A novel combination of double primary malignancies: penile carcinoma and glioblastoma. A series of two cases.

AIM: Penile squamous cell carcinoma (pSCC) and glioblastoma (GB) are rare malignant tumors that develop especially in the elderly. The aim of our paper is to present two patients diagnosed and treated for a cerebral GB developed after a prior pSCC and to discuss the possible mechanism of their association. PATIENTS, MATERIALS, AND METHODS: The medical records of 632 patients admitted for a GB in the Department of Neurosurgery, "Prof. Dr. Nicolae Oblu" Emergency Clinical Hospital, Iasi, Romania, between April 2010 and April 2018, were retrospectively searched for those having a prior histological proven cancer. The review found only two patients (0.31% of all cases with GB) and their demographics, clinical presentation, medical history, treatment and pathological diagnosis were reviewed and discussed. RESULTS: Both patients were 65-year-old on their admission in the Department of Neurosurgery. Their prior penile tumors were both located at the penis glans. In both cases, the histopathological exam revealed a penile keratinized squamous cell carcinoma stage T1aN0M0 at the moment of their first urological diagnosis. At the time of the neurosurgical evaluation, brain radiological investigations demonstrated right frontal cystic neoformation in the first case, and a right frontal-parietal solid, expansive lesion for the second patient. The patients underwent subtotal surgical excision of their brain masses. The histopathological exam revealed in both cases a World Health Organization (WHO) grade IV GB. CONCLUSIONS: This is the first clinical report of a new association between pSCC and subsequent development of GB in a series of two patients. Both our patients developed a prior pSCC without any lymph node and distant metastasis at their first diagnosis and this situation reinforces the idea that this type of cancer has a good prognosis and that the patient can develop a second cancer during his post-penectomy life, probably due to a genetic predisposition, post-therapeutic effects, life style factors (smoke effects), sporadic association, or due to the common embryological origin of the nervous and skin tissues.

[Histological studies in cataract--effect of USIOL IOL's in posterior capsule of rabbits]. / Observatii histologice în cataracta; efectul implantelor USIOL asupra capsulei posterioare cristaliniene la iepuri.

UNLABELLED: Cataract represents a degenerative process of lens structures with multifactor causes. STUDY OBJECTIVES: are to present histopathological modificatios at different types of cataract and to demonstrate the USIOL lens effects at rabbit posterior capsule, after extracapsular surgery. MATERIAL AND METHOD: It was performed a comparative histological study at different types of cataract. It was implanted PMMA and acrylic USIOL lens at 2 rabbits. Follow-up was for 3 months and after ECCE it was performed histopathological examination of posterior lens capsules. RESULTS AND CONCLUSIONS: There are few histological observations which can suggests the cataract cause. USIOL implants are well tolerated and the posterior lens capsule modifications after IOL implantation are not important.