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1.
FEBS Lett ; 289(2): 183-6, 1991 Sep 09.
Artigo em Inglês | MEDLINE | ID: mdl-1655523

RESUMO

Human beta 2-glycoprotein (beta 2gpI) cDNA was isolated from a liver cDNA library and sequenced. The cDNA encoded a 19-residue hydrophobic signal peptide followed by the mature beta 2gpI of 326 amino acid residues. In liver and in the hepatoma cell line HepG2 there are two mRNA species of about 1.4 and 4.3 kb, respectively, hybridizing specifically with the beta 2gpI cDNA. Upon isoelectric focusing, recombinant beta 2gpI obtained from expression of beta 2gpI cDNA in baby hamster kidney cells showed the same pattern of bands as beta 2gpI isolated from plasma, and at least 5 polypeptides were visible.


Assuntos
Apolipoproteínas/genética , Glicoproteínas/genética , Sequência de Aminoácidos , Animais , Sequência de Bases , Northern Blotting , Carcinoma Hepatocelular , Clonagem Molecular , Feminino , Vetores Genéticos , Glicoproteínas/isolamento & purificação , Humanos , Fígado/fisiologia , Neoplasias Hepáticas , Dados de Sequência Molecular , Oligodesoxirribonucleotídeos , Placenta/fisiologia , Gravidez , Proteínas Recombinantes/isolamento & purificação , Transfecção , Células Tumorais Cultivadas , beta 2-Glicoproteína I
2.
Ir Med J ; 83(2): 50-3, 1990 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-2391209

RESUMO

A longitudinal study with follow up to the end of 1989 was carried out on 23 patients with AIDS who had attended St. James's Hospital, Dublin, by the end of 1987. Until then only 33 cases of AIDS had been reported in Ireland. The patients, all of whom had antibodies to human immunodeficiency virus (HIV), were predominantly male, young (mean age 31.3 years) and belonged about equally to three major risk groups: homosexuals, intravenous drug abusers (IVDA) and haemophiliacs. AIDS was diagnosed because of oesophageal candidiasis (8 cases), Kaposi's sarcoma (4), mycobacterial infection (4), pneumocystis carinii pneumonia (3), toxoplasmosis (2) or encephalopathy (2). Malignant lymphoma and a variety of infections occurred in the course of illness, and neurological involvement developed in 11 patients (48%). Mortality following diagnosis of AIDS was 39% at one year and 64% after two years. Autopsy in 10 of the 16 deaths contributed much to defining the extent and nature of the disease. The demographic pattern, risk group status, survival and range of complications were broadly similar to the pattern of AIDS as seen elsewhere in developed countries. However, compared to the profile of disease reported from the United States, oesophageal candidiasis (52%) and Mycobacterium tuberculosis (22%) were more prominent, pneumocystis carinii pneumonia (39%), Kaposi's sarcoma (22%) and Mycobacterium avium intracellulare (13%) were less frequent and cryptococcal infection was not identified. These regional variations in the frequency of the various complications and particularly the prominence of tuberculosis, probably reflect the interaction of the immunocompromised patient with the local environment and may have important diagnostic and therapeutic implications.


Assuntos
Síndrome da Imunodeficiência Adquirida/epidemiologia , Infecções Oportunistas/epidemiologia , Síndrome da Imunodeficiência Adquirida/complicações , Síndrome da Imunodeficiência Adquirida/patologia , Adolescente , Adulto , Feminino , Humanos , Irlanda/epidemiologia , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Infecções Oportunistas/complicações , Infecções Oportunistas/patologia , Fatores de Risco
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