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1.
Nat Prod Res ; : 1-9, 2024 Jan 17.
Artigo em Inglês | MEDLINE | ID: mdl-38230507

RESUMO

Xanthorrhizol (1) is known as the major terpenoid component of the rhizome of Curcuma xanthorrhiza and having some interesting biological activities. In this report, we synthesised five derivatives of 1 containing nitrogen-functional groups. Four of them are new synthesised compounds, including (R)-4-(3-(2-methyl-5-(6-methylhept-5-en-2-yl)phenoxy)propyl)morpholine (2), (R)-N-benzyl-3-(2-methyl-5-(6-methylhept-5-en-2-yl)phenoxy)propan-1-amine (3), (R)-6,7-dimethoxy-3-(3-(2-methyl-5-(6-methylhept-5-en-2-yl)phenoxy)propyl)quinazolin-4(3H)-one (4), and (R)-6-methyl-3-(6-methylhept-5-en-2-yl)-2-nitrophenol (5) groups. Meanwhile the other is the known compound, that is (R)-2-methyl-5-(6-methylhept-5-en-2-yl)-4-nitrophenol (6). The caspase-7 inhibitory activity of compounds 1-6 was evaluated as well. In comparison to other derivatives, compounds 5 and 6 exhibited higher activity. Consequently, compounds 5 and 6 may be a promising lead compound for further development as a caspase-7 inhibitor.

2.
MethodsX ; 10: 102185, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37152668

RESUMO

This study aims to analyze the potential and characteristics of biodiesel and activated carbon from spent coffee grounds (SCG).•Biodiesel was obtained by extracting oil from SCG using Soxhlet extraction method with n-hexane solvent with an oil yield of 18.14% w/w of dry SCG. Furthermore, the coffee oil was esterified and transesterified to produce biodiesel with 57.32 % yield of coffee oil and higher heating value of 36.69 MJ/kg, density (15°C) of 0.89 g/mL, kinematic viscosity (40°C) of 7.67 mm2/s, acid number of 1.19 mg KOH/g oil.•The residue in form of grounds after oil extraction process was turned into activated carbon using two step activation process. Carbonization process was carried out at 500, 600, 700, and 800°C for 30 minutes and then chemically activated using potassium hydroxide (KOH) at 750°C for 2 hours. As the comparison, activated carbon was also made from SCG without oil extraction process. This study shows that the adsorption capacity of activated carbon made from SCG with oil extraction was better than without oil extraction. The best adsorption of activated carbon was obtained from SCG with oil extraction and carbonized at 700°C with iodine value of 1,224.59 mg/g and methylene blue value of 153.08 mg/g.

3.
Z Naturforsch C J Biosci ; 69(9-10): 375-80, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25711038

RESUMO

Previously we had isolated two prenylated flavanones and two prenylated dihydrochalcones, macatrichocarpins A-D (1-4), from the acetone extract of the leaves of Macaranga trichocarpa. Re-examination of the fractions containing minor components resulted in the isolation of four more flavonoid derivatives, including two new prenylated dihydrochalcones, oxymacatrichocarpin C (5) and isomacatrichocarpin C (6). The structures of these compounds were determined by the analysis of UV, NMR, and mass spectral data. The eight isolated flavonoids were tested on eight pathogenic bacteria and found to be mostly moderate antibacterial agents, with the lowest MIC value of 26.5 µM achieved by the flavanone macatrichocarpin A (1) against Bacillus subtilis.


Assuntos
Antibacterianos/química , Chalconas/química , Euphorbiaceae/química , Flavanonas/química , Avaliação Pré-Clínica de Medicamentos , Flavonas/química , Flavonoides/química , Espectroscopia de Ressonância Magnética , Testes de Sensibilidade Microbiana , Extratos Vegetais/química , Folhas de Planta/química , Raios Ultravioleta
4.
Nat Prod Commun ; 5(8): 1209-11, 2010 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-20839620

RESUMO

Two geranylated and methylated flavonol derivatives, macarhizinoidins A (1) and B (2), along with a known phenolic compound methyl 4-isoprenyloxycinnamate (3), have been isolated from the methanol extract of the leaves M. rhizinoides. The structures of these compounds were identified based on their spectroscopic data. On cytotoxic evaluation against murine leukemia P-388 cells, compounds 1-2 showed IC50 values of 11.4 and 13.9 microM, respectively, while compound 3 was inactive.


Assuntos
Euphorbiaceae/química , Flavonóis/isolamento & purificação , Animais , Flavonóis/química , Flavonóis/farmacologia , Leucemia P388/tratamento farmacológico , Leucemia P388/patologia , Camundongos , Extratos Vegetais/análise
5.
Nat Prod Res ; 23(7): 591-4, 2009.
Artigo em Inglês | MEDLINE | ID: mdl-19401910

RESUMO

A new oligostilbenoid, diptoindonesin C, has been isolated from the tree bark of Shorea pinanga Scheff., along with the two known oligostilbenoids gnetin H and hopeaphenol, and a known coumarin scopoletin. The new oligostilbenoid was moderately active against brine shrimps Artemia salina.


Assuntos
Dipterocarpaceae/química , Casca de Planta/química , Extratos Vegetais/isolamento & purificação , Estilbenos/isolamento & purificação , Estrutura Molecular , Fenóis , Estilbenos/análise , Estilbenos/química
6.
J Asian Nat Prod Res ; 11(11): 929-32, 2009 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-20183255

RESUMO

A new farnesylated flavonol derivative, macagigantin (1), together with two known flavonoids, glyasperin A (2) and apigenin (3), had been isolated from the acetone extract of the leaves of Macaranga gigantea. The structure of the new compound was elucidated as 6-farnesylkaempferol based on its spectroscopic data, including UV, IR, 1D and 2D NMR, and HR-EI-MS spectra. Compounds 1-3 were evaluated for their cytotoxic properties against P-388 cells, their IC(50) values being 11.3, 6.0, and 5.1 microM, respectively.


Assuntos
Antineoplásicos Fitogênicos/isolamento & purificação , Euphorbiaceae/química , Flavonóis/isolamento & purificação , Animais , Antineoplásicos Fitogênicos/química , Antineoplásicos Fitogênicos/farmacologia , Ensaios de Seleção de Medicamentos Antitumorais , Flavonóis/química , Flavonóis/farmacologia , Indonésia , Leucemia P388 , Camundongos , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Folhas de Planta/química , Relação Estrutura-Atividade
7.
Fitoterapia ; 75(2): 134-40, 2004 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-15030917

RESUMO

Two new isoprenylated flavones, artoindonesianins U (1) and V (2), have been isolated from the heartwood of Artocarpus champeden together with three known isoprenylated flavonoids, 5'-hydroxycudraflavone A, cyclocommunin and artonin B. The structures of the new flavones were elucidated on the basis of spectroscopic evidence. Both compounds 1 and 2 showed strong cytotoxic activity against P-388 cell lines.


Assuntos
Antineoplásicos Fitogênicos/farmacologia , Artocarpus , Flavonoides/farmacologia , Fitoterapia , Extratos Vegetais/farmacologia , Antineoplásicos Fitogênicos/administração & dosagem , Antineoplásicos Fitogênicos/química , Antineoplásicos Fitogênicos/uso terapêutico , Linhagem Celular Tumoral/efeitos dos fármacos , Flavonoides/administração & dosagem , Flavonoides/química , Flavonoides/uso terapêutico , Humanos , Extratos Vegetais/administração & dosagem , Extratos Vegetais/química , Extratos Vegetais/uso terapêutico
8.
Phytochemistry ; 61(8): 949-53, 2002 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-12453523

RESUMO

Four isoprenylated flavones, artoindonesianins Q-T, were isolated from the heartwood of Artocarpus champeden Roxb. The structures of these compounds were elucidated on the basis of their spectroscopic data.


Assuntos
Artocarpus/química , Flavonoides/química , Flavonoides/isolamento & purificação , Espectroscopia de Ressonância Magnética , Estrutura Molecular , Componentes Aéreos da Planta/química
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