[Predictors of severe course of atopic dermatitis].

Atopic dermatitis (AD) is a common inflammatory skin disease that occurs most frequently in children. The disease is characterized as chronic, but only 20% of children suffer from severe AD, while the other 80% reach a long-term remission by the age of 8. The aim of the research was the analysis of modern sources of domestic and foreign literature, highlighting the features of the course of severe forms of AD. Results. The multifactorial nature of AD pathogenesis, based on the complex interaction of genetic factors, the immune system, the skin microbiome and environmental factors, causes certain difficulties for the physician, both in the diagnosis and therapy selection, and in predicting the course of the disease. Each patient has his own individual combination of clinical symptoms, medical history and aggravating factors that should be considered as predictors of the severity of the disease. Conclusion. Particular attention should be paid to patients with an early onset of AD, increased transepidermal water loss, with extensive skin lesions at the onset of the disease and under dynamic observation, with concomitant food allergies and/or bronchial asthma.

[Alternative food for рatients with allergу to the egg].

Patients suffering from food allergy/food intolerance of eggs need alternative products that do not cause allergic reactions. The purpose of the research: to evaluate guinea fowl egg and meat tolerance among children with chicken egg allergy. There has been conducted single-centre prospective research into intolerance of the products. Appearance or increase in skin or gastrointestinal allergic symptoms was registered; the concentration of specific IgE antibodies against chicken egg and meat in blood serum was assessed. As alternative products, the children were offered guinea fowl egg and meat; these products were given to them during 14 days. In the research 40 children (23 girls and 17 boys) from the age of 8 months to 1.5 years old took part; all children were diagnosed with atopic dermatitis, one of its triggers was chicken egg. Exacerbation of skin allergy was connected with eating chicken egg, which was confirmed by the results of the allergy examination. 28 (70.0%) children were diagnosed as having the mild form of atomic dermatitis, while 12 (30.0%) patients had the moderate form of atomic dermatitis. At the beginning of the research the patients were divided into 2 equal groups (each group of 20 patients). The first group consisted of the children aged 8 moths - 1.5 years old who received 1/2 guinea fowl egg every other day. The second group consisted of the patients aged 1.5-3 years old who received 60-90 grams fowl egg meat per day. The research has revealed that the children showed tolerance of guinea fowl egg and meat, the majority of the patients did not experience any skin or gastrointestinal allergic reactions. It has also been shown that at the end of the research the majority of the children (73.3%) had a decrease in concentration of specific IgE antibodies against chicken egg and meat in blood serum. According to the allergy examination, 8 (26.7%) children experienced an increase in skin sensitization to chicken egg and meat, which coincided with exacerbation of skin allergy. Thus, the examined products can be used as alternative products for those children who suffer from food allergy/food intolerance of chicken egg and meat.

[Phenotypes of food allergy in children].

Questions of food allergy heterogeneity, approaches to allocation of various phenotypes on the basis of clinical signs and immunological markers taking into account an etiology and immune mechanisms of the disease are considered in the article. Allocation of phenotypes contributes the best understanding of essence and it expedient for development of individual approach to diet and therapy.