[Effect of izoturon and its combination with ganglionic blockaders and alpha-adrenoblockaders on systemic hemodynamics in traumatic shock]. / Vliianie izoturona i ego kombinatsii s ganglioblokatorami i al'fa-adrenoblokatorami na sistemnuiu gemodinamiku pri travmaticheskom shoke.

Isoturone (5 mg/kg) administered in a single dose intravenously to unanesthetized cats in a torpid phase of traumatic shock increases arterial blood pressure (BP) and total peripheral vascular resistance (TPVR). The drug restores BP level mainly due to an increase of TPVR against background of neurovegetative blockade induced by pentamine, phentolamine and combinations of phentolamine with hexonium in the presence of a severe trauma. Vascular sensitivity to isoturone in traumatic shock is preserved and considerably increases during the use of the vasopressor in different types of neurovegetative blockade.

[Effect of prednisolone, hyperbaric oxygenation and their combination on the glucose content of the blood and glycogen in the organs of white rats]. / Vliianie prednizolona, giperbaricheskoi oksigenatsii i ikh sochetaniia na soderzhanie gliukozy v krovi i glikogena v organakh belykh krys.

A single injection of prednisolone in doses of 10, 30, 80 and 100 mg/kg provoked different shifts in blood glucose concentration and glycogen content in the heart, liver, and skeletal muscles. Prednisolone increased liver glycogen content almost in all the doses. Administered in doses of 10 and 30 mg/kg the drug reduced blood glucose level and glycogen content in the myocardium and skeletal muscles. Administered in doses of 80 and 100 mg/kg the drug produced almost no effect on the characteristics under consideration or increased them. Oxygen raised glycogen liver content, blood glucose level, reduced the content of the polysaccharide in the skeletal muscles at a pressure of 3039 Pa (3 at. abs). Combined use of prednisolone and oxygen at an elevated pressure led, depending on the drug dose, to the occurrence of the phenomena of either synergism or antagonism.

[Effect of etiron in combination with fentolamin on systemic hemodynamics]. / Vliianie étirona v kombinatsii s fentolaminom na sistemnuiu gemodinamiku.

Etiron is capable to recover arterial pressure reduced by phentolamine, and to correct, to a certain degree, other parameters of the systemic hemodynamics, that change after administering an alpha-adrenoblocker. The recovery of arterial pressure occurs mainly at the expense of the increased general peripheral resistance, whereas the minute circulatory volume remains almost unchanged.

[Prevention of the provoking action of insulin on oxygen poisoning and the preservation of specific properties of the preparation under hyperbaric oxygenation]. / O preduprezhdenii provotsiruiushchego deistviia insulina na kislorodnoe otravlenie i sokhranenii spetsificheskikh svoistv preparata v usloviialkh giperbaricheskoi oksigenatsii.

It has been shown in experiments on rats exposed to oxygen under a pressure of 4558.5 PA (4.5 at. abs) for 1 h that phentolamine (5 mg/kg) and etiron (20 mg/kg) reduced or prevented the provoking action of insulin (3 units/kg) on the convulsant oxygen syndrome and pulmonary involvement. Inderal (1.5 mg/kg) was effective only as regards lung defence, whereas diazepam (5 mg/kg) intensified pulmonary involvement and displayed an insignificant anticonvulsant action. Phentolamine, etiron and diazepam applied in conjunction with insulin promoted the preservation or potentiation of the hypoglycemic and hypokalemic effects characteristic for insulin. In this case inderal provoked hypoglycemia and prevented oxygen-induced hyperkalemia.

[Effect of fentolamin and its combination with etiron on microcirculation]. / Vliianie fentolamina i ego sochetaniia s étironom na mikrotsirkuliatsiiu.

It has been shown in experiments on rats anesthetized with thiopental that intravenous injection of phentolamine in a dose of 10 mg/kg enlarges the microvessels of the mesoappendix, pia mater, liver and kidneys and raises the number of functioning capillaries. Administration of etiron after phentolamine stabilized AP and corrects microcirculation. The drug raises the tone of the microvessels when applied locally in a dose of 0.15 ml (1 : 5000) or intravenously in a dose of 20 mg/kg. Etiron largely produces the constriction of the distal vessels of the arterial area of the microvascular bloodstream. The diameter of the microvessels diminished to a greater degree after intravenous injection of etiron in the presence of a alpha-adrenoreceptor blockade as compared to local application. The sensitivity of the microvessels to etiron administered after phentolamine is inversely proportional to their diameter. Combined use of etiron with alpha-adrenoblockers considerably widens the possibilities of drug control of the vascular tone.