Employing Supervised Algorithms for the Prediction of Nanomaterial's Antioxidant Efficiency.

Reactive oxygen species (ROS) are compounds that readily transform into free radicals. Excessive exposure to ROS depletes antioxidant enzymes that protect cells, leading to oxidative stress and cellular damage. Nanomaterials (NMs) exhibit free radical scavenging efficiency representing a potential solution for oxidative stress-induced disorders. This study aims to demonstrate the application of machine learning (ML) algorithms for predicting the antioxidant efficiency of NMs. We manually compiled a comprehensive dataset based on a literature review of 62 in vitro studies. We extracted NMs' physico-chemical (P-chem) properties, the NMs' synthesis technique and various experimental conditions as input features to predict the antioxidant efficiency measured by a 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. Following data pre-processing, various regression models were trained and validated. The random forest model showed the highest predictive performance reaching an R2 = 0.83. The attribute importance analysis revealed that the NM's type, core-size and dosage are the most important attributes influencing the prediction. Our findings corroborate with those of the prior research landscape regarding the importance of P-chem characteristics. This study expands the application of ML in the nano-domain beyond safety-related outcomes by capturing the functional performance. Accordingly, this study has two objectives: (1) to develop a model to forecast the antioxidant efficiency of NMs to complement conventional in vitro assays and (2) to underline the lack of a comprehensive database and the scarcity of relevant data and/or data management practices in the nanotechnology field, especially with regards to functionality assessments.

(Re)Conceptualizing decision-making tools in a risk governance framework for emerging technologies-the case of nanomaterials.

The utility of decision-making tools for the risk governance of nanotechnology is at the core of this paper. Those working in nanotechnology risk management have been prolific in creating such tools, many derived from European FP7 and H2020-funded projects. What is less clear is how such tools might assist the overarching ambition of creating a fair system of risk governance. In this paper, we reflect upon the role that tools might and should play in any system of risk governance. With many tools designed for the risk governance of this emerging technology falling into disuse, this paper provides an overview of extant tools and addresses their potential shortcomings. We also posit the need for a data readiness tool. With the EUs NMP13 family of research consortia about to report to the Commission on ways forward in terms of risk governance of this domain, this is a timely intervention on an important element of any risk governance system.

The risk perception of nanotechnology: evidence from twitter.

Nanotechnology governance, particularly in relation to human and environmental concerns, remains a contested domain. In recent years, the creation of both a risk governance framework and council has been actively pursued. Part of the function of a governance framework is the communication to external stakeholders. Existing descriptions on the public perceptions of nanotechnology are generally positive with the attendant economic and societal benefits being forefront in that thinking. Debates on nanomaterials' risk tend to be dominated by expert groupings while the general public is largely unaware of the potential hazards. Communicating via social media has become an integral part of everyday life facilitating public connectedness around specific topics that was not feasible in the pre-digital age. When civilian passive stakeholders become active their frustration can quickly coalesce into a campaign of resistance, and once an issue starts to develop into a campaign it is difficult to ease the momentum. Simmering discussions with moderate local attention can gain international exposure resulting in pressure and it can, in some cases, quickly precipitate legislative action and/or economic consequences. This paper highlights the potential of such a runaway, twitterstorm. We conducted a sentiment analysis of tweets since 2006 focusing on silver, titanium and carbon-based nanomaterials. We further examined the sentiment expressed following the decision by the European Food Safety Authority (EFSA) to phase out the food additive titanium dioxide (E 171). Our analysis shows an engaged, attentive public, alert to announcements from industry and regulatory bodies. We demonstrate that risk governance frameworks, particularly the communication aspect of those structures must include a social media blueprint to counter misinformation and alleviate the potential impact of a social media induced regulatory and economic reaction.

Cyber risk and cybersecurity: a systematic review of data availability.

Cybercrime is estimated to have cost the global economy just under USD 1 trillion in 2020, indicating an increase of more than 50% since 2018. With the average cyber insurance claim rising from USD 145,000 in 2019 to USD 359,000 in 2020, there is a growing necessity for better cyber information sources, standardised databases, mandatory reporting and public awareness. This research analyses the extant academic and industry literature on cybersecurity and cyber risk management with a particular focus on data availability. From a preliminary search resulting in 5219 cyber peer-reviewed studies, the application of the systematic methodology resulted in 79 unique datasets. We posit that the lack of available data on cyber risk poses a serious problem for stakeholders seeking to tackle this issue. In particular, we identify a lacuna in open databases that undermine collective endeavours to better manage this set of risks. The resulting data evaluation and categorisation will support cybersecurity researchers and the insurance industry in their efforts to comprehend, metricise and manage cyber risks. Supplementary Information: The online version contains supplementary material available at 10.1057/s41288-022-00266-6.

Creating ethics guidelines for artificial intelligence and big data analytics customers: The case of the consumer European insurance market.

The European Union (EU) has a strong reputation and track record for the development of guidelines for the ethical use of artificial intelligence (AI) generally. In this paper, we discuss the development of an AI and ethical framework by the European Insurance and Occupational Pensions Authority (EIOPA), for the European insurance market. EIOPA's earlier report on big data analytics (EIOPA, 2019) provided a foundation to analyze the complex range of issues associated with AI being deployed in insurance, such as behavioral insurance, parametric products, novel pricing and risk assessment algorithms, e-service, and claims management. The paper presents an overview of AI in insurance applications throughout the insurance value chain. A general discussion of ethics, AI, and insurance is provided, and a new hierarchical model is presented that describes insurance as a complex system that can be analyzed by taking a layered, multi-level approach that maps ethical issues directly to specific level(s).

A Machine Learning Tool to Predict the Antibacterial Capacity of Nanoparticles.

The emergence and rapid spread of multidrug-resistant bacteria strains are a public health concern. This emergence is caused by the overuse and misuse of antibiotics leading to the evolution of antibiotic-resistant strains. Nanoparticles (NPs) are objects with all three external dimensions in the nanoscale that varies from 1 to 100 nm. Research on NPs with enhanced antimicrobial activity as alternatives to antibiotics has grown due to the increased incidence of nosocomial and community acquired infections caused by pathogens. Machine learning (ML) tools have been used in the field of nanoinformatics with promising results. As a consequence of evident achievements on a wide range of predictive tasks, ML techniques are attracting significant interest across a variety of stakeholders. In this article, we present an ML tool that successfully predicts the antibacterial capacity of NPs while the model's validation demonstrates encouraging results (R2 = 0.78). The data were compiled after a literature review of 60 articles and consist of key physico-chemical (p-chem) properties and experimental conditions (exposure variables and bacterial clustering) from in vitro studies. Following data homogenization and pre-processing, we trained various regression algorithms and we validated them using diverse performance metrics. Finally, an important attribute evaluation, which ranks the attributes that are most important in predicting the outcome, was performed. The attribute importance revealed that NP core size, the exposure dose, and the species of bacterium are key variables in predicting the antibacterial effect of NPs. This tool assists various stakeholders and scientists in predicting the antibacterial effects of NPs based on their p-chem properties and diverse exposure settings. This concept also aids the safe-by-design paradigm by incorporating functionality tools.

A new version of the Behaviour of Young Novice Drivers Scale (BYNDS). Insights from a randomised sample of 700 German young novice drivers.

In Germany, every year 66,000 road crashes lead to death or injury of young novice drivers. This makes them twice as likely to be involved in, or cause, vehicle crashes compared to their older and more experienced counterparts. This study aims to address this societal issue by developing a better understanding of the German young driver problem. For this purpose, we created an updated, 55-item strong version of the Behaviour of Young Novice Drivers Scale (BYNDS), originally developed by Scott-Parker et al. in 2010. To make the new version of the BYNDS understandable for German young novice drivers, this research used a new method of translation in combination with extensive pre-testing. As a result, we identified possible threats for response errors such as retrospective formulated questions or double negations. Due the adjustment of the possible sources of error the presented version of the BYNDS is semantically and conceptually different from the original. However, due to the application of the updated version of the BYNDS in a robust sample of 700 participants, this paper presents the first reliable and validated tool to measure novices risky driving behaviour in Germany. Moreover, it offers an updated and extended version of the BYNDS that allows practitioners but also researchers to broaden their understanding of young driver risk.

Exploring the role of delta-V in influencing occupant injury severities - A mediation analysis approach to motor vehicle collisions.

This study investigates the impact that delta-V, the relative change in vehicle velocity pre- and post-crash, has on the severity of motor vehicle collisions (MVCs). We study injury severity using two metrics for each occupant - the number of injuries suffered, and the probability of suffering a serious or worse (MAIS 3+) injury. We use a cross-sectional set of generally-representative MVC data between 2010 and 2015 as a basis for our research. Collision factors that influence the crash environment are combined with the injuries that were suffered in MVCs. The influence of delta-V is captured using a mediation analysis, whereby delta-V acts as the focal point between crash factors and injury outcome. The mediation approach adds to existing research by presenting a detailed view of the relationship between injury severity, delta-V and other collision factors. We find evidence of competitive mediation, wherein a collision factor's positive association with injury severity is offset by a negative association with delta-V. Neglecting to include delta-V in our study would have let the factor's association with injury severity go undiscovered. In addition, certain collision factors are found to be related to injury severity solely because of delta-V, while others are found to have a significant impact regardless of delta-V. Our results support the multitude of policy recommendations that promote seatbelt use and warn against alcohol-impaired driving, and support the proliferation of safety-enabled vehicles whose technology can mitigate the bodily damage associated with detrimental crash types.

Nanotoxicology data for in silico tools: a literature review.

The exercise of non-testing approaches in nanoparticles (NPs) hazard assessment is necessary for the risk assessment, considering cost and time efficiency, to identify, assess, and classify potential risks. One strategy for investigating the toxicological properties of a variety of NPs is by means of computational tools that decode how nano-specific features relate to toxicity and enable its prediction. This literature review records systematically the data used in published studies that predict nano (eco)-toxicological endpoints using machine learning models. Instead of seeking mechanistic interpretations this review maps the pathways followed, involving biological features in relation to NPs exposure, their physico-chemical characteristics and the most commonly predicted outcomes. The results, derived from published research of the last decade, are summarized visually, providing prior-based data mining paradigms to be readily used by the nanotoxicology community in computational studies.

Practices and Trends of Machine Learning Application in Nanotoxicology.

Machine Learning (ML) techniques have been applied in the field of nanotoxicology with very encouraging results. Adverse effects of nanoforms are affected by multiple features described by theoretical descriptors, nano-specific measured properties, and experimental conditions. ML has been proven very helpful in this field in order to gain an insight into features effecting toxicity, predicting possible adverse effects as part of proactive risk analysis, and informing safe design. At this juncture, it is important to document and categorize the work that has been carried out. This study investigates and bookmarks ML methodologies used to predict nano (eco)-toxicological outcomes in nanotoxicology during the last decade. It provides a review of the sequenced steps involved in implementing an ML model, from data pre-processing, to model implementation, model validation, and applicability domain. The review gathers and presents the step-wise information on techniques and procedures of existing models that can be used readily to assemble new nanotoxicological in silico studies and accelerates the regulation of in silico tools in nanotoxicology. ML applications in nanotoxicology comprise an active and diverse collection of ongoing efforts, although it is still in their early steps toward a scientific accord, subsequent guidelines, and regulation adoption. This study is an important bookend to a decade of ML applications to nanotoxicology and serves as a useful guide to further in silico applications.

Machine learning prediction of nanoparticle in vitro toxicity: A comparative study of classifiers and ensemble-classifiers using the Copeland Index.

Nano-Particles (NPs) are well established as important components across a broad range of products from cosmetics to electronics. Their utilization is increasing with their significant economic and societal potential yet to be fully realized. Inroads have been made in our understanding of the risks posed to human health and the environment by NPs but this area will require continuous research and monitoring. In recent years Machine Learning (ML) techniques have exploited large datasets and computation power to create breakthroughs in diverse fields from facial recognition to genomics. More recently, ML techniques have been applied to nanotoxicology with very encouraging results. In this study, categories of ML classifiers (rules, trees, lazy, functions and bayes) were compared using datasets from the Safe and Sustainable Nanotechnology (S2NANO) database to investigate their performance in predicting NPs in vitro toxicity. Physicochemical properties, toxicological and quantum-mechanical attributes and in vitro experimental conditions were used as input variables to predict the toxicity of NPs based on cell viability. Voting, an ensemble meta-classifier, was used to combine base models to optimize the classification prediction of toxicity. To facilitate inter-comparison, a Copeland Index was applied that ranks the classifiers according to their performance and suggested the optimal classifier. Neural Network (NN) and Random forest (RF) showed the best performance in the majority of the datasets used in this study. However, the combination of classifiers demonstrated an improved prediction resulting meta-classifier to have higher indices. This proposed Copeland Index can now be used by researchers to identify and clearly prioritize classifiers in order to achieve more accurate classification predictions for NP toxicity for a given dataset.

Application of Bayesian networks in determining nanoparticle-induced cellular outcomes using transcriptomics.

Inroads have been made in our understanding of the risks posed to human health and the environment by nanoparticles (NPs) but this area requires continuous research and monitoring. Machine learning techniques have been applied to nanotoxicology with very encouraging results. This study deals with bridging physicochemical properties of NPs, experimental exposure conditions and in vitro characteristics with biological effects of NPs on a molecular cellular level from transcriptomics studies. The bridging is done by developing and implementing Bayesian Networks (BNs) with or without data preprocessing. The BN structures are derived either automatically or methodologically and compared. Early stage nanotoxicity measurements represent a challenge, not least when attempting to predict adverse outcomes and modeling is critical to understanding the biological effects of exposure to NPs. The preprocessed data-driven BN showed improved performance over automatically structured BN and the BN with unprocessed datasets. The prestructured BN captures inter relationships between NP properties, exposure condition and in vitro characteristics and links those with cellular effects based on statistic correlation findings. Information gain analysis showed that exposure dose, NP and cell line variables were the most influential attributes in predicting the biological effects. The BN methodology proposed in this study successfully predicts a number of toxicologically relevant cellular disrupted biological processes such as cell cycle and proliferation pathways, cell adhesion and extracellular matrix responses, DNA damage and repair mechanisms etc., with a success rate >80%. The model validation from independent data shows a robust and promising methodology for incorporating transcriptomics outcomes in a hazard and, by extension, risk assessment modeling framework by predicting affected cellular functions from experimental conditions.

Semiautonomous Vehicle Risk Analysis: A Telematics-Based Anomaly Detection Approach.

The transition to semiautonomous driving is set to considerably reduce road accident rates as human error is progressively removed from the driving task. Concurrently, autonomous capabilities will transform the transportation risk landscape and significantly disrupt the insurance industry. Semiautonomous vehicle (SAV) risks will begin to alternate between human error and technological susceptibilities. The evolving risk landscape will force a departure from traditional risk assessment approaches that rely on historical data to quantify insurable risks. This article investigates the risk structure of SAVs and employs a telematics-based anomaly detection model to assess split risk profiles. An unsupervised multivariate Gaussian (MVG) based anomaly detection method is used to identify abnormal driving patterns based on accelerometer and GPS sensors of manually driven vehicles. Parameters are inferred for vehicles equipped with semiautonomous capabilities and the resulting split risk profile is determined. The MVG approach allows for the quantification of vehicle risks by the relative frequency and severity of observed anomalies and a location-based risk analysis is performed for a more comprehensive assessment. This approach contributes to the challenge of quantifying SAV risks and the methods employed here can be applied to evolving data sources pertinent to SAVs. Utilizing the vast amounts of sensor-generated data will enable insurers to proactively reassess the collective performances of both the artificial driving agent and human driver.

Hazard Screening Methods for Nanomaterials: A Comparative Study.

Hazard identification is the key step in risk assessment and management of manufactured nanomaterials (NM). However, the rapid commercialisation of nano-enabled products continues to out-pace the development of a prudent risk management mechanism that is widely accepted by the scientific community and enforced by regulators. However, a growing body of academic literature is developing promising quantitative methods. Two approaches have gained significant currency. Bayesian networks (BN) are a probabilistic, machine learning approach while the weight of evidence (WoE) statistical framework is based on expert elicitation. This comparative study investigates the efficacy of quantitative WoE and Bayesian methodologies in ranking the potential hazard of metal and metal-oxide NMs-TiO2, Ag, and ZnO. This research finds that hazard ranking is consistent for both risk assessment approaches. The BN and WoE models both utilize physico-chemical, toxicological, and study type data to infer the hazard potential. The BN exhibits more stability when the models are perturbed with new data. The BN has the significant advantage of self-learning with new data; however, this assumes all input data is equally valid. This research finds that a combination of WoE that would rank input data along with the BN is the optimal hazard assessment framework.

Applying crash data to injury claims - an investigation of determinant factors in severe motor vehicle accidents.

An extensive number of research studies have attempted to capture the factors that influence the severity of vehicle impacts. The high number of risks facing all traffic participants has led to a gradual increase in sophisticated data collection schemes linking crash characteristics to subsequent severity measures. This study serves as a departure from previous research by relating injuries suffered in road traffic accidents to expected trauma compensation payouts and deriving a quantitative cost function. Data from the National Highway Traffic Safety Administration's (NHTSA) Crash Injury Research (CIREN) database for the years 2005-2014 is combined with the Book of Quantum, an Irish governmental document that offers guidelines on the appropriate compensation to be awarded for injuries sustained in accidents. A multiple linear regression is carried out to identify the crash factors that significantly influence expected compensation costs and compared to ordered and multinomial logit models. The model offers encouraging results given the inherent variation expected in vehicular incidents and the subjectivity influencing compensation payout judgments, attaining an adjusted-R2 fit of 20.6% when uninfluential factors are removed. It is found that relative speed at time of impact and dark conditions increase the expected costs, while rear-end incidents, incident sustained in van-based trucks and incidents sustained while turning result in lower expected compensations. The number of airbags available in the vehicle is also a significant factor. The scalar-outcome approach used in this research offers an alternative methodology to the discrete-outcome models that dominate traffic safety analyses. The results also raise queries on the future development of claims reserving (capital allocations earmarked for future expected claims payments) as advanced driver assistant systems (ADASs) seek to eradicate the most frequent types of crash factors upon which insurance mathematics base their assumptions.

The Essential Elements of a Risk Governance Framework for Current and Future Nanotechnologies.

Societies worldwide are investing considerable resources into the safe development and use of nanomaterials. Although each of these protective efforts is crucial for governing the risks of nanomaterials, they are insufficient in isolation. What is missing is a more integrative governance approach that goes beyond legislation. Development of this approach must be evidence based and involve key stakeholders to ensure acceptance by end users. The challenge is to develop a framework that coordinates the variety of actors involved in nanotechnology and civil society to facilitate consideration of the complex issues that occur in this rapidly evolving research and development area. Here, we propose three sets of essential elements required to generate an effective risk governance framework for nanomaterials. (1) Advanced tools to facilitate risk-based decision making, including an assessment of the needs of users regarding risk assessment, mitigation, and transfer. (2) An integrated model of predicted human behavior and decision making concerning nanomaterial risks. (3) Legal and other (nano-specific and general) regulatory requirements to ensure compliance and to stimulate proactive approaches to safety. The implementation of such an approach should facilitate and motivate good practice for the various stakeholders to allow the safe and sustainable future development of nanotechnology.

Application of Bayesian networks for hazard ranking of nanomaterials to support human health risk assessment.

In this study, a Bayesian Network (BN) was developed for the prediction of the hazard potential and biological effects with the focus on metal- and metal-oxide nanomaterials to support human health risk assessment. The developed BN captures the (inter) relationships between the exposure route, the nanomaterials physicochemical properties and the ultimate biological effects in a holistic manner and was based on international expert consultation and the scientific literature (e.g., in vitro/in vivo data). The BN was validated with independent data extracted from published studies and the accuracy of the prediction of the nanomaterials hazard potential was 72% and for the biological effect 71%, respectively. The application of the BN is shown with scenario studies for TiO2, SiO2, Ag, CeO2, ZnO nanomaterials. It is demonstrated that the BN may be used by different stakeholders at several stages in the risk assessment to predict certain properties of a nanomaterials of which little information is available or to prioritize nanomaterials for further screening.

A Tractable Method for Measuring Nanomaterial Risk Using Bayesian Networks.

While control banding has been identified as a suitable framework for the evaluation and the determination of potential human health risks associated with exposure to nanomaterials (NMs), the approach currently lacks any implementation that enjoys widespread support. Large inconsistencies in characterisation data, toxicological measurements and exposure scenarios make it difficult to map and compare the risk associated with NMs based on physicochemical data, concentration and exposure route. Here we demonstrate the use of Bayesian networks as a reliable tool for NM risk estimation. This tool is tractable, accessible and scalable. Most importantly, it captures a broad span of data types, from complete, high quality data sets through to data sets with missing data and/or values with a relatively high spread of probability distribution. The tool is able to learn iteratively in order to further refine forecasts as the quality of data available improves. We demonstrate how this risk measurement approach works on NMs with varying degrees of risk potential, namely, carbon nanotubes, silver and titanium dioxide. The results afford even non-experts an accurate picture of the occupational risk probabilities associated with these NMs and, in doing so, demonstrated how NM risk can be evaluated into a tractable, quantitative risk comparator.

Empowering citizens in international governance of nanotechnologies.

The international dialogue on responsible governance of nanotechnologies engages a wide range of actors with conflicting as well as common interests. It is also characterised by a lack of evidence-based data on uncertain risks of in particular engineered nanomaterials. The present paper aims at deepening understanding of the collective decision making context at international level using the grounded theory approach as proposed by Glaser and Strauss in "The Discovery of Grounded Theory" (1967). This starts by discussing relevant concepts from different fields including sociological and political studies of international relations as well as political philosophy and ethics. This analysis of current trends in international law making is taken as starting point for exploring the role that a software decision support tool could play in multi-stakeholder global governance of nanotechnologies. These theoretical ideas are then compared with the current design of the SUN Decision Support System (SUNDS) under development in the European project on Sustainable Nanotechnologies (SUN, www.sun-fp7.eu). Through constant comparison, the ideas are also compared with requirements of different stakeholders as expressed during a user workshop. This allows for highlighting discussion points for further consideration.