RESUMO
Formylation of ansa[4]-ferrocene, obtained through the ruthenium-catalysed olefin metathesis, yields two separable, planar chiral 1,3- and 1,2-ansa-ferrocene aldehydes. Single-crystal X-ray structure analysis reveals that both regioisomers crystallize with spontaneous resolution of the racemate in the chiral P212121 space group with one molecule in the asymmetric unit. The major 1,3-isomer was further transformed into a conjugate with 1,2,3-triazole and uracil using "click" chemistry as the key synthetic step. This inorganic-organic hybrid displays anticancer activity (MCF-7, A549, MDA-MB-231 cell lines) with EC50 values comparable to those for cisplatin.
Assuntos
Antineoplásicos/síntese química , Complexos de Coordenação/síntese química , Compostos Ferrosos/síntese química , Metalocenos/síntese química , Aldeídos/química , Alcenos/química , Antineoplásicos/farmacologia , Apoptose/efeitos dos fármacos , Catálise , Linhagem Celular Tumoral , Proliferação de Células/efeitos dos fármacos , Química Click , Complexos de Coordenação/farmacologia , Desenvolvimento de Medicamentos , Compostos Ferrosos/farmacologia , Humanos , Isomerismo , Metalocenos/farmacologia , Rutênio/química , Relação Estrutura-Atividade , Triazóis/químicaRESUMO
Total synthesis of levetiracetam, an active ingredient of epilepsy treatment medications, is reported. The reported method is based on a one-pot dehydration/sigmatropic rearrangement of (R,E)-hept-4-en-3-ol carbamate to the corresponding allylamine derivative, an advanced precursor of levetiracetam.