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Proc Soc Exp Biol Med ; 196(3): 301-6, 1991 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-1998007

RESUMO

Progesterone (P), a major hormone of pregnancy, was selected for study under the conditions of an intact utero-placental-fetal unit. A preparation of the canine gravid uterus, near term, is described and shown to permit observation of the metabolic relationships of the steroid hormone P between maternal and fetal organisms. [1,2-3H] P or [7 alpha-3H]P was injected into pups, while [4-14C]P was injected into the uterine circulation. Perfusion was continued for 1 hr with excellent survival of the pups. Identified metabolites in the fetal and maternal tissues suggest a metabolic pool that is shared throughout the unit.


Assuntos
Feto/metabolismo , Placenta/metabolismo , Progesterona/metabolismo , Animais , Encéfalo/metabolismo , Cromatografia Gasosa , Cromatografia Líquida de Alta Pressão , Cães , Feminino , Mucosa Intestinal/metabolismo , Fígado/metabolismo , Pulmão/metabolismo , Troca Materno-Fetal , Gravidez , Útero/metabolismo
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