Local weather phenomenon Galerna influences daily radon concentrations in northern Iberian Peninsula.

One of the main factors that affect urban air quality is meteorology. The objective of this study is to understand and characterise the influence that "Galerna" (GL) (an abrupt westerly change over the northern coast of Spain) has on the daily variability of the air quality over Bilbao city (northern Spain). A total of 46 one-day periods from 2009 to 2019 during which GL have been analysed. Radon observations at the Bilbao city radiological station were used because radon is a suitable atmospheric tracer by which to assess and characterise air quality dynamics. The cluster analysis of these periods revealed that increases in radon concentrations, mainly in the afternoon, are associated with the occurrence of GL, but that, this increase in the daily variability of radon concentrations in Bilbao is not reflected in all these GL periods. This variability in the impact of the GL scenario on radon concentrations is associated with the location of Bilbao: along the Nervion valley and 16 km from the coast. The analysis of three GL periods using 10-min surface meteorological and radon data showed an anomalous increase in radon with the arrival of maritime winds, which is associated with the process of a progressive accumulation of radon concentrations over the coastal area in the previous days, and the displacement of these air masses inland owing to the development of the GL event. Our results consequently identify the impact of GL on urban air quality in the afternoon, along with the fact that the complex layout of this coastal area, with the presence of valleys and mountains, favours the formation of reservoir layers above the coastal and valley areas, thus influencing on daily variability of air pollution concentrations. These increases in radon concentrations do not present a significant impact on human health.

A case of possible transfusion-acquired malaria in Zaragoza, Spain.

We present the case of a 75-year-old patient diagnosed with malaria, a native of Zaragoza, Spain, despite having no travel history to malaria-endemic regions. Following an extensive investigation, transfusion emerged as the most probable mode of transmission.

A 14-year review (2007-2020) of helminthiasis epidemiology in a hospital in Southern Madrid, Spain.

PURPOSE: Vast majority of helminth diseases remain neglected tropical diseases (NTDs), causing significant morbidity. The widespread and periodic distribution of antiparasitic drugs, remains the cornerstone for controlling these diseases. In Spain, most helminthiasis cases are imported, and suspicion and diagnosis have become increasingly important. Our primary objective is to present the epidemiological landscape of helminthiasis diagnoses within our facility, while also detailing the demographic characteristics of the affected population. METHODS: A retrospective study was conducted at the Hospital Universitario Severo Ochoa (HUSO) from January 1, 2007, to December 31, 2020, encompassing all diagnosed cases of helminthiasis during this period. Comprehensive epidemiological, clinical, and microbiological data were gathered for all diagnosed patients. The study population comprised patients receiving treatment at the HUSO, as well as those receiving treatment at the Leganés and Fuenlabrada Primary Care Units. Subsequently, descriptive and comparative statistics were performed, comparing Spanish and foreign patients. RESULTS: During this period, a total of 952 patients were diagnosed with some form of helminthiasis. Among them, 495 were Spanish, and 457 were foreign. The total number of helminths identified, including patients with multiple infections, was 1,010. Significant differences were observed between Africans and Americans in terms of age distribution, with a higher prevalence among Africans in the 0-15 age range and among Americans in the 31-60 age range. Variations were noted in the distribution of helminths, with S. stercoralis significantly affecting Americans. For Spanish patients, the presence of Trichuris trichiura and S. stercoralis was significantly associated with eosinophilia, whereas among foreign patients, it was associated with Trichuris trichiura, Ascaris lumbricoides among others. Regarding symptoms, skin manifestations were more frequent among Spanish, while digestive were more common among foreigners. CONCLUSIONS: This study offers crucial epidemiological insights into helminth infections observed over time in a Madrid hospital. Although the prevalence of helminth infections has been decreasing, there is still a need for screening and diagnosing foreign patients.

Analysis of 222Rn Surface Concentrations in the Basque Country (Spain): A Case Study of Heat Waves.

The objective of this study was to characterize radon concentrations registered in the Radiological Surveillance Network of the Basque country in relation to local meteorological parameters, and to determine its behaviour under heatwave events. For this purpose, radon measurements and meteorological parameters from June 2012 to June 2015 were analysed at two sites, Bilbao and Vitoria (northern Spain), in a region characterized by complex orography, causing large temporal and spatial variability in meteorological conditions. Yearly, seasonal, and diurnal cycle differences and similarities were investigated at both sites. The temporal evolution of radon concentration was analysed at both sites during the two heatwave periods officially identified by the State Meteorological Agency (8-11 August 2012 and 17-23 August 2012). The analysis revealed two different patterns of radon concentrations, in terms of both time and intensity, under this synoptic pattern, making it also possible to identify regional transport channels of radon concentrations between the two sites. This set of results evidences the adequate position of both stations to represent the spatial and temporal evolution of radiological variables continuously in this region.

Meteorological Approach in the Identification of Local and Remote Potential Sources of Radon: An Example in Northern Iberian Peninsula.

This paper presents a meteorological approach to identify local and remote sources driving the variability of surface daily radon concentrations. To this purpose, hourly 222Rn concentration and surface meteorological measurements, and air mass trajectories at Bilbao station (northern Iberian Peninsula) during the period 2017-2018 have been taken as reference. To investigate the potential transport pathways and potential 222Rn sources, the backward trajectory cluster analysis, trajectory sector analysis (TSA), and potential source contribution function (PSCF) are applied. On average, the diurnal 222Rn cycle shows the expected behaviour, with larger concentrations during the night and minimum concentrations during the daylight hours, with differences in the seasonal amplitudes. According to daily differences between maximum and baseline values, 222Rn daily cycles were grouped into six groups to identify meteorological conditions associated with each amplitude, and potential source areas and transport routes of 222Rn over Bilbao. The trajectory cluster and the TSA method show that the main airflow pathways are from the south, with small displacement, and the northeast, while the analysis of surface wind speed and direction indicates that the highest amplitudes of 222Rn concentrations are registered under the development of sea-land breezes. The PSCF method identified south-western and north-eastern areas highly contributing to the 222Rn concentration. These areas are confirmed by comparing with the radon flux map and the European map of uranium concentration in soil. The results have demonstrated the need in combining the analysis of local and regional/synoptic factors in explaining the origin and variability of 222Rn concentrations.

Deep Sequencing Reveals Occult Mansonellosis Coinfections in Residents From the Brazilian Amazon Village of São Gabriel da Cachoeira.

Mansonella ozzardi and Mansonella perstans infections both cause mansonellosis but are usually treated differently. Using a real-time polymerase chain reaction assay and deep sequencing, we reveal the presence of mansonellosis coinfections that were undetectable by standard diagnostic methods. Our results confirm mansonellosis coinfections and have important implications for the disease's treatment and diagnosis.

Prospective comparative multi-centre study on imported Plasmodium ovale wallikeri and Plasmodium ovale curtisi infections.

BACKGROUND: Few previous retrospective studies suggest that Plasmodium ovale wallikeri seems to have a longer latency period and produces deeper thrombocytopaenia than Plasmodium ovale curtisi. Prospective studies were warranted to better assess interspecies differences. METHODS: Patients with imported P. ovale spp. infection diagnosed by thick or thin film, rapid diagnostic test (RDT) or polymerase chain reaction (PCR) were recruited between March 2014 and May 2017. All were confirmed by DNA isolation and classified as P. o. curtisi or P. o. wallikeri using partial sequencing of the ssrRNA gene. Epidemiological, analytical and clinical differences were analysed by statistical methods. RESULTS: A total of 79 samples (35 P. o. curtisi and 44 P. o. wallikeri) were correctly genotyped. Males predominate in wallikeri group (72.7%), whereas were 48.6% in curtisi group. Conversely, 74.3% of curtisi group were from patients of African ethnicity, whilst 52.3% of Caucasians were infected by P. o. wallikeri. After performing a multivariate analysis, more thrombocytopaenic patients (p = 0.022), a lower number of platelets (p = 0.015), a higher INR value (p = 0.041), and shorter latency in Caucasians (p = 0.034) were significantly seen in P. o. wallikeri. RDT sensitivity was 26.1% in P. o. curtisi and 42.4% in P. o. wallikeri. Nearly 20% of both species were diagnosed only by PCR. Total bilirubin over 3 mg/dL was found in three wallikeri cases. Two patients with curtisi infection had haemoglobin under 7 g/dL, one of them also with icterus. A wallikeri patient suffered from haemophagocytosis. Chemoprophylaxis failed in 14.8% and 35% of curtisi and wallikeri patients, respectively. All treated patients with various anti-malarials which included artesunate recovered. Diabetes mellitus was described in 5 patients (6.32%), 4 patients of wallikeri group and 1 curtisi. CONCLUSIONS: Imported P. o. wallikeri infection may be more frequent in males and Caucasians. Malaria caused by P. o. wallikeri produces more thrombocytopaenia, a higher INR and shorter latency in Caucasians and suggests a more pathogenic species. Severe cases can be seen in both species. Chemoprophylaxis seems less effective in P. ovale spp. infection than in P. falciparum, but any anti-malarial drug is effective as initial treatment. Diabetes mellitus could be a risk factor for P. ovale spp. infection.

Comparison of imported Plasmodium ovale curtisi and P. ovale wallikeri infections among patients in Spain, 2005-2011.

Sequencing data from Plasmodium ovale genotypes co-circulating in multiple countries support the hypothesis that P. ovale curtisi and P. ovale wallikeri are 2 separate species. We conducted a multicenter, retrospective, comparative study in Spain of 21 patients who had imported P. ovale curtisi infections and 14 who had imported P. ovale wallikeri infections confirmed by PCR and gene sequencing during June 2005-December 2011. The only significant finding was more severe thrombocytopenia among patients with P. ovale wallikeri infection than among those with P. ovale curtisi infection (p = 0.031). However, we also found nonsignificant trends showing that patients with P. ovale wallikeri infection had shorter time from arrival in Spain to onset of symptoms, lower level of albumin, higher median maximum core temperature, and more markers of hemolysis than did those with P. ovale curtisi infection. Larger, prospective studies are needed to confirm these findings.

[Biodefense: a new challenge for microbiology and public health]. / Biodefensa: un nuevo desafío para la microbiología y la salud pública.

Bioterrorism and the potential use of biological weapons has become an important concern of governments and responsible authorities. An example of this threat occurred in 2001 in the USA, when letters were sent containing spores of the agent that produces anthrax; this resulted in some deaths, and caused panic and negative effects on the world economy. If this small-scale event was able to cause such a huge impact, the repercussions of a massive attack could be catastrophic. In many countries, these events have resulted in the implementation of measures directed toward preventing and responding to bioterrorist threats and acts. As a whole, these measures are known as biodefense. This article briefly analyzes several aspects related to detecting and identifying acts of bioterrorism, and considers the biological agents that are implicated. The microbiological diagnosis that allows identification of the causal agent, a key point for taking suitable control measures, is also included.

Biodefensa: un nuevo desafío para la microbiología y la salud pública / Biodefense: a new challenge for microbiology and public health

El bioterrorismo y el uso potencial de armas biológicas se ha convertido en una preocupación importante de los gobiernos y autoridades competentes. Como ejemplo, el envío de cartas con esporas del agente causante del carbunco en Estados Unidos en 2001 ocasionó varias muertes, causó pánico y tuvo repercusiones negativas en la economía mundial. Si este incidente, a pequeña escala, produjo semejante impacto, los efectos de un ataque masivo podrían ser catastróficos. En muchos países éste fue el punto que marcó el inicio de la toma de medidas encaminadas a prevenir y responder ante amenazas y actos bioterroristas, acciones que, en su conjunto, se conocen como biodefensa. Este artículo pretende analizar someramente algunos aspectos relacionados con la detección e identificación de este tipo de acciones y los agentes biológicos implicados. Se considera el diagnóstico microbiológico que permite la identificación del agente causal, punto clave para la toma de medidas de control adecuadas (AU)

Bioterrorism and the potential use of biological weapons has become an important concern of governments and responsible authorities. An example of this threat occurred in 2001 in the USA, when letters were sent containing spores of the agent that produces anthrax; this resulted in some deaths, and caused panic and negative effects on the world economy. If this small-scale event was able to cause such a huge impact, the repercussions of a massive attack could be catastrophic. In many countries, these events have resulted in the implementation of measures directed toward preventing and responding to bioterrorist threats and acts. As a whole, these measures are known as biodefense. This article briefly analyzes several aspects related to detecting and identifying acts of bioterrorism, and considers the biological agents that are implicated. The microbiological diagnosis that allows identification of the causal agent, a key point for taking suitable control measures, is also included (AU)

Proyecto de comunicación en salud Por una Vida Bien Plantada: Modelo metodológico de la estrategia de intervención con la comunicación social: factor de riesgo, agresión y violencia / Health communication project Good Life Planned: methodological model of the intervention strategy with social communication :risk factor, aggression and violence

El Departamento de Caldas y en particular la ciudad de Manizales han hecho importantes esfuerzos para lograr una mejor atención en salud de su población estableciendo procesos de descentralización, integración funcional, intersectorialidad, participación ciudadana, campañas de prevención y propiciando la atención primaria en programas comunitarios que benefician los diferentes grupos etáreos de la población. Los esfuerzos anteriores han pérmitido principalmente una mayor cobertura de atención y una mayor provisión de servicios asistenciales predominando el énfasis del componente biomédico y el aspecto curativo de la salud, sobre las acciones de prevención y promoción. La ausencia de estudios cualitativos en la región que informen acerca de los comportamientos de las personas frente a los factores de riesgo que afectan la salud de la comunidad, ha impedido la estructuración lógica y coherente de programas promocionales integrados que respondan a las características de la población, dentro de un contexto participativo, originados, discutidos y reafirmados en la comunidad. La importancia de esta investigación se basa precisamente en la adquisición de la información sobre los conocimientos, creencias, percepciones, actitudes y prácticas de nuestra población frente a la agresión y violencia, tabaquismo y alcoholismo y accidentalidad; al igual que las preferencias por los medios de comunicación para recibir información y educación en salud

Eficacia de la ensenanza de las ciencias medicas: persistencia de los conocimientos en internos y residentes / Efficacy of teaching medical sciences: persistence of knowledge in interns and residents

En este estudio se busco establecer: a) La eficacia de la ensenanza de las ciencias clinicas medicas, medida por el aumento relativo de conocimientos de los estudiantes entre dos evaluaciones, una al comienzo y otra al final de los cursos, y b ) El grado de retencion de conocimientos de ciencias clinicas en internos y residentes, evaluado con los mismos cuestionarios utilizados en el caso anterior. Con respecto al primer objetivo, en todos los cursos, con una sola excepcion, hubo un aumento material y estadisticamente significativo de los conocimientos, pero el promedio global de conocimientos "reales" fue 40.7%, que se considera bajo; ademas, los resultados muestran que el nivel de conocimientos al final de los cursos no esta en relacion directa con la eficacia del proceso de ensananza-aprendizaje. En cuanto al segundo objetivo, se encontro que los conocimientos de los internos y residentes en varias ciencias clinicas eran significativamente menores que los de los estudiantes al finalizar los cursos. Este estudio pone de manifiesto la importancia de evaluar comparativamente los conocimientos de los estudiantes de medicina en ciencias clinicas al comienzo y al final de los cursos.

Analgesia con morfina por via epidural / Morphine analgesia by epidural way

Se evalúo la analgesia con Morfina epidural en 53 pacientes sometidos a cirugía de abdómen alto, abdómen bajo y dolor crónico, utilizando dosis de 4,3 y 2 mgrs. respectivamente, comprobándose la obtención de analgesia de iniciación rápida y de acción muy prolongada. En el primer grupo se valoró la función respiratoria obteniéndose mejoría después de la analgesia. Se observó que la ambulación y movilidad de los pacientes se produjo muy rápidamente en el postoperatório. Los efectos indeseables fueron muy escasos concluyendo que este método es muy efectivo, seguro y exento de complicaciones peligrosas en el manejo del dolor postoperatório y crónico