[The efficiency of modernmethods of laboratory diagnosis in the evaluation of various forms of hemorrhagic fever with renal syndrome caused by the Puumala hantavirus (PUUV).]

We've conducted the analysis of both traditional and new methods of laboratory diagnosis to estimate the severity and damage of target organs during Hemorrhagic Fever with Renal Syndrome (HFRS). It was shown that thrombocytopenia corresponds to the severity of the disease and correlates with the severity of renal failure. The level of C-reactive protein reflects the activity of the inflammatory process and correlates with the characteristic laboratory criteria of the disease. Blood serum levels of alveomucine in patients with HFRS more than 45.0 U/ml indicates lung damage. HFRS on the territory of the Bashkortostan Republic is caused by the serotype of Puumala hantavirus; dependence of the form of the disease on the content of antiviral antibodies is not revealed.

[The diagnostic significance of testing cerebral natriuretic propeptide in patients with hemorrhagic fever and renal syndrome].

The study of content of cerebral natriuretic propeptide (NT-proBNP) in patients with hemorrhagic fever and renal syndrome was carried out considering severity degree, period of disease, presence of clinical roentgenological signs of lungs affection. It is demonstrated that in patients with mild and severe degree of disease the content of NT-proBNP is reliably higher than in the control group and gets its peak values in oliguric period The indices of NT-proBNP are reliably higher in patients with clinical roentgenological signs of lungs affection as compared with patients without such signs. The correlation analysis revealed direct dependence between the content of NT-proBNP and systolic blood pressure in pulmonary artery in in patients with hemorrhagic fever and renal syndrome of mild severity

[Clinical and morphological parallels in lung lesions associated with hemorrhagic fever with renal syndrome].

The authors report the results of clinical examination of the respiratory, organs of 97 patients with hemorrhagic fever and renal syndrome (HFRS) with confirmed Puumala serotype. Retrospective analysis of 16 fatal cases is presented. It is shown that patients with moderately severe and severe forms of the disease exhibit early clinical and X-ray signs of pulmonary lesions and respiratory insufficiency Some of them suffer acute respiratory distress syndrome confirmed by morphological findings at autopsy.

[Cardiopulmonary syndrome in hantavirus infection (an overview)].

The article provides an overview of domestic and foreign literature on modern aspects of hantavirus infection. Hemorrhagic fever with renal syndrome and hantavirus cardiopulmonary syndrome have a high epidemiological significance for Russia's Armed Forces and the armies of many foreign countries. Current knowledge of the various manifestations of the disease contribute to the improvement of diagnosis and timely delivery of medical and preventive measures.

[The diagnostic significance of alveomucin in patients with hemorrhagic fever with renal syndrome].

The article considers the results of analysis of serum alveomucin levels in 97 patients with hemorrhagic fever with renal syndrome depending on the form and period of disease. It is demonstrated that in patients with hemorrhagic fever with renal syndrome and clinical radiologic symptoms of lung affection already in initial period of disease the level of serum alveomucin is reliably higher than in the control group and the group of patients with hemorrhagic fever with renal syndrome and without lung affection. The correlation analysis revealed the reverse dependence between the level of alveomucin and arterial blood saturation with oxygen in patients with hemorrhagic fever with renal syndrome and disease form of medium severity.

[The diagnostic value of serum alveomucin test in diseases with lungs affection].

The study was organized to determine the diagnostic value of concentration of blood serum alveo-mucin as a marker of lesion of lung tissue in patients with community-acquired pneumonia and hemorrhagic fever with renal syndrome. The sampling included 86 patients with community-acquired pneumonia and 97 patients with hemorrhagic fever with renal syndrome. The patients with community-acquired pneumonia were divided in three groups according severity of disease course: slight form, medium-severe form and severe form of disease. The group of patients with medium-severe form of hemorrhagic fever with renal syndrome was divided on two groups depending on clinical roentgenologic pattern: with and without pathology of lungs. The high concentration of alveomucin at the day of hospitalization is typical for patients both with community-acquired pneumonia and with roentgenologically approved lungs affection in case of hemorrhagic fever with renal syndrome in comparison with patients with hemorrhagic fever with renal syndrome without affection of lung tissue (p=0.046). The concentration of alveomucin higher than 47.2 U/ml is established in 86% of patients with community-acquired pneumonia and affection of lung in case of hemorrhagic fever with renal syndrome and in 12% of patients with hemorrhagic fever with renal syndrome without affection of lungs (chi2=0.58 with Yeats equalization, p=0.44).