RESUMO
Polymorphism of the acetylation and oxidation phenotypes in patients with IDDM was evaluated. A greater statistically significant number of fast acetylators in IDDM was found.
Assuntos
Diabetes Mellitus Tipo 1/genética , Diabetes Mellitus Tipo 1/metabolismo , Acetilação , Adulto , Feminino , Humanos , Masculino , Oxirredução , Fenótipo , Polimorfismo GenéticoRESUMO
Alloxan is a well-known and universally used agent for evoking experimental diabetes through its toxic effect on the B cells of the Langerhans islets. In our study, blood levels of alloxan in children with insulin-dependent diabetes mellitus were investigated. The observations were made in 68 children aged 6-15 years and in a control group of 44 healthy children in the same age range. Alloxan levels were estimated spectrophotometrically. The mean level of alloxan in blood from children with insulin-dependent diabetes mellitus was 8.76 +/- 9.64 micrograms/ml and in blood from healthy children was 1.53 +/- 1.10 micrograms/ml. The difference was statistically significant (P < 0.05). The metabolism of alloxan leads to the production of free superoxide radicals which, as is well known, injure cells and cause conditions conducive to the occurrence of diseases from autoimmunity. The results obtained suggest therefore that higher levels of alloxan in diabetic children are of significance in the onset of insulin-dependent diabetes mellitus.
Assuntos
Aloxano/sangue , Diabetes Mellitus Tipo 1/sangue , Adolescente , Estudos de Casos e Controles , Criança , Radicais Livres/sangue , HumanosRESUMO
Serum pancreatic polypeptide (hPP) concentrations ranged in normal children from 45 pg/ml to 525 pg/ml with mean value at 185 +/- 49 pg/ml. Both hPP and glucagon immunoreactivity (IRG) levels showed age-dependent decrease during childhood. In diabetic children plasma IRG concentrations were significantly increased in comparison with the healthy subjects while hPP concentrations were only slightly elevated. The age dependence of the hormones levels was completely effaced in diabetics. No significant serum hPP norm IRG values dependence on the duration of diabetes was found. IRG/hPP relations correlated with age in healthy children despite those in diabetic ones.
Assuntos
Diabetes Mellitus Tipo 1/sangue , Glucagon/sangue , Polipeptídeo Pancreático/sangue , Adolescente , Envelhecimento/sangue , Criança , Pré-Escolar , Diabetes Mellitus Tipo 1/tratamento farmacológico , Jejum , Humanos , Lactente , Insulina/uso terapêutico , RadioimunoensaioAssuntos
Esôfago , Corpos Estranhos/diagnóstico , Criança , Corpos Estranhos/cirurgia , Humanos , Masculino , Fatores de TempoAssuntos
Adenosina Desaminase/sangue , Nucleosídeo Desaminases/sangue , Diester Fosfórico Hidrolases/sangue , Adolescente , Bronquite/enzimologia , Criança , Pré-Escolar , Fibrose Cística/enzimologia , Doenças Hematológicas/enzimologia , Humanos , Lactente , Síndromes de Malabsorção/enzimologia , Pneumonia/enzimologia , Febre Reumática/enzimologiaAssuntos
Cobre/sangue , Ferro/sangue , Pneumonia/sangue , Tonsilite/sangue , Ceruloplasmina/análise , Criança , Feminino , Humanos , Masculino , Transferrina/análiseAssuntos
Bronquite/complicações , Candidíase/complicações , Hemossiderose/complicações , Pneumopatias/complicações , Traqueíte/complicações , Bronquite/diagnóstico , Candidíase/diagnóstico , Pré-Escolar , Hemossiderose/diagnóstico , Humanos , Pneumopatias/diagnóstico , Masculino , Traqueíte/diagnósticoRESUMO
In the experiments on adrenalectomized animals it was shown that the fever-associated rise in the blood copper level was absent in these animals. Hydrocortisone administration to adrenalectomized animals restored the normal reactivity of the animals to injections of pyrogens.
