4%, US$ 83 million were attributed to physical inactivity. CONCLUSION This study provides evidence to conclude that physical inactivity exerts an economic impact on the SUS due to NCD hospitalization. Physical inactivity is a modifiable lifestyle and compelling evidence, including that of this article, supports the promotion of a more active community as one of the major targets of public health care policies.

O Sistema de Vigilância Alimentar e Nutricional (SISVAN) como ferramenta de monitoramento do estado nutricional de crianças e adolescentes no Brasil / The Food and Nutrition Surveillance System (SISVAN) as a tool to monitor the nutritional status of children and adolescents in Brazil / El Sistema de Vigilancia Alimentaria y Nutricional (SISVAN) como herramienta de seguimiento del estado nutricional de niños y adolescentes en Brasil

No Brasil, o Sistema de Vigilância Alimentar e Nutricional (SISVAN) é a ferramenta central para coletar e consolidar informações sobre o estado nutricional e alimentação da população atendida pelos serviços de atenção básica no país. Este trabalho explora dados do SISVAN com o objetivo de analisar o potencial do sistema como ferramenta de monitoramento do estado nutricional de crianças e adolescentes no país. Procura-se avaliar a evolução da taxa de cobertura do sistema em relação à população para diferentes faixas etárias e regiões geográficas, como essa taxa de cobertura varia conforme as características dos municípios brasileiros e em que medida os resultados provenientes do SISVAN diferem de pesquisas amostrais representativas da população. Apresentamos quatro principais resultados. Primeiro, documentamos que, entre 2008 e 2019, o SISVAN expandiu significativamente a sua cobertura, mas houve uma queda expressiva em 2020 até níveis similares aos do início da série. Segundo, nossos resultados apontam que a cobertura não é homogênea, sendo maior nas regiões Norte e Nordeste e entre crianças de menor idade. Terceiro, existe uma associação sistemática entre características dos municípios e o nível de cobertura do sistema. Por último, os resultados do SISVAN divergem dos apresentados por pesquisas representativas da população geral. Em conjunto, os resultados deste estudo apontam para a necessidade de refinar os instrumentos de vigilância nutricional sobre crianças e adolescentes no Brasil.

In Brazil, the Food and Nutrition Surveillance System (SISVAN) is the main tool in collecting and consolidating information on the nutritional status and the feeding habits of the population encompassed by primary health care services of the country. This study explores data from SISVAN to analyze the system's potential as a tool for monitoring the nutritional status of children and adolescents in the country. We seek to evaluate the evolution of the system's coverage rate in relation to the population regarding different age groups and geographic regions, how this coverage rate varies according to the characteristics of the Brazilian municipalities, and to what extent the results from SISVAN differ from representative sample surveys of the population. We present four main results. First, we documented that from 2008 to 2019, SISVAN significantly expanded its coverage; with a significant decrease, however, in 2020, reaching levels similar to those at the beginning of the series. Second, our results indicate that coverage is not homogeneous, being higher in the North and Northeast regions and among underage children. Third, there is a systematic association between the characteristics of the municipalities and the level of coverage of the system. Finally, SISVAN results differ from those presented by surveys representative of the general population. Jointly, the results of this study point to the need to refine the nutritional surveillance instruments on children and adolescents in Brazil.

En Brasil, el Sistema de Vigilancia Alimentaria y Nutricional (SISVAN) es una herramienta clave para recolectar y consolidar información sobre el estado nutricional y la dieta de la población atendida por los servicios de atención primaria en el país. Este trabajo analiza, a partir de los datos de SISVAN, el potencial del sistema como una herramienta de seguimiento del estado nutricional de niños y adolescentes del país. Se pretende evaluar la evolución de la tasa de cobertura del sistema con relación a la población según diferentes grupos de edad y regiones geográficas, cómo varía esta tasa de cobertura según las características de los municipios brasileños y en qué medida los resultados de SISVAN se diferencian de las encuestas por muestreo representativas de la población. Se presentan cuatro resultados principales. Primero, entre 2008 y 2019, SISVAN amplió significativamente su cobertura, pero en 2020 hubo un significativo descenso a niveles similares a los del inicio de la serie. Segundo, los resultados indican que la cobertura no es homogénea, y hay una mayor cobertura en las regiones Norte y Nordeste del país, entre los niños más pequeños. Tercero, existe una asociación sistemática entre las características de los municipios y el nivel de cobertura del sistema. Cuarto, los resultados de SISVAN se diferencian de los presentados en las encuestas representativas de la población general. Los resultados de este estudio apuntan que es necesario mejorar las herramientas de vigilancia nutricional de niños y adolescentes en Brasil.

Socioeconomic and racial/ethnic inequalities in depression prevalence and the treatment gap in Brazil: A decomposition analysis.

Depression is a major global health burden and there are stark socioeconomic inequalities in both the prevalence of depression and access to treatment for depression. In Brazil, racial/ethnic inequalities are of particular concern, but the factors contributing to these inequalities remain mostly unknown. This paper firstly explores determinants of depression and the treatment gap (i.e., untreated afflicted individuals) in Brazil and identifies if socio-economic and health system factors explain changes over time. Secondly, it analyses income and racial/ethnic inequalities in depression and the treatment gap and identifies factors explaining inequalities through decomposition methods. Data from two waves (2013 and 2019) of a representative household-based survey are used. In 2019, 10.8% of adults were depressed, but over 70% of depressed adults did not receive care. Black or brown/mixed Brazilians were more likely to have untreated depression, and region of residence was the most important determinant of these racial/ethnic inequalities. Notably, 44.6% of the difference in the treatment gap between white individuals and black and brown/mixed individuals was not explained by differences in observables, which could potentially be due to discrimination or difficulties in accessing treatment due to other non-observable characteristics. Employment, age, exposure to violence and physical activity are the main contributing factors to income inequalities in depression. These results suggest that policies aimed at improving the levels of exposure of lower-income individuals to risk factors may positively impact mental health and mental health inequalities, while addressing inequalities in service provision and resourcing for mental health and tackling barriers to access stemming from discrimination are essential to bridge the treatment gap equitably.

Inequalities in the prevalence of cardiovascular disease risk factors in Brazilian slum populations: A cross-sectional study.

BACKGROUND: Social and environmental risk factors in informal settlements and slums may contribute to increased risk of cardiovascular disease (CVD). This study assesses the socioeconomic inequalities in CVD risk factors in Brazil comparing slum and non-slum populations. METHODS: Responses from 94,114 individuals from the 2019 Brazilian National Health Survey were analysed. The United Nations Human Settlements Programme definition of a slum was used to identify slum inhabitants. Six behavioural risk factors, four metabolic risk factors and doctor-diagnosed CVD were analysed using Poisson regression models adjusting for socioeconomic characteristics. RESULTS: Compared to urban non-slum inhabitants, slum inhabitants were more likely to: have low (less than five days per week) consumption of fruits (APR: 1.04, 95%CI 1.01-1.07) or vegetables (APR: 1.08, 95%CI 1.05-1.12); drink four or more alcoholic drinks per day (APR: 1.05, 95%CI 1.03-1.06); and be physically active less than 150 minutes per week (APR: 1.03, 95%CI 1.01-1.04). There were no differences in the likelihoods of doctor-diagnosed metabolic risk factors or CVD between the two groups in adjusted models. There was a higher likelihood of behavioural and metabolic risk factors among those with lower education, with lower incomes, and the non-White population. CONCLUSIONS: Brazilians living in slums are at higher risk of behavioural risk factors for CVD, suggesting local environments might impact access to and uptake of healthy behaviours.

Inequalities in the prevalence of major depressive disorder in Brazilian slum populations: a cross-sectional analysis.

AIMS: The mental health of slum residents is under-researched globally, and depression is a significant source of worldwide morbidity. Brazil's large slum-dwelling population is often considered part of a general urban-poor demographic. This study aims to identify the prevalence and distribution of depression in Brazil and compare mental health inequalities between slum and non-slum populations. METHODS: Data were obtained from Brazil's 2019 National Health Survey. Slum residence was defined based on the UN-Habitat definition for slums and estimated from survey responses. Doctor-diagnosed depression, Patient Health Questionnaire (PHQ-9)-screened depression and presence of undiagnosed depression (PHQ-9-screened depression in the absence of a doctor's diagnosis) were analysed as primary outcomes, alongside depressive symptom severity as a secondary outcome. Prevalence estimates for all outcomes were calculated. Multivariable logistic regression models were used to investigate the association of socioeconomic characteristics, including slum residence, with primary outcomes. Depressive symptom severity was analysed using generalised ordinal logistic regression. RESULTS: Nationally, the prevalence of doctor diagnosed, PHQ-9 screened and undiagnosed depression were 9.9% (95% confidence interval (CI): 9.5-10.3), 10.8% (95% CI: 10.4-11.2) and 6.9% (95% CI: 6.6-7.2), respectively. Slum residents exhibited lower levels of doctor-diagnosed depression than non-slum urban residents (8.6%; 95% CI: 7.9-9.3 v. 10.7%; 95% CI: 10.2-11.2), while reporting similar levels of PHQ-9-screened depression (11.3%; 95% CI: 10.4-12.1 v. 11.3%; 95% CI: 10.8-11.8). In adjusted regression models, slum residence was associated with a lower likelihood of doctor diagnosed (adjusted odds ratio (adjusted OR): 0.87; 95% CI: 0.77-0.97) and PHQ-9-screened depression (adjusted OR: 0.87; 95% CI: 0.78-0.97). Slum residents showed a greater likelihood of reporting less severe depressive symptoms. There were significant ethnic/racial disparities in the likelihood of reporting doctor-diagnosed depression. Black individuals were less likely to report doctor-diagnosed depression (adjusted OR: 0.66; 95% CI: 0.57-0.75) than white individuals. A similar pattern was observed in Mixed Black (adjusted OR: 0.72; 95% CI: 0.66-0.79) and other (adjusted OR: 0.63; 95% CI: 0.45-0.88) ethnic/racial groups. Slum residents self-reporting a diagnosis of one or more chronic non-communicable diseases had greater odds of exhibiting all three primary depression outcomes. CONCLUSIONS: Substantial inequalities characterise the distribution of depression in Brazil including in slum settings. People living in slums may have lower diagnosed rates of depression than non-slum urban residents. Understanding the mechanisms behind the discrepancy in depression diagnosis between slum and non-slum populations is important to inform health policy in Brazil, including in addressing potential gaps in access to mental healthcare.

The quality of alternative models of primary health care and morbidity and mortality in Brazil: a national longitudinal analysis.

Background: Evidence is limited on health benefits from quality improvement of primary healthcare (PHC) in low- and middle-income countries (LMICs). This study investigated whether increasing PHC quality in Brazil with highly-skilled health professionals and integrated community health workers (CHWs) was associated with reductions in hospitalizations and mortality beyond benefits derived from increasing access. Methods: Annual municipal-level data for 5,411 municipalities between 2000 and 2014 were analysed using fixed effects panel regressions. PHC quality was measured as: i) the proportion of consultations provided by highly-skilled health professionals (doctors and nurses); and ii) the proportion of visits provided by CHWs from multidisciplinary PHC teams. Models assessed associations between PHC quality and hospitalization and mortality from diabetes, cardiovascular disease (CVD), tuberculosis, leprosy, perinatal and maternal causes, and adjusted for PHC access, utilisation, presence of secondary care services, and socioeconomic factors. Findings: A one percentage point increase in the proportion of consultations provided by highly-skilled health professionals was associated with 0•019 fewer deaths from diabetes per 100,000 population (95%CI: -0•034, -0•003; p-value: 0.0167) and 0•029 fewer hospitalizations per 100,000 from leprosy (95%CI: -0•055, -0•002; p-value: 0.0321). A one percentage point increase in the proportion of care provided by CHWs from multidisciplinary PHC teams was associated with 0•025 fewer deaths from CVD per 100,000 (95%CI: -0•050, -0•001; p-value: 0.0442) and 0•148 fewer maternal hospital admissions per 100,000 (95%CI: -0•286, -0•010; p-value: 0.0356). No significant associations were found for the other twenty pairs of exposures and outcomes analysed. Interpretation: Investing in higher-quality PHC models with highly-skilled health professionals and integrated CHWs can deliver reductions in mortality and hospitalizations in LMICs. Funding: None.

Environmental disasters and birth outcomes: Impact of a tailings dam breakage in Brazil.

There is evidence of a relationship between in utero exposure to catastrophic events and adverse birth outcomes, usually attributed to heightened maternal stress. The objective of our work was to evaluate if the breakage of a dam containing wastefrom a mining cite in Brazil, in 2015, an environmental disaster popularly known as the Mariana Tragedy, affected the health of newborns exposed in utero. We used administrative data on birth records and reports on the Mariana Tragedy to identify all births from newborns exposed in utero and the intensity of that exposure, according to the mother's municipality of residence. Using a difference-in-differences framework, we estimated the impact of different intensities of exposure on birth outcomes. We found that being directly exposed in utero to the Tragedy resulted in 1.86 days shorter gestational age and 2.6 percentage points higher incidence of preterm birth (<37 weeks). We found no impact on birthweight related outcomes. The effect is larger than previously identified for other catastrophic events. We hypothesize that this is probably due to the Tragedy impacting birth outcomes not exclusively through heightened maternal stress, but also through depressed economic activity in directly affected municipalities.

In utero exposure to economic fluctuations and birth outcomes: An analysis of the relevance of the local unemployment rate in Brazilian state capitals.

OBJECTIVE: Analyze if in utero exposure to economic downturns is associated with worsened birth outcomes. METHODS: We used birth records from all live singleton births in the 27 Brazilian state capitals between October 2012 and December 2016 (n = 2,952,430) and linked them to local unemployment rates according to the mother's residence. We estimated the association between different birth outcomes and the local unemployment rate in the three trimesters before birth. We included maternal characteristics and month, year and municipality fixed effects as covariates. We also estimated the association for different groups of mothers, based on marital status, educational level, age and race. RESULTS: A 1 p.p. increase in the local unemployment rate in the trimester before birth is associated with 2.68% higher odds of being born with very low birthweight (< 1500 grams) (OR: 1.0268, 95% CI: 1.0006-1.0536). That result is pushed by the effect among newborns from mothers younger than 24 (OR: 1.0684, 95%CI: 1.0353-1.1024), from mothers with 11 years of schooling or less (OR: 1.0477, 95% CI: 1.0245-1.0714), and from brown or black mothers (OR: 1.0387, 95%CI: 1.0156-1.0624). The associations among children born from younger, less educated and black or brown mothers are robust to the application of a procedure to control for multiple testing, albeit the results considering the whole sample are not. CONCLUSIONS: Our study shows that there is an association between in utero exposure to higher unemployment rates during the last gestational trimester and the odds of being born with VLBW among children born from mothers younger than 24 years old, with less of 11 years of education and black or brown. These results suggest that children born from women of low socioeconomic status are more vulnerable to in utero exposure to economic downturns.