The integrity of psychophysical visual function in non-immunocompromised PLHIV (NIPLHIV) without retinitis on antiretroviral therapy (ART).

Purpose: The present study investigated the integrity of contrast sensitivity (CS), colour vision, and pattern evoked vision potentials (VEP) in non-immunocompromised people living with HIV (NIPLHIV) without retinitis. Methods: All participants were visually asymptomatic and no history of ocular disorders, with CD4 counts above 350 cells/mm3, low viral loads and on ART. Thirty NIPLHIV and 30 age-matched HIV negative control groups underwent F100 hue colour assessment, Pelli-Robson contrast sensitivity assessment and pattern-reversal VEP. Results: The median F100 total error scores for NIPLHIV and controls was 33 (IQR: 28;41) and 28 (IQR: 26;48.50) respectively, this was statistically different (p= 0.020). The median P100 amplitude for NIPLHIV was 5.75 µV (IQR: 4.4;8.85) and 4.05 µV (IQR: 3.2;5.8) for controls, this was statistically different (p=0.045). The mean LogCS score 1.83±0.14 and the median P100 peak latency was 105.45 msec (IQR: 102.98;108.98) for NIPLHIV. Higher CD4+ counts were significantly associated with having higher F100 total error scores (OR=0.995; p=0.018), lower P100 amplitudes (OR=1.007; p=0.010) and higher P100 latencies (OR=0.994; p=0.011). Conclusion: Contrast sensitivity function, colour vision, and VEP were uncompromised in NIPLHIV. Associations between CD4 counts with F100 total error scores and P100 latency may aid in the surveillance of vision of NIPLHIV.

Evidence of the Amplitude of Accommodation of School-Going Children in the 21st Century.

Purpose: The study sought to compare the normative amplitude of accommodation (AoA) in school-going children from studies in the 21st century, based on pooled estimates from meta-analyses, to assess their agreement to Hofstetter's average formula. Methods: A PRISMA checklist was used to conduct the review. PubMed, EBSCOHOST and Medline electronic databases were employed, and hand searching resulting in 259 studies up to July 2021. After title and abstract screening, 12 studies underwent full-text screening, resulting in five studies for data extraction. The pooled effect size was determined using meta-analyses for sub-groups by age. A one-sample t-test was used to compare the pool-effect size estimates (monocular) to the expected AoA from Hofstetter's average formula. Results: The comparison of pool estimates of AoA with the expected Hofstetter's average formula for the age sub-groups showed significant mean differences for: six-year olds: mean difference of -3.4 D (95% CI: -5.85; -1.04; p = 0.025); nine-year olds: mean difference of -4.1D (95% CI: -7.95; -0.20; p = 0.043); ten-year olds: mean difference of -4.6D (95% CI: -8.57; -0.54; p = 0.035) and 11-year olds: mean difference of -5.2 D (95% CI: -8.06; -2.40; p = 0.005). According to the quality assessment tool used, overall, the body of evidence was of good quality. Conclusion: Hofstetter's prediction of normative amplitude of accommodation today may over-estimate for children aged six, nine, 10 and 11. The observed under-accommodation estimates from these comparisons may warrant consideration in assessing for a larger lag of accommodation in these age groups with myopia or pre-myopia, as part of the surveillance for progression.

A case study of digital eye strain in a university student population during the 2020 COVID-19 lockdown in South Africa: evidence of an emerging public health issue.

Background: The COVID-19 pandemic resulted in a nationwide lockdown in South Africa, initiating a shift in society's interaction to the online space. Students therefore became reliant on electronic devices for learning. Objective: The study aimed to investigate the prevalence of digital eye strain (DES) in a university student population during the nationwide COVID-19 lockdown in South Africa. Methods: Randomly sampled 290 university students were surveyed online about their screen time and DES during lockdown. The survey included a validated screen time questionnaire to measure screen time in hours per day and a validated computer vision syndrome questionnaire (CVS-Q) to measure the frequency and intensity of symptoms during edevice use (s). Descriptive statistics were used to analyze CVS-Q scores and screen time. Results: The mean (SD) age of the sample was 21.04 _ 2.32 years. Of these, 82.41% used smartphone devices and 55.52% of the participants did not use any optical correction. The prevalence of DES during COVID-19 lockdown in 2020 was 64.24%. Screen time on an average weekday and over the weekend, as a primary activity, had a median of 13 hours per day during lockdown. Conclusion: The high prevalence of digital eye strain may be a harbinger of a decrease in student performance. Creating awareness of proper visual hygiene amongst students is paramount in decreasing the high prevalence of DES.

A protocol for a scoping review to map the assessment approaches in optometry education programmes globally.

BACKGROUND: The training of optometrists aims to prepare practitioners with critical thinking skills who utilise their education and experience to solve clinical problems in real-life practice. Professional competencies should inform assessment, and as such, assessment methods for learning should encompass a wide range of approaches. The objective of this scoping review is therefore to map assessment approaches utilised within optometry education programmes globally. METHODS: This study is a scoping review based on the PRISMA methodology. The review will be guided by the following research question, "What are the assessment approaches that inform optometry training globally?". This was validated by the Population-Concept-Context framework according to the methodology for Joanna Briggs Institution Scoping Reviews. Relevant peer-reviewed studies and grey literature conducted during the last 10 years will be identified from electronic databases including CINAHL, PubMed, PROquest and ERIC. The search strings using keywords such as "Optometry students and staff", "Assessments" and "Optometry education" will be conducted using Boolean logic. An independent reviewer will conduct all title screening, two independent reviewers will conduct abstract and full article screening, followed by data extraction. Thereafter, a thematic analysis will be conducted. The Mixed Method Appraisal Tool version 2018 will be used for quality appraisal of mapped studies. DISCUSSION: The review will document evidence of assessment approaches utilised in optometry training globally. Considering the exit level competencies required in the basic job function of an optometrist, a coherence in assessment approaches and relevant rationale for these would be expected, if the accredited (regulated) training programmes follow a competency-based model.

The Integrity of Retinal Morphology in Non-immunocompromised People Living with HIV on Antiretroviral Therapy.

SIGNIFICANCE: Non-immunocompromised people living with HIV (NIPLHIV) share a similar immunocompetence to non-HIV (HIV) people with an elevated cluster of differentiation 4 (CD4) count in the era of antiretroviral therapy (ART). This has reduced the incidence of HIV retinopathy, thus raising the question of the integrity of the retinal morphology in NIPLHIV with longer life expectancy. PURPOSE: The study assessed the retinal thickness and volume of NIPLHIV without retinitis on ART and attempted to find associations with linear parameters of cerebral atrophy. METHODS: The study was conducted at a public hospital in South Africa. All people living with HIV were on ART with CD4 counts above 350 cells/mm3 and viral loads less than 10,000 copies/mL. The Heidelberg Spectralis ocular coherence tomographer assessed the retinal thickness and volume for comparison between 30 NIPLHIV and 30 HIV-negative participants. A subset of the HIV group obtained a computed tomography scan to determine the bicaudate ratio and the sylvian fissure ratio to assess cerebral atrophy. Independent t tests were performed to identify differences in retinal thickness and volume. Multivariate linear regressions measured associations between retinal thickness and volume with cerebral atrophy. RESULTS: The NIPLHIV group had a thicker mean global temporal subfields at Early Treatment Diabetic Retinopathy Study (ETDRS) 3 mm (P = .047) and ETDRS 6 mm (P = .03). The mean global temporal subfield volume at ETDRS 3 mm was also increased in the NIPLHIV group (P = .02). Nasal macula retinal nerve fiber layer thickness and the inferior inner nuclear layer macula volume were directly related to the bicaudate ratio, whereas the volumes at the outer retinal layer subfields of the macula were inversely related to sylvian fissure ratio in NIPLHIV. CONCLUSIONS: Macula thickness and volumetric differences do exist in NIPLHIV. Practitioners should keep NIPLHIV under retinal morphometric surveillance because they live longer. Associations of cerebral atrophy with retinal morphology may be used to monitor cerebral atrophy in NIPLIV on ART.

A correlation analysis of cone characteristics and central keratometric readings for the different stages of keratoconus.

BACKGROUND: Knowledge of the cone characteristics for the different stages of keratoconus may potentially assist practitioners in diagnosing and managing keratoconic patients. AIM: This study aims to determine if any correlation exists between the central keratometric readings and the cone characteristics for the different stages of keratoconus. SETTING: A university eye clinic. MATERIALS AND METHODS: In this retrospective study, a saturated sample of 190 eyes from 106 cases of previously diagnosed keratoconic patient files was analyzed. The stage of keratoconus and cone characteristics, namely, cone location, cone decentration, topographical patterns, and morphology were analyzed using an Oculus 3M corneal topographer. RESULTS: Analysis revealed a correlation between cone decentration and stage of keratoconus (P = 0.007). The association was found to exist when central K-readings were between 45D and 52D and with an apical cone decentration of 3-4 mm. No correlations were obtained for the stage of keratoconus and the cone location; topography and morphology. CONCLUSION: It can be concluded that cone apices are not central in all stages. Practitioners should consider the peripheral cornea when diagnosing and managing keratoconic patients. No correlation between stage, morphology or topography was respectively revealed.